Enhanced Fungicidal Efficacy by Co-Delivery of Azoxystrobin and Diniconazole with Cauliflower-Like Metal–Organic Frameworks NH<sub>2</sub>-Al-MIL-101
Long-term use of a single fungicide increases the resistance risk and causes adverse effects on natural ecosystems. Controlled release formulations of dual fungicides with different modes of action can afford a new dimension for addressing the current issues. Based on adjustable aperture and superhi...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/19/10412 |
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| author | Huiping Chen Yongpan Shan Lidong Cao Pengyue Zhao Chong Cao Fengmin Li Qiliang Huang |
| author_facet | Huiping Chen Yongpan Shan Lidong Cao Pengyue Zhao Chong Cao Fengmin Li Qiliang Huang |
| author_sort | Huiping Chen |
| collection | DOAJ |
| description | Long-term use of a single fungicide increases the resistance risk and causes adverse effects on natural ecosystems. Controlled release formulations of dual fungicides with different modes of action can afford a new dimension for addressing the current issues. Based on adjustable aperture and superhigh surface area, metal–organic frameworks (MOFs) are ideal candidates as pesticide release carriers. This study used Al<sup>3+</sup> as the metal node and 2-aminoterephthalic acid as the organic chain to prepare aluminum-based metal–organic framework material (NH<sub>2</sub>-Al-MIL-101) with “cauliflower-like” structure and high surface area of 2359.0 m<sup>2</sup>/g. Fungicides of azoxystrobin (AZOX) and diniconazole (Dini) were simultaneously encapsulated into NH<sub>2</sub>-Al-MIL-101 with the loading content of 6.71% and 29.72%, respectively. Dual fungicide delivery system of AZOX@Dini@NH<sub>2</sub>-Al-MIL-101 demonstrated sustained and pH responsive release profiles. When the maximum cumulative release rate of AZOX and Dini both reached about 90%, the release time was 46 and 136 h, respectively. Furthermore, EC<sub>50</sub> values as well as the percentage of inhibition revealed that AZOX@Dini@NH<sub>2</sub>-Al-MIL-101 had enhanced germicidal efficacy against rice sheath blight (<i>Rhizoctonia solani</i>), evidenced by the synergistic ratio of 1.83. The present study demonstrates a potential application prospect in sustainable plant protection through co-delivery fungicides with MOFs as a platform. |
| first_indexed | 2024-03-10T07:00:00Z |
| format | Article |
| id | doaj.art-8bf31994bee34c479ba9c8efe9c70f61 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:00:00Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8bf31994bee34c479ba9c8efe9c70f612023-11-22T16:09:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122191041210.3390/ijms221910412Enhanced Fungicidal Efficacy by Co-Delivery of Azoxystrobin and Diniconazole with Cauliflower-Like Metal–Organic Frameworks NH<sub>2</sub>-Al-MIL-101Huiping Chen0Yongpan Shan1Lidong Cao2Pengyue Zhao3Chong Cao4Fengmin Li5Qiliang Huang6Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaKey Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaKey Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaKey Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaKey Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaKey Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaKey Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaLong-term use of a single fungicide increases the resistance risk and causes adverse effects on natural ecosystems. Controlled release formulations of dual fungicides with different modes of action can afford a new dimension for addressing the current issues. Based on adjustable aperture and superhigh surface area, metal–organic frameworks (MOFs) are ideal candidates as pesticide release carriers. This study used Al<sup>3+</sup> as the metal node and 2-aminoterephthalic acid as the organic chain to prepare aluminum-based metal–organic framework material (NH<sub>2</sub>-Al-MIL-101) with “cauliflower-like” structure and high surface area of 2359.0 m<sup>2</sup>/g. Fungicides of azoxystrobin (AZOX) and diniconazole (Dini) were simultaneously encapsulated into NH<sub>2</sub>-Al-MIL-101 with the loading content of 6.71% and 29.72%, respectively. Dual fungicide delivery system of AZOX@Dini@NH<sub>2</sub>-Al-MIL-101 demonstrated sustained and pH responsive release profiles. When the maximum cumulative release rate of AZOX and Dini both reached about 90%, the release time was 46 and 136 h, respectively. Furthermore, EC<sub>50</sub> values as well as the percentage of inhibition revealed that AZOX@Dini@NH<sub>2</sub>-Al-MIL-101 had enhanced germicidal efficacy against rice sheath blight (<i>Rhizoctonia solani</i>), evidenced by the synergistic ratio of 1.83. The present study demonstrates a potential application prospect in sustainable plant protection through co-delivery fungicides with MOFs as a platform.https://www.mdpi.com/1422-0067/22/19/10412NH<sub>2</sub>-Al-MIL-101controlled releasedual encapsulationsynergistic effectrice sheath blight |
| spellingShingle | Huiping Chen Yongpan Shan Lidong Cao Pengyue Zhao Chong Cao Fengmin Li Qiliang Huang Enhanced Fungicidal Efficacy by Co-Delivery of Azoxystrobin and Diniconazole with Cauliflower-Like Metal–Organic Frameworks NH<sub>2</sub>-Al-MIL-101 International Journal of Molecular Sciences NH<sub>2</sub>-Al-MIL-101 controlled release dual encapsulation synergistic effect rice sheath blight |
| title | Enhanced Fungicidal Efficacy by Co-Delivery of Azoxystrobin and Diniconazole with Cauliflower-Like Metal–Organic Frameworks NH<sub>2</sub>-Al-MIL-101 |
| title_full | Enhanced Fungicidal Efficacy by Co-Delivery of Azoxystrobin and Diniconazole with Cauliflower-Like Metal–Organic Frameworks NH<sub>2</sub>-Al-MIL-101 |
| title_fullStr | Enhanced Fungicidal Efficacy by Co-Delivery of Azoxystrobin and Diniconazole with Cauliflower-Like Metal–Organic Frameworks NH<sub>2</sub>-Al-MIL-101 |
| title_full_unstemmed | Enhanced Fungicidal Efficacy by Co-Delivery of Azoxystrobin and Diniconazole with Cauliflower-Like Metal–Organic Frameworks NH<sub>2</sub>-Al-MIL-101 |
| title_short | Enhanced Fungicidal Efficacy by Co-Delivery of Azoxystrobin and Diniconazole with Cauliflower-Like Metal–Organic Frameworks NH<sub>2</sub>-Al-MIL-101 |
| title_sort | enhanced fungicidal efficacy by co delivery of azoxystrobin and diniconazole with cauliflower like metal organic frameworks nh sub 2 sub al mil 101 |
| topic | NH<sub>2</sub>-Al-MIL-101 controlled release dual encapsulation synergistic effect rice sheath blight |
| url | https://www.mdpi.com/1422-0067/22/19/10412 |
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