Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies
Skeletal muscle (SM) comprises around 40% of total body weight and is among the most important plastic tissues, as it supports skeletal development, controls body temperature, and manages glucose levels. Extracellular matrix (ECM) maintains the integrity of SM, enables biochemical signaling, provide...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.00142/full |
| _version_ | 1818476189773201408 |
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| author | Khurshid Ahmad Sibhghatulla Shaikh Syed Sayeed Ahmad Eun Ju Lee Inho Choi |
| author_facet | Khurshid Ahmad Sibhghatulla Shaikh Syed Sayeed Ahmad Eun Ju Lee Inho Choi |
| author_sort | Khurshid Ahmad |
| collection | DOAJ |
| description | Skeletal muscle (SM) comprises around 40% of total body weight and is among the most important plastic tissues, as it supports skeletal development, controls body temperature, and manages glucose levels. Extracellular matrix (ECM) maintains the integrity of SM, enables biochemical signaling, provides structural support, and plays a vital role during myogenesis. Several human diseases are coupled with dysfunctions of the ECM, and several ECM components are involved in disease pathologies that affect almost all organ systems. Thus, mutations in ECM genes that encode proteins and their transmembrane receptors can result in diverse SM diseases, a large proportion of which are types of fibrosis and muscular dystrophy. In this review, we present major ECM components of SMs related to muscle-associated diseases, and discuss two major ECM myopathies, namely, collagen myopathy and laminin myopathies, and their therapeutic managements. A comprehensive understanding of the mechanisms underlying these ECM-related myopathies would undoubtedly aid the discovery of novel treatments for these devastating diseases. |
| first_indexed | 2024-12-10T09:22:14Z |
| format | Article |
| id | doaj.art-8bfdb2fdb15a41a68cd29ecf42194e69 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T09:22:14Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-8bfdb2fdb15a41a68cd29ecf42194e692022-12-22T01:54:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-02-011110.3389/fphar.2020.00142512692Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for MyopathiesKhurshid AhmadSibhghatulla ShaikhSyed Sayeed AhmadEun Ju LeeInho ChoiSkeletal muscle (SM) comprises around 40% of total body weight and is among the most important plastic tissues, as it supports skeletal development, controls body temperature, and manages glucose levels. Extracellular matrix (ECM) maintains the integrity of SM, enables biochemical signaling, provides structural support, and plays a vital role during myogenesis. Several human diseases are coupled with dysfunctions of the ECM, and several ECM components are involved in disease pathologies that affect almost all organ systems. Thus, mutations in ECM genes that encode proteins and their transmembrane receptors can result in diverse SM diseases, a large proportion of which are types of fibrosis and muscular dystrophy. In this review, we present major ECM components of SMs related to muscle-associated diseases, and discuss two major ECM myopathies, namely, collagen myopathy and laminin myopathies, and their therapeutic managements. A comprehensive understanding of the mechanisms underlying these ECM-related myopathies would undoubtedly aid the discovery of novel treatments for these devastating diseases.https://www.frontiersin.org/article/10.3389/fphar.2020.00142/fullcollagenextracellular matrixlamininmyopathyskeletal muscle |
| spellingShingle | Khurshid Ahmad Sibhghatulla Shaikh Syed Sayeed Ahmad Eun Ju Lee Inho Choi Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies Frontiers in Pharmacology collagen extracellular matrix laminin myopathy skeletal muscle |
| title | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
| title_full | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
| title_fullStr | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
| title_full_unstemmed | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
| title_short | Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies |
| title_sort | cross talk between extracellular matrix and skeletal muscle implications for myopathies |
| topic | collagen extracellular matrix laminin myopathy skeletal muscle |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.00142/full |
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