Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces
A microchannel device was designed and utilized to separate Michigan Cancer Foundation-7 cells from white blood cells using both wall-induced lift and di-electrophoresis forces. Using COMSOL Multiphysics simulator, the label-free separation process is performed based on the radius size of the partic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Islamic Azad University-Isfahan (Khorasgan) Branch
2022-09-01
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| Series: | International Journal of Advanced Design and Manufacturing Technology |
| Subjects: | |
| Online Access: | https://admt.isfahan.iau.ir/article_695354_cbe2005457dbd3a90c2d3dd05e85bed4.pdf |
| _version_ | 1797657471500681216 |
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| author | Alireza Alaghemand Ali Fattah |
| author_facet | Alireza Alaghemand Ali Fattah |
| author_sort | Alireza Alaghemand |
| collection | DOAJ |
| description | A microchannel device was designed and utilized to separate Michigan Cancer Foundation-7 cells from white blood cells using both wall-induced lift and di-electrophoresis forces. Using COMSOL Multiphysics simulator, the label-free separation process is performed based on the radius size of the particles. The best performance of the structure is obtained with the efficiency of 100% and 99% for cancer and white blood cells separation processes, respectively. For the proposed microfluidic structure, in addition to the highest available efficiency and high separation speed of 12 um/s, the low DC voltage of 6 V is applied, which causes negligible damage to the blood cells. |
| first_indexed | 2024-03-11T17:44:58Z |
| format | Article |
| id | doaj.art-8bf20c01e6d84f5cb555fcf96637e28e |
| institution | Directory Open Access Journal |
| issn | 2252-0406 2383-4447 |
| language | English |
| last_indexed | 2024-03-11T17:44:58Z |
| publishDate | 2022-09-01 |
| publisher | Islamic Azad University-Isfahan (Khorasgan) Branch |
| record_format | Article |
| series | International Journal of Advanced Design and Manufacturing Technology |
| spelling | doaj.art-8bf20c01e6d84f5cb555fcf96637e28e2023-10-18T08:36:00ZengIslamic Azad University-Isfahan (Khorasgan) BranchInternational Journal of Advanced Design and Manufacturing Technology2252-04062383-44472022-09-011539910710.30486/admt.2022.1957227.1347695354Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis ForcesAlireza Alaghemand0Ali Fattah1Electrical Engineering Department, Shahrood University of Technology, Shahrood, IranElectrical Engineering Department, Shahrood University of Technology, Shahrood, IranA microchannel device was designed and utilized to separate Michigan Cancer Foundation-7 cells from white blood cells using both wall-induced lift and di-electrophoresis forces. Using COMSOL Multiphysics simulator, the label-free separation process is performed based on the radius size of the particles. The best performance of the structure is obtained with the efficiency of 100% and 99% for cancer and white blood cells separation processes, respectively. For the proposed microfluidic structure, in addition to the highest available efficiency and high separation speed of 12 um/s, the low DC voltage of 6 V is applied, which causes negligible damage to the blood cells.https://admt.isfahan.iau.ir/article_695354_cbe2005457dbd3a90c2d3dd05e85bed4.pdfcancer cellscomsoldielectrophoresismicrofluidicsseparation |
| spellingShingle | Alireza Alaghemand Ali Fattah Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces International Journal of Advanced Design and Manufacturing Technology cancer cells comsol dielectrophoresis microfluidics separation |
| title | Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces |
| title_full | Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces |
| title_fullStr | Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces |
| title_full_unstemmed | Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces |
| title_short | Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces |
| title_sort | label free perfect separation of michigan cancer foundation 7 cells from white blood cells using both wall induced lift and dielectrophoresis forces |
| topic | cancer cells comsol dielectrophoresis microfluidics separation |
| url | https://admt.isfahan.iau.ir/article_695354_cbe2005457dbd3a90c2d3dd05e85bed4.pdf |
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