High-Frequency Ultrasound to Assess Activity in Connective Tissue Panniculitis
Determining disease activity from clinical signs in patients with connective tissue panniculitis (CTP) is often challenging but is essential for therapeutic decision making, which largely relies on immunosuppressant treatment. High-frequency ultrasound (HFUS) may be useful in supporting such decisio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/19/4516 |
| _version_ | 1797516138872045568 |
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| author | Priscila Giavedoni Sebastian Podlipnik Irene Fuertes de Vega Pilar Iranzo José Manuel Mascaró |
| author_facet | Priscila Giavedoni Sebastian Podlipnik Irene Fuertes de Vega Pilar Iranzo José Manuel Mascaró |
| author_sort | Priscila Giavedoni |
| collection | DOAJ |
| description | Determining disease activity from clinical signs in patients with connective tissue panniculitis (CTP) is often challenging but is essential for therapeutic decision making, which largely relies on immunosuppressant treatment. High-frequency ultrasound (HFUS) may be useful in supporting such decisions by accurately determining CTP activity. This study aimed to investigate the accuracy of HFUS in identifying signs of CTP activity or inactivity and assess its usefulness in therapeutic decision making. A prospective cohort study of consecutive patients with biopsy-proven CTP receiving HFUS was conducted in a tertiary university hospital (2016–2020). HFUS was performed at inclusion and at each 3- or 6-month follow-up visit, depending on disease activity. Twenty-three patients with CTP were included, and 134 HFUSs were performed. In 59.7% (80) of the evaluations, the clinical presentation did not show whether CTP was active or not. In these cases, HFUS showed activity in 38.7% (31) and inactivity in 61.3% (49). In 71.25% (57) of the visits, HFUS was the determinant for therapeutic decisions. Further follow-up showed consistent clinical and HFUS responses in all unclear cases after treatment modification. HFUS appears to be a useful adjunct to the clinical examination for CTP to assess activity and make therapeutic decisions. |
| first_indexed | 2024-03-10T06:58:05Z |
| format | Article |
| id | doaj.art-8bf0ee1499dc4318aeb7d663bbb2435a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T06:58:05Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8bf0ee1499dc4318aeb7d663bbb2435a2023-11-22T16:20:35ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011019451610.3390/jcm10194516High-Frequency Ultrasound to Assess Activity in Connective Tissue PanniculitisPriscila Giavedoni0Sebastian Podlipnik1Irene Fuertes de Vega2Pilar Iranzo3José Manuel Mascaró4Department of Dermatology, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Dermatology, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Dermatology, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Dermatology, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Dermatology, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDetermining disease activity from clinical signs in patients with connective tissue panniculitis (CTP) is often challenging but is essential for therapeutic decision making, which largely relies on immunosuppressant treatment. High-frequency ultrasound (HFUS) may be useful in supporting such decisions by accurately determining CTP activity. This study aimed to investigate the accuracy of HFUS in identifying signs of CTP activity or inactivity and assess its usefulness in therapeutic decision making. A prospective cohort study of consecutive patients with biopsy-proven CTP receiving HFUS was conducted in a tertiary university hospital (2016–2020). HFUS was performed at inclusion and at each 3- or 6-month follow-up visit, depending on disease activity. Twenty-three patients with CTP were included, and 134 HFUSs were performed. In 59.7% (80) of the evaluations, the clinical presentation did not show whether CTP was active or not. In these cases, HFUS showed activity in 38.7% (31) and inactivity in 61.3% (49). In 71.25% (57) of the visits, HFUS was the determinant for therapeutic decisions. Further follow-up showed consistent clinical and HFUS responses in all unclear cases after treatment modification. HFUS appears to be a useful adjunct to the clinical examination for CTP to assess activity and make therapeutic decisions.https://www.mdpi.com/2077-0383/10/19/4516high-frequency ultrasoundconnective tissue panniculitiscutaneous lupus erythematosusdermatomyositisdiagnosisinflammation |
| spellingShingle | Priscila Giavedoni Sebastian Podlipnik Irene Fuertes de Vega Pilar Iranzo José Manuel Mascaró High-Frequency Ultrasound to Assess Activity in Connective Tissue Panniculitis Journal of Clinical Medicine high-frequency ultrasound connective tissue panniculitis cutaneous lupus erythematosus dermatomyositis diagnosis inflammation |
| title | High-Frequency Ultrasound to Assess Activity in Connective Tissue Panniculitis |
| title_full | High-Frequency Ultrasound to Assess Activity in Connective Tissue Panniculitis |
| title_fullStr | High-Frequency Ultrasound to Assess Activity in Connective Tissue Panniculitis |
| title_full_unstemmed | High-Frequency Ultrasound to Assess Activity in Connective Tissue Panniculitis |
| title_short | High-Frequency Ultrasound to Assess Activity in Connective Tissue Panniculitis |
| title_sort | high frequency ultrasound to assess activity in connective tissue panniculitis |
| topic | high-frequency ultrasound connective tissue panniculitis cutaneous lupus erythematosus dermatomyositis diagnosis inflammation |
| url | https://www.mdpi.com/2077-0383/10/19/4516 |
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