Short-term Effects of Cardiopulmonary Bypass Case Series Temperature on Intracardiac Repair for Tetralogy of Fallot: A Retrospective Single Centre Observational Study
Introduction: Tetralogy of Fallot (TOF) is a common cyanotic disease and the concept of ideal Cardiopulmonary Bypass (CPB) temperature is still controversial. Aim: To assess the merits and demerits in terms of short term patient outcome of normothermic CPB over hypothermic CPB during intracardiac re...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2019-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/12513/38346_CE[Ra1]_F(AC)_PF1(AGAK)_PFA(AK)_PB(AG_SHU)_PN(SL).pdf |
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| author | AVISHEK SAMADDAR SHYAM KUMAR SINGH THINGNAM VIRENDRA KUMAR ARYA MANOJ KUMAR ROHIT HARKANT SINGH TOUSIF KHAN VIVEK JASWAL |
| author_facet | AVISHEK SAMADDAR SHYAM KUMAR SINGH THINGNAM VIRENDRA KUMAR ARYA MANOJ KUMAR ROHIT HARKANT SINGH TOUSIF KHAN VIVEK JASWAL |
| author_sort | AVISHEK SAMADDAR |
| collection | DOAJ |
| description | Introduction: Tetralogy of Fallot (TOF) is a common cyanotic disease and the concept of ideal Cardiopulmonary Bypass (CPB) temperature is still controversial. Aim: To assess the merits and demerits in terms of short term patient outcome of normothermic CPB over hypothermic CPB during intracardiac repair of TOF amongst paediatric patients. Materials and Methods: Among 71 patients of TOF who underwent Intracardiac Repair (ICR) in the Department of Cardiovascular and Thoracic Surgery from 1st January, 2016 to 30th April, 2017, 60 patients were included in our single centre retrospective observational study. Normally distributed variables were expressed by their mean and standard deviation; non normally distributed variables were expressed by their medians and interquartile ranges; categorical variables were expressed as n (%). Statistical software Stata IC version 14, R version 3.2.1 and MedCal were used. All tests were two-tailed with level of significance as <0.05. Results: Normothermic CPB resulted in reduced post-operative Intensive Care Unit (ICU) and hospital stay, lesser incidence of delayed extubation and post-operative Right Ventricular (RV) dysfunction and lesser transfusion requirements of Fresh Frozen Plasma (FFP). (p<0.05). There was no impact of the CPB temperature on renal function, mean blood sugar levels, coagulation parameter and post-operative drain output, postoperative fever, wound infection, arrhythmia or re-exploration. Conclusion: ICR for TOF under normothermic CPB is feasible and results in better post-operative outcomes in terms of duration of ventilation, ICU and hospital stay and RV functions. |
| first_indexed | 2024-12-16T11:00:21Z |
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| id | doaj.art-8bf8169eb2c645d58185c3a837b6d114 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-16T11:00:21Z |
| publishDate | 2019-01-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-8bf8169eb2c645d58185c3a837b6d1142022-12-21T22:34:01ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2019-01-01131SC01SC0610.7860/JCDR/2019/38346.12513Short-term Effects of Cardiopulmonary Bypass Case Series Temperature on Intracardiac Repair for Tetralogy of Fallot: A Retrospective Single Centre Observational StudyAVISHEK SAMADDAR0SHYAM KUMAR SINGH THINGNAM1VIRENDRA KUMAR ARYA2MANOJ KUMAR ROHIT3HARKANT SINGH4TOUSIF KHAN5VIVEK JASWAL6Senior Resident, Department of CTVS, Post Graduate Institute of Medical Education and Research, Chandigarh, India.Professor, Department of CTVS, Post Graduate Institute of Medical Education and Research, Chandigarh, India.Professor, Department of Cardiac Anaesthesia, Post Graduate Institute of Medical Education and Research, Chandigarh, IndiaProfessor, Department of Cardiac Anaesthesia, Post Graduate Institute of Medical Education and Research, Chandigarh, India.Professor, Department of CTVS, Post Graduate Institute of Medical Education and Research, Chandigarh, India.Senior Resident, Department of CTVS, Post Graduate Institute of Medical Education and Research, Chandigarh, India.Senior Resident, Department of CTVS, Post Graduate Institute of Medical Education and Research, Chandigarh, India.Introduction: Tetralogy of Fallot (TOF) is a common cyanotic disease and the concept of ideal Cardiopulmonary Bypass (CPB) temperature is still controversial. Aim: To assess the merits and demerits in terms of short term patient outcome of normothermic CPB over hypothermic CPB during intracardiac repair of TOF amongst paediatric patients. Materials and Methods: Among 71 patients of TOF who underwent Intracardiac Repair (ICR) in the Department of Cardiovascular and Thoracic Surgery from 1st January, 2016 to 30th April, 2017, 60 patients were included in our single centre retrospective observational study. Normally distributed variables were expressed by their mean and standard deviation; non normally distributed variables were expressed by their medians and interquartile ranges; categorical variables were expressed as n (%). Statistical software Stata IC version 14, R version 3.2.1 and MedCal were used. All tests were two-tailed with level of significance as <0.05. Results: Normothermic CPB resulted in reduced post-operative Intensive Care Unit (ICU) and hospital stay, lesser incidence of delayed extubation and post-operative Right Ventricular (RV) dysfunction and lesser transfusion requirements of Fresh Frozen Plasma (FFP). (p<0.05). There was no impact of the CPB temperature on renal function, mean blood sugar levels, coagulation parameter and post-operative drain output, postoperative fever, wound infection, arrhythmia or re-exploration. Conclusion: ICR for TOF under normothermic CPB is feasible and results in better post-operative outcomes in terms of duration of ventilation, ICU and hospital stay and RV functions.https://jcdr.net/articles/PDF/12513/38346_CE[Ra1]_F(AC)_PF1(AGAK)_PFA(AK)_PB(AG_SHU)_PN(SL).pdfcongenital heart diseasehypothermianormothermia |
| spellingShingle | AVISHEK SAMADDAR SHYAM KUMAR SINGH THINGNAM VIRENDRA KUMAR ARYA MANOJ KUMAR ROHIT HARKANT SINGH TOUSIF KHAN VIVEK JASWAL Short-term Effects of Cardiopulmonary Bypass Case Series Temperature on Intracardiac Repair for Tetralogy of Fallot: A Retrospective Single Centre Observational Study Journal of Clinical and Diagnostic Research congenital heart disease hypothermia normothermia |
| title | Short-term Effects of Cardiopulmonary Bypass Case Series Temperature on Intracardiac Repair for Tetralogy of Fallot: A Retrospective Single Centre Observational Study |
| title_full | Short-term Effects of Cardiopulmonary Bypass Case Series Temperature on Intracardiac Repair for Tetralogy of Fallot: A Retrospective Single Centre Observational Study |
| title_fullStr | Short-term Effects of Cardiopulmonary Bypass Case Series Temperature on Intracardiac Repair for Tetralogy of Fallot: A Retrospective Single Centre Observational Study |
| title_full_unstemmed | Short-term Effects of Cardiopulmonary Bypass Case Series Temperature on Intracardiac Repair for Tetralogy of Fallot: A Retrospective Single Centre Observational Study |
| title_short | Short-term Effects of Cardiopulmonary Bypass Case Series Temperature on Intracardiac Repair for Tetralogy of Fallot: A Retrospective Single Centre Observational Study |
| title_sort | short term effects of cardiopulmonary bypass case series temperature on intracardiac repair for tetralogy of fallot a retrospective single centre observational study |
| topic | congenital heart disease hypothermia normothermia |
| url | https://jcdr.net/articles/PDF/12513/38346_CE[Ra1]_F(AC)_PF1(AGAK)_PFA(AK)_PB(AG_SHU)_PN(SL).pdf |
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