Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors
Abstract Background The proportion of mosquito blood-meals that are of human origin, referred to as the ‘human blood index’ or HBI, is a key determinant of malaria transmission. Methods A systematic review was conducted followed by meta-regression of the HBI for the major African malaria vectors. Re...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12936-018-2632-7 |
| _version_ | 1817987929428983808 |
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| author | James Orsborne Luis Furuya-Kanamori Claire L. Jeffries Mojca Kristan Abdul Rahim Mohammed Yaw A. Afrane Kathleen O’Reilly Eduardo Massad Chris Drakeley Thomas Walker Laith Yakob |
| author_facet | James Orsborne Luis Furuya-Kanamori Claire L. Jeffries Mojca Kristan Abdul Rahim Mohammed Yaw A. Afrane Kathleen O’Reilly Eduardo Massad Chris Drakeley Thomas Walker Laith Yakob |
| author_sort | James Orsborne |
| collection | DOAJ |
| description | Abstract Background The proportion of mosquito blood-meals that are of human origin, referred to as the ‘human blood index’ or HBI, is a key determinant of malaria transmission. Methods A systematic review was conducted followed by meta-regression of the HBI for the major African malaria vectors. Results Evidence is presented for higher HBI among Anopheles gambiae (M/S forms and Anopheles coluzzii/An. gambiae sensu stricto are not distinguished for most studies and, therefore, combined) as well as Anopheles funestus when compared with Anopheles arabiensis (prevalence odds ratio adjusted for collection location [i.e. indoor or outdoor]: 1.62; 95% CI 1.09–2.42; 1.84; 95% CI 1.35–2.52, respectively). This finding is in keeping with the entomological literature which describes An. arabiensis to be more zoophagic than the other major African vectors. However, analysis also revealed that HBI was more associated with location of mosquito captures (R2 = 0.29) than with mosquito (sibling) species (R2 = 0.11). Conclusions These findings call into question the appropriateness of current methods of assessing host preferences among disease vectors and have important implications for strategizing vector control. |
| first_indexed | 2024-04-14T00:28:34Z |
| format | Article |
| id | doaj.art-8befbccbe4f8414899db4ba273810908 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-14T00:28:34Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-8befbccbe4f8414899db4ba2738109082022-12-22T02:22:38ZengBMCMalaria Journal1475-28752018-12-011711810.1186/s12936-018-2632-7Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectorsJames Orsborne0Luis Furuya-Kanamori1Claire L. Jeffries2Mojca Kristan3Abdul Rahim Mohammed4Yaw A. Afrane5Kathleen O’Reilly6Eduardo Massad7Chris Drakeley8Thomas Walker9Laith Yakob10Department of Disease Control, London School of Hygiene & Tropical MedicineDepartment of Population Medicine, College of Medicine, Qatar UniversityDepartment of Disease Control, London School of Hygiene & Tropical MedicineDepartment of Disease Control, London School of Hygiene & Tropical MedicineDepartment of Medical Microbiology, College of Health Sciences, University of Ghana, Korle BuDepartment of Medical Microbiology, College of Health Sciences, University of Ghana, Korle BuDepartment of Disease Control, London School of Hygiene & Tropical MedicineSchool of Applied Mathematics, Fundacao Getulio VargasDepartment of Immunology & Infection, London School of Hygiene & Tropical MedicineDepartment of Disease Control, London School of Hygiene & Tropical MedicineDepartment of Disease Control, London School of Hygiene & Tropical MedicineAbstract Background The proportion of mosquito blood-meals that are of human origin, referred to as the ‘human blood index’ or HBI, is a key determinant of malaria transmission. Methods A systematic review was conducted followed by meta-regression of the HBI for the major African malaria vectors. Results Evidence is presented for higher HBI among Anopheles gambiae (M/S forms and Anopheles coluzzii/An. gambiae sensu stricto are not distinguished for most studies and, therefore, combined) as well as Anopheles funestus when compared with Anopheles arabiensis (prevalence odds ratio adjusted for collection location [i.e. indoor or outdoor]: 1.62; 95% CI 1.09–2.42; 1.84; 95% CI 1.35–2.52, respectively). This finding is in keeping with the entomological literature which describes An. arabiensis to be more zoophagic than the other major African vectors. However, analysis also revealed that HBI was more associated with location of mosquito captures (R2 = 0.29) than with mosquito (sibling) species (R2 = 0.11). Conclusions These findings call into question the appropriateness of current methods of assessing host preferences among disease vectors and have important implications for strategizing vector control.http://link.springer.com/article/10.1186/s12936-018-2632-7Blood meal analysisHost preferenceMosquitoBiting preferenceBlood index |
| spellingShingle | James Orsborne Luis Furuya-Kanamori Claire L. Jeffries Mojca Kristan Abdul Rahim Mohammed Yaw A. Afrane Kathleen O’Reilly Eduardo Massad Chris Drakeley Thomas Walker Laith Yakob Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors Malaria Journal Blood meal analysis Host preference Mosquito Biting preference Blood index |
| title | Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors |
| title_full | Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors |
| title_fullStr | Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors |
| title_full_unstemmed | Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors |
| title_short | Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors |
| title_sort | using the human blood index to investigate host biting plasticity a systematic review and meta regression of the three major african malaria vectors |
| topic | Blood meal analysis Host preference Mosquito Biting preference Blood index |
| url | http://link.springer.com/article/10.1186/s12936-018-2632-7 |
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