Identification and phenotypic characterization of patients with LADA in a population of southeast Mexico
Abstract Latent autoimmune diabetes in adults (LADA) has clinical and metabolic features of type 1 and type 2 diabetes. LADA does not have specific features for its diagnosis apart from autoantibody detection; however, these tests are not affordable in clinical settings. In this cross-sectional stud...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34171-2 |
| _version_ | 1797836490792763392 |
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| author | Germán Alberto Nolasco-Rosales Dania Ramírez-González Ester Rodríguez-Sánchez Ángela Ávila-Fernandez Guillermo Efrén Villar-Juarez Thelma Beatriz González-Castro Carlos Alfonso Tovilla-Zárate Crystell Guadalupe Guzmán-Priego Alma Delia Genis-Mendoza Jorge Luis Ble-Castillo Alejandro Marín-Medina Isela Esther Juárez-Rojop |
| author_facet | Germán Alberto Nolasco-Rosales Dania Ramírez-González Ester Rodríguez-Sánchez Ángela Ávila-Fernandez Guillermo Efrén Villar-Juarez Thelma Beatriz González-Castro Carlos Alfonso Tovilla-Zárate Crystell Guadalupe Guzmán-Priego Alma Delia Genis-Mendoza Jorge Luis Ble-Castillo Alejandro Marín-Medina Isela Esther Juárez-Rojop |
| author_sort | Germán Alberto Nolasco-Rosales |
| collection | DOAJ |
| description | Abstract Latent autoimmune diabetes in adults (LADA) has clinical and metabolic features of type 1 and type 2 diabetes. LADA does not have specific features for its diagnosis apart from autoantibody detection; however, these tests are not affordable in clinical settings. In this cross-sectional study, we analyzed clinical criteria, metabolic control, pharmacological treatment, and diabetic complications in two groups of patients with diabetes -LADA and T2D- in order to identify specific characteristic of these clinical entities. Finally, we evaluated if the estimated glucose disposal rate (eGDR) and age at diagnosis of diabetes could be used as a diagnostic criterion for LADA. Demographic, biochemical, clinical and treatment were measured in 377 individuals with diabetes. The diagnostics of LADA were determined using Glutamic acid decarboxylase autoantibodies levels. Chi-square test or t-Student test were used to establish differences between groups. To identify factors associated with LADA, a logistic regression analysis was used. Finally, a ROC curve was plotted to assess the possible variables as diagnostic criteria for LADA. The 377 patients with diabetes were separated into 59 patients with LADA and 318 patients with T2D. Patients with LADA showed lower fasting glucose values, fewer diabetic complications, younger age at diagnosis of diabetes, higher insulin use, and higher eGDR in comparison to patients with T2D. Both groups had a mean BMI classified as overweight. The ROC evaluated the sensitivity and specificity, this analysis indicated that an age younger than 40.5 years and an eGDR value higher than 9.75 mg/kg/min correlated better with LADA. These parameters could be useful to identify patients suspected to have LADA at the first level of medical care in the population of southeastern Mexico and refer them to a second level of care. |
| first_indexed | 2024-04-09T15:10:48Z |
| format | Article |
| id | doaj.art-8bed265093ec4d7bb1b29be00caff679 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T15:10:48Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8bed265093ec4d7bb1b29be00caff6792023-04-30T11:14:50ZengNature PortfolioScientific Reports2045-23222023-04-011311910.1038/s41598-023-34171-2Identification and phenotypic characterization of patients with LADA in a population of southeast MexicoGermán Alberto Nolasco-Rosales0Dania Ramírez-González1Ester Rodríguez-Sánchez2Ángela Ávila-Fernandez3Guillermo Efrén Villar-Juarez4Thelma Beatriz González-Castro5Carlos Alfonso Tovilla-Zárate6Crystell Guadalupe Guzmán-Priego7Alma Delia Genis-Mendoza8Jorge Luis Ble-Castillo9Alejandro Marín-Medina10Isela Esther Juárez-Rojop11División Académica de Ciencias de la Salud, Universidad Juarez Autónoma de TabascoDivisión Académica de Ciencias de la Salud, Universidad Juarez Autónoma de TabascoHospital Regional de Alta Especialidad “Gustavo A. Rovirosa Pérez”División Académica de Ciencias de la Salud, Universidad Juarez Autónoma de TabascoEscuela de Medicina, Universidad Anáhuac QuerétaroDivisión Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juarez Autónoma de TabascoDivisión Académica Multidisciplinaria de Comalcalco, Universidad Juarez Autónoma de TabascoDivisión Académica de Ciencias de la Salud, Universidad Juarez Autónoma de TabascoDepartamento de Genética Psiquiátrica, Instituto Nacional de Medicina GenómicaDivisión Académica de Ciencias de la Salud, Universidad Juarez Autónoma de TabascoUniversidad de Guadalajara, CUCSDivisión Académica de Ciencias de la Salud, Universidad Juarez Autónoma de TabascoAbstract Latent autoimmune diabetes in adults (LADA) has clinical and metabolic features of type 1 and type 2 diabetes. LADA does not have specific features for its diagnosis apart from autoantibody detection; however, these tests are not affordable in clinical settings. In this cross-sectional study, we analyzed clinical criteria, metabolic control, pharmacological treatment, and diabetic complications in two groups of patients with diabetes -LADA and T2D- in order to identify specific characteristic of these clinical entities. Finally, we evaluated if the estimated glucose disposal rate (eGDR) and age at diagnosis of diabetes could be used as a diagnostic criterion for LADA. Demographic, biochemical, clinical and treatment were measured in 377 individuals with diabetes. The diagnostics of LADA were determined using Glutamic acid decarboxylase autoantibodies levels. Chi-square test or t-Student test were used to establish differences between groups. To identify factors associated with LADA, a logistic regression analysis was used. Finally, a ROC curve was plotted to assess the possible variables as diagnostic criteria for LADA. The 377 patients with diabetes were separated into 59 patients with LADA and 318 patients with T2D. Patients with LADA showed lower fasting glucose values, fewer diabetic complications, younger age at diagnosis of diabetes, higher insulin use, and higher eGDR in comparison to patients with T2D. Both groups had a mean BMI classified as overweight. The ROC evaluated the sensitivity and specificity, this analysis indicated that an age younger than 40.5 years and an eGDR value higher than 9.75 mg/kg/min correlated better with LADA. These parameters could be useful to identify patients suspected to have LADA at the first level of medical care in the population of southeastern Mexico and refer them to a second level of care.https://doi.org/10.1038/s41598-023-34171-2 |
| spellingShingle | Germán Alberto Nolasco-Rosales Dania Ramírez-González Ester Rodríguez-Sánchez Ángela Ávila-Fernandez Guillermo Efrén Villar-Juarez Thelma Beatriz González-Castro Carlos Alfonso Tovilla-Zárate Crystell Guadalupe Guzmán-Priego Alma Delia Genis-Mendoza Jorge Luis Ble-Castillo Alejandro Marín-Medina Isela Esther Juárez-Rojop Identification and phenotypic characterization of patients with LADA in a population of southeast Mexico Scientific Reports |
| title | Identification and phenotypic characterization of patients with LADA in a population of southeast Mexico |
| title_full | Identification and phenotypic characterization of patients with LADA in a population of southeast Mexico |
| title_fullStr | Identification and phenotypic characterization of patients with LADA in a population of southeast Mexico |
| title_full_unstemmed | Identification and phenotypic characterization of patients with LADA in a population of southeast Mexico |
| title_short | Identification and phenotypic characterization of patients with LADA in a population of southeast Mexico |
| title_sort | identification and phenotypic characterization of patients with lada in a population of southeast mexico |
| url | https://doi.org/10.1038/s41598-023-34171-2 |
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