Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries
PurposeDescribe real-life practice and outcomes in the management of post-stroke upper limb spasticity with botulinum toxin A (BoNT-A) in Asian settings.MethodsSubgroup analysis of a prospective, observational study (NCT01020500) of adult patients (≥18 years) with post-stroke upper limb spasticity p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1335365/full |
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| author | Raymond L. Rosales Raymond L. Rosales Nicholas V. C. Chia Witsanu Kumthornthip Khean Jin Goh Choon Soon Mak Keng He Kong Yee Sien Ng Li Wei Chou M. Jeanne Flordelis Thuy Do Pascal Maisonobe Leonard S. W. Li Areerat Suputtitada Areerat Suputtitada |
| author_facet | Raymond L. Rosales Raymond L. Rosales Nicholas V. C. Chia Witsanu Kumthornthip Khean Jin Goh Choon Soon Mak Keng He Kong Yee Sien Ng Li Wei Chou M. Jeanne Flordelis Thuy Do Pascal Maisonobe Leonard S. W. Li Areerat Suputtitada Areerat Suputtitada |
| author_sort | Raymond L. Rosales |
| collection | DOAJ |
| description | PurposeDescribe real-life practice and outcomes in the management of post-stroke upper limb spasticity with botulinum toxin A (BoNT-A) in Asian settings.MethodsSubgroup analysis of a prospective, observational study (NCT01020500) of adult patients (≥18 years) with post-stroke upper limb spasticity presenting for routine spasticity management, including treatment with BoNT-A. The primary outcome was goal attainment as assessed using goal-attainment scaling (GAS). Patients baseline clinical characteristics and BoNT-A injection parameters are also described.ResultsOverall, 51 patients from Asia were enrolled. Rates of comorbid cognitive and emotional problems were relatively low. Patients tended to have more severe distal limb spasticity and to prioritize active over passive function goals. Most (94.1%) patients in the subgroup were treated with abobotulinumtoxinA. For these patients, the median total dose was 500 units, and the most frequently injected muscles were the biceps brachii (83.3%), flexor carpi radialis (72.9%), and flexor digitorum profundus (66.7%). Overall, 74.5% achieved their primary goal and the mean GAS T score after one treatment cycle was 56.0 ± 13.0, with a change from baseline of 20.9 ± 14.3 (p < 0.001). The majority (96.1%) of Asian patients were rated as having improved.ConclusionIn the Asian treatment setting, BoNT-A demonstrated a clinically significant effect on goal attainment for the real-life management of upper limb spasticity following stroke. |
| first_indexed | 2024-04-24T12:02:04Z |
| format | Article |
| id | doaj.art-8bee9e78d51842ff96f338a8be05ea42 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-24T12:02:04Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-8bee9e78d51842ff96f338a8be05ea422024-04-08T15:02:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-04-011510.3389/fneur.2024.13353651335365Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countriesRaymond L. Rosales0Raymond L. Rosales1Nicholas V. C. Chia2Witsanu Kumthornthip3Khean Jin Goh4Choon Soon Mak5Keng He Kong6Yee Sien Ng7Li Wei Chou8M. Jeanne Flordelis9Thuy Do10Pascal Maisonobe11Leonard S. W. Li12Areerat Suputtitada13Areerat Suputtitada14Department of Neurology and Psychiatry, University of Santo Tomas, Manila, PhilippinesDepartment of Neuroscience and Brain Health, Center for Neurodiagnostic and Therapeutic Service, Metropolitan Medical Center, Manila, PhilippinesIpsen, Singapore, SingaporeFaculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDivision of Neurology, University of Malaya Medical Centre, Kuala Lumpur, MalaysiaHospital Kuala Lumpur, Kuala Lumpur, MalaysiaTan Tock Seng Hospital, Singapore, SingaporeSingapore General Hospital, Singapore, SingaporeChina Medical University Hospital, Taichung, Taiwan0Perpetual Succor Hospital, Cebu City, Philippines1Ipsen, Ho Chi Minh City, Vietnam2Ipsen, Boulogne-Billancourt, France3Tung Wah Hospital, Hong Kong, Hong Kong SAR, China4Department of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand5King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, ThailandPurposeDescribe real-life practice and outcomes in the management of post-stroke upper limb spasticity with botulinum toxin A (BoNT-A) in Asian settings.MethodsSubgroup analysis of a prospective, observational study (NCT01020500) of adult patients (≥18 years) with post-stroke upper limb spasticity presenting for routine spasticity management, including treatment with BoNT-A. The primary outcome was goal attainment as assessed using goal-attainment scaling (GAS). Patients baseline clinical characteristics and BoNT-A injection parameters are also described.ResultsOverall, 51 patients from Asia were enrolled. Rates of comorbid cognitive and emotional problems were relatively low. Patients tended to have more severe distal limb spasticity and to prioritize active over passive function goals. Most (94.1%) patients in the subgroup were treated with abobotulinumtoxinA. For these patients, the median total dose was 500 units, and the most frequently injected muscles were the biceps brachii (83.3%), flexor carpi radialis (72.9%), and flexor digitorum profundus (66.7%). Overall, 74.5% achieved their primary goal and the mean GAS T score after one treatment cycle was 56.0 ± 13.0, with a change from baseline of 20.9 ± 14.3 (p < 0.001). The majority (96.1%) of Asian patients were rated as having improved.ConclusionIn the Asian treatment setting, BoNT-A demonstrated a clinically significant effect on goal attainment for the real-life management of upper limb spasticity following stroke.https://www.frontiersin.org/articles/10.3389/fneur.2024.1335365/fullAsiabotulinum toxinpost-strokespasticityupper limb |
| spellingShingle | Raymond L. Rosales Raymond L. Rosales Nicholas V. C. Chia Witsanu Kumthornthip Khean Jin Goh Choon Soon Mak Keng He Kong Yee Sien Ng Li Wei Chou M. Jeanne Flordelis Thuy Do Pascal Maisonobe Leonard S. W. Li Areerat Suputtitada Areerat Suputtitada Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries Frontiers in Neurology Asia botulinum toxin post-stroke spasticity upper limb |
| title | Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries |
| title_full | Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries |
| title_fullStr | Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries |
| title_full_unstemmed | Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries |
| title_short | Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries |
| title_sort | botulinum toxin a injection for post stroke upper limb spasticity and rehabilitation practices from centers across asian countries |
| topic | Asia botulinum toxin post-stroke spasticity upper limb |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1335365/full |
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