Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective study
Background: There has been a rapid increase in the number of human adenovirus type 7 (HAdV-7) and invasive pulmonary fungal infections (IPFIs) co-infection. Methods: In this study, we included patients with confirmed HAdV-7 infection during the period from 2018 to 2019 to explore clinical characteri...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957222000602 |
| _version_ | 1818113426846646272 |
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| author | P.Q. Huang H. Du H.B. Chen Y. Li H.W. Chen X.L. Lei M.R. Zhang X.X. Lu |
| author_facet | P.Q. Huang H. Du H.B. Chen Y. Li H.W. Chen X.L. Lei M.R. Zhang X.X. Lu |
| author_sort | P.Q. Huang |
| collection | DOAJ |
| description | Background: There has been a rapid increase in the number of human adenovirus type 7 (HAdV-7) and invasive pulmonary fungal infections (IPFIs) co-infection. Methods: In this study, we included patients with confirmed HAdV-7 infection during the period from 2018 to 2019 to explore clinical characteristics of severe HAdV-7 pneumonia combined with IPFIs. Results: Among the 143 patients, 35 cases were co-infected with IPFIs. Others were assigned to the control group (n Z 108). Patients wereprone to be complicated with respiratory failure, heart failure and hemophagocytic syndromein IPFIs group. Thirty-one species of fungi were detected in the IPFIs group, among whichAspergillus was the most common species. Compared to control group, patients had lowerlevels of WBC, CD3þ T lymphocyte counts and CD19þ B lymphocyte counts in IPFIs group. Conclusion: Aspergillus is the most common species in IPFIs combined with severe HAdV-7 pneumonia. For children with severe HAdV-7 pneumonia who are younger, have a long course of disease, and have been admitted to the ICU, we should predict the occurrence of IPFIs when there is multi-system dysfunction and the reduction of CD3+ T lymphocyte counts and CD19+ B lymphocyte counts in course of their disease. |
| first_indexed | 2024-12-11T03:34:39Z |
| format | Article |
| id | doaj.art-8beda783b1234658bc1d52cef5ebfe5d |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-11T03:34:39Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-8beda783b1234658bc1d52cef5ebfe5d2022-12-22T01:22:17ZengElsevierPediatrics and Neonatology1875-95722022-07-01634388393Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective studyP.Q. Huang0H. Du1H.B. Chen2Y. Li3H.W. Chen4X.L. Lei5M.R. Zhang6X.X. Lu7Department of Electrocardiogram, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, ChinaDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, ChinaDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, ChinaDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, ChinaDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, ChinaDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, ChinaDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, ChinaDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, China; Corresponding author. Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hongkong Road 100, Wuhan, 430015, Hubei, China.Background: There has been a rapid increase in the number of human adenovirus type 7 (HAdV-7) and invasive pulmonary fungal infections (IPFIs) co-infection. Methods: In this study, we included patients with confirmed HAdV-7 infection during the period from 2018 to 2019 to explore clinical characteristics of severe HAdV-7 pneumonia combined with IPFIs. Results: Among the 143 patients, 35 cases were co-infected with IPFIs. Others were assigned to the control group (n Z 108). Patients wereprone to be complicated with respiratory failure, heart failure and hemophagocytic syndromein IPFIs group. Thirty-one species of fungi were detected in the IPFIs group, among whichAspergillus was the most common species. Compared to control group, patients had lowerlevels of WBC, CD3þ T lymphocyte counts and CD19þ B lymphocyte counts in IPFIs group. Conclusion: Aspergillus is the most common species in IPFIs combined with severe HAdV-7 pneumonia. For children with severe HAdV-7 pneumonia who are younger, have a long course of disease, and have been admitted to the ICU, we should predict the occurrence of IPFIs when there is multi-system dysfunction and the reduction of CD3+ T lymphocyte counts and CD19+ B lymphocyte counts in course of their disease.http://www.sciencedirect.com/science/article/pii/S1875957222000602childrenclinical manifestationhuman adenovirus type 7invasive pulmonary fungal infections |
| spellingShingle | P.Q. Huang H. Du H.B. Chen Y. Li H.W. Chen X.L. Lei M.R. Zhang X.X. Lu Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective study Pediatrics and Neonatology children clinical manifestation human adenovirus type 7 invasive pulmonary fungal infections |
| title | Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective study |
| title_full | Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective study |
| title_fullStr | Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective study |
| title_full_unstemmed | Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective study |
| title_short | Invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia: A retrospective study |
| title_sort | invasive pulmonary fungal infections in children with severe human adenovirus type 7 pneumonia a retrospective study |
| topic | children clinical manifestation human adenovirus type 7 invasive pulmonary fungal infections |
| url | http://www.sciencedirect.com/science/article/pii/S1875957222000602 |
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