Quantification of spatial pharmacogene expression heterogeneity in breast tumors

Quantification of spatial pharmacogene expression heterogeneity in breast tumors

Abstract Background Chemotherapeutic drug concentrations vary across different regions of tumors and this is thought to be involved in development of chemotherapy resistance. Insufficient drug delivery to some regions of the tumor may be due to spatial differences in expression of genes involved in...

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Bibliographic Details
Main Authors: Nicholas R. Powell, Rebecca M. Silvola, John S. Howard, Sunil Badve, Todd C. Skaar, Joseph Ipe
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Cancer Reports
Subjects:
chemotherapy
pharmacogene
resistance
spatial
transcriptomics
Online Access:https://doi.org/10.1002/cnr2.1686

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