Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study
Abstract Background Osteoporosis is a major public health problem, yet the association between dietary folate intake and bone health has been rarely studied. This study aimed to investigate the relationship between dietary folate intake and bone mineral density (BMD) in the general population of the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-04188-4 |
| _version_ | 1797557818132267008 |
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| author | Zitian Zheng Huanhuan Luo Wennan Xu Qingyun Xue |
| author_facet | Zitian Zheng Huanhuan Luo Wennan Xu Qingyun Xue |
| author_sort | Zitian Zheng |
| collection | DOAJ |
| description | Abstract Background Osteoporosis is a major public health problem, yet the association between dietary folate intake and bone health has been rarely studied. This study aimed to investigate the relationship between dietary folate intake and bone mineral density (BMD) in the general population of the USA. Methods Utilizing data from the National Health and Nutrition Examination Survey, dietary folate intake was gauged through 24-h dietary recall and BMD was determined via dual-energy X-ray absorptiometry. Multivariate linear regression models and generalized additive models were employed for correlation analysis. Results The study incorporated 9839 participants (48.88% males, aged 20–85 years, mean age: 47.62 ± 16.22). The average dietary folate intake stood at 401.1 ± 207.9 μg/day. And the average total femur, femoral neck, trochanter, intertrochanter, and lumbar BMD were 0.98 ± 0.16 g/cm2, 0.84 ± 0.15 g/cm2, 0.73 ± 0.13 g/cm2, 1.16 ± 0.19 g/cm2, and 1.03 ± 0.15 g/cm2, respectively. The higher quartiles of dietary folate intake directly correlated with increased total femoral, femoral neck, intertrochanteric, and lumbar BMD (P for trend = 0.003, 0.016, < 0.001, and 0.033, respectively). A consistent positive association between folate intake and BMD across age groups was observed, with significant findings for individuals over 80 years and non-Hispanic whites. Physical activity level and serum 25-hydroxyvitamin D levels influenced the association, with an optimal daily folate intake of 528–569 µg recommended for postmenopausal women. Conclusion In summary, our study reveals a significant positive association between dietary folate intake and BMD, across different age groups and particularly among individuals over 80 years old. Non-Hispanic whites benefit the most from increased folate intake. Physical activity level and serum 25-hydroxyvitamin D levels interact with this association. Screening and early intervention for osteoporosis may be essential for individuals with low dietary folate intake. |
| first_indexed | 2024-03-10T17:21:34Z |
| format | Article |
| id | doaj.art-8bfb94eff36f4990996ebfc356080288 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-10T17:21:34Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-8bfb94eff36f4990996ebfc3560802882023-11-20T10:20:03ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-09-0118111410.1186/s13018-023-04188-4Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional studyZitian Zheng0Huanhuan Luo1Wennan Xu2Qingyun Xue3Department of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of Nursing, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical ScienceDepartment of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesAbstract Background Osteoporosis is a major public health problem, yet the association between dietary folate intake and bone health has been rarely studied. This study aimed to investigate the relationship between dietary folate intake and bone mineral density (BMD) in the general population of the USA. Methods Utilizing data from the National Health and Nutrition Examination Survey, dietary folate intake was gauged through 24-h dietary recall and BMD was determined via dual-energy X-ray absorptiometry. Multivariate linear regression models and generalized additive models were employed for correlation analysis. Results The study incorporated 9839 participants (48.88% males, aged 20–85 years, mean age: 47.62 ± 16.22). The average dietary folate intake stood at 401.1 ± 207.9 μg/day. And the average total femur, femoral neck, trochanter, intertrochanter, and lumbar BMD were 0.98 ± 0.16 g/cm2, 0.84 ± 0.15 g/cm2, 0.73 ± 0.13 g/cm2, 1.16 ± 0.19 g/cm2, and 1.03 ± 0.15 g/cm2, respectively. The higher quartiles of dietary folate intake directly correlated with increased total femoral, femoral neck, intertrochanteric, and lumbar BMD (P for trend = 0.003, 0.016, < 0.001, and 0.033, respectively). A consistent positive association between folate intake and BMD across age groups was observed, with significant findings for individuals over 80 years and non-Hispanic whites. Physical activity level and serum 25-hydroxyvitamin D levels influenced the association, with an optimal daily folate intake of 528–569 µg recommended for postmenopausal women. Conclusion In summary, our study reveals a significant positive association between dietary folate intake and BMD, across different age groups and particularly among individuals over 80 years old. Non-Hispanic whites benefit the most from increased folate intake. Physical activity level and serum 25-hydroxyvitamin D levels interact with this association. Screening and early intervention for osteoporosis may be essential for individuals with low dietary folate intake.https://doi.org/10.1186/s13018-023-04188-4Dietary folate intakeBone mineral densityNonlinear relationshipCross-sectional |
| spellingShingle | Zitian Zheng Huanhuan Luo Wennan Xu Qingyun Xue Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study Journal of Orthopaedic Surgery and Research Dietary folate intake Bone mineral density Nonlinear relationship Cross-sectional |
| title | Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study |
| title_full | Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study |
| title_fullStr | Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study |
| title_full_unstemmed | Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study |
| title_short | Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study |
| title_sort | association between dietary folate intake and bone mineral density in a diverse population a cross sectional study |
| topic | Dietary folate intake Bone mineral density Nonlinear relationship Cross-sectional |
| url | https://doi.org/10.1186/s13018-023-04188-4 |
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