Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma
<p>Abstract</p> <p>Purpose</p> <p>This study explores whether meningioma expresses epidermal growth factor receptor (EGFR) and determines if there is a correlation between the WHO grade of this tumor and the degree of EGFR expression.</p> <p>Methods</p>...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-05-01
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| Series: | Radiation Oncology |
| Online Access: | http://www.ro-journal.com/content/5/1/46 |
| _version_ | 1811318015551078400 |
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| author | Perry Arie Hammond Elizabeth H Hyslop Terry Ivanidze Jana Whiton Michal Dicker Adam P Wernicke A Gabriella Andrews David W Kenyon Lawrence |
| author_facet | Perry Arie Hammond Elizabeth H Hyslop Terry Ivanidze Jana Whiton Michal Dicker Adam P Wernicke A Gabriella Andrews David W Kenyon Lawrence |
| author_sort | Perry Arie |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Purpose</p> <p>This study explores whether meningioma expresses epidermal growth factor receptor (EGFR) and determines if there is a correlation between the WHO grade of this tumor and the degree of EGFR expression.</p> <p>Methods</p> <p>Following institutional review board approval, 113 meningioma specimens from 89 patients were chosen. Of these, 85 were used for final analysis. After a blinded review, immunohistochemical stains for EGFR were performed. Staining intensity (SI) was scored on a scale 0-3 (from no staining to strong staining). Staining percentage of immunoreactive cells (SP) was scored 1-5 (from the least to the maximum percent of the specimen staining). Immunohistochemical score (IHS) was calculated as the product of SI and SP.</p> <p>Results</p> <p>Eighty-five samples of meningioma were classified in accordance with World Health Organization (WHO) criteria: benign 57/85 (67%), atypical 23/85 (27%), and malignant 5/85 (6%). The majority of samples demonstrated a moderate SI for EGFR. IHS for EGFR demonstrated a significant association between SI and histopathologic subtype. Also, there was a correlation between the SP and histopathologic subtype (p = 0.029). A significant association was determined when the benign and the atypical samples were compared to the malignant with respect to the SP (p = 0.009). While there was a range of the IHS for the benign and the atypical histologic subtypes, malignant tumors exhibited the lowest score and were statistically different from the benign and the atypical specimens (p < 0.001).</p> <p>Conclusions</p> <p>To our knowledge, this represents the largest series of meningioma samples analyzed for EGFR expression reported in the literature. EGFR expression is greatest in benign meningiomas and may serve a potential target for therapeutic intervention with selective EGFR inhibitors.</p> |
| first_indexed | 2024-04-13T12:18:36Z |
| format | Article |
| id | doaj.art-8bf94d45a8f14639a60c82d3ab5460a2 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-13T12:18:36Z |
| publishDate | 2010-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-8bf94d45a8f14639a60c82d3ab5460a22022-12-22T02:47:17ZengBMCRadiation Oncology1748-717X2010-05-01514610.1186/1748-717X-5-46Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningiomaPerry ArieHammond Elizabeth HHyslop TerryIvanidze JanaWhiton MichalDicker Adam PWernicke A GabriellaAndrews David WKenyon Lawrence<p>Abstract</p> <p>Purpose</p> <p>This study explores whether meningioma expresses epidermal growth factor receptor (EGFR) and determines if there is a correlation between the WHO grade of this tumor and the degree of EGFR expression.</p> <p>Methods</p> <p>Following institutional review board approval, 113 meningioma specimens from 89 patients were chosen. Of these, 85 were used for final analysis. After a blinded review, immunohistochemical stains for EGFR were performed. Staining intensity (SI) was scored on a scale 0-3 (from no staining to strong staining). Staining percentage of immunoreactive cells (SP) was scored 1-5 (from the least to the maximum percent of the specimen staining). Immunohistochemical score (IHS) was calculated as the product of SI and SP.</p> <p>Results</p> <p>Eighty-five samples of meningioma were classified in accordance with World Health Organization (WHO) criteria: benign 57/85 (67%), atypical 23/85 (27%), and malignant 5/85 (6%). The majority of samples demonstrated a moderate SI for EGFR. IHS for EGFR demonstrated a significant association between SI and histopathologic subtype. Also, there was a correlation between the SP and histopathologic subtype (p = 0.029). A significant association was determined when the benign and the atypical samples were compared to the malignant with respect to the SP (p = 0.009). While there was a range of the IHS for the benign and the atypical histologic subtypes, malignant tumors exhibited the lowest score and were statistically different from the benign and the atypical specimens (p < 0.001).</p> <p>Conclusions</p> <p>To our knowledge, this represents the largest series of meningioma samples analyzed for EGFR expression reported in the literature. EGFR expression is greatest in benign meningiomas and may serve a potential target for therapeutic intervention with selective EGFR inhibitors.</p>http://www.ro-journal.com/content/5/1/46 |
| spellingShingle | Perry Arie Hammond Elizabeth H Hyslop Terry Ivanidze Jana Whiton Michal Dicker Adam P Wernicke A Gabriella Andrews David W Kenyon Lawrence Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma Radiation Oncology |
| title | Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma |
| title_full | Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma |
| title_fullStr | Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma |
| title_full_unstemmed | Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma |
| title_short | Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma |
| title_sort | assessment of epidermal growth factor receptor egfr expression in human meningioma |
| url | http://www.ro-journal.com/content/5/1/46 |
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