Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest
Background The inflammatory response that occurs following cardiac arrest can determine the long-term prognosis of patients who survive out-of-hospital cardiac arrest. We evaluated the correlation between C-reactive protein-to-albumin ratio (CAR) following cardiac arrest and long-term mortality. Met...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Critical Care Medicine
2022-11-01
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| Series: | Acute and Critical Care |
| Subjects: | |
| Online Access: | http://www.accjournal.org/upload/pdf/acc-2022-00542.pdf |
| _version_ | 1811184405981429760 |
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| author | Hui Hwan Kim Ji Ho Lee Dong Hun Lee Byung Kook Lee |
| author_facet | Hui Hwan Kim Ji Ho Lee Dong Hun Lee Byung Kook Lee |
| author_sort | Hui Hwan Kim |
| collection | DOAJ |
| description | Background The inflammatory response that occurs following cardiac arrest can determine the long-term prognosis of patients who survive out-of-hospital cardiac arrest. We evaluated the correlation between C-reactive protein-to-albumin ratio (CAR) following cardiac arrest and long-term mortality. Methods The current retrospective observational study examined patients with post-cardiac arrest syndrome (PCAS) treated with targeted temperature management at a single tertiary care hospital. We measured CAR at four time points (at admission and then 24 hours, 48 hours, and 72 hours after) following cardiac arrest. The primary outcome was the patients’ 6-month mortality. We performed multivariable and area under the receiver operating characteristic curve (AUC) analyses to investigate the relationship between CAR and 6-month mortality. Results Among the 115 patients, 52 (44.1%) died within 6 months. In the multivariable analysis, CAR at 48 hours (odds ratio [OR], 1.130; 95% confidence interval [CI], 1.027–1.244) and 72 hours (OR, 1.241; 95% CI, 1.059–1.455) after cardiac arrest was independently associated with 6-month mortality. The AUCs of CAR at admission and 24, 48, and 72 hours after cardiac arrest for predicting 6-month mortality were 0.583 (95% CI, 0.489–0.673), 0.622 (95% CI, 0.528–0.710), 0.706 (95% CI, 0.615–0.786), and 0.762 (95% CI, 0.675–0.835), respectively. Conclusions CAR at 72 hours after cardiac arrest was an independent predictor for long-term mortality in patients with PCAS. |
| first_indexed | 2024-04-11T13:12:41Z |
| format | Article |
| id | doaj.art-8bfe291519a84dd1b6c7dbba00415b7a |
| institution | Directory Open Access Journal |
| issn | 2586-6052 2586-6060 |
| language | English |
| last_indexed | 2024-04-11T13:12:41Z |
| publishDate | 2022-11-01 |
| publisher | Korean Society of Critical Care Medicine |
| record_format | Article |
| series | Acute and Critical Care |
| spelling | doaj.art-8bfe291519a84dd1b6c7dbba00415b7a2022-12-22T04:22:33ZengKorean Society of Critical Care MedicineAcute and Critical Care2586-60522586-60602022-11-0137460160910.4266/acc.2022.005421403Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrestHui Hwan Kim0Ji Ho Lee1Dong Hun Lee2Byung Kook Lee3 Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, KoreaBackground The inflammatory response that occurs following cardiac arrest can determine the long-term prognosis of patients who survive out-of-hospital cardiac arrest. We evaluated the correlation between C-reactive protein-to-albumin ratio (CAR) following cardiac arrest and long-term mortality. Methods The current retrospective observational study examined patients with post-cardiac arrest syndrome (PCAS) treated with targeted temperature management at a single tertiary care hospital. We measured CAR at four time points (at admission and then 24 hours, 48 hours, and 72 hours after) following cardiac arrest. The primary outcome was the patients’ 6-month mortality. We performed multivariable and area under the receiver operating characteristic curve (AUC) analyses to investigate the relationship between CAR and 6-month mortality. Results Among the 115 patients, 52 (44.1%) died within 6 months. In the multivariable analysis, CAR at 48 hours (odds ratio [OR], 1.130; 95% confidence interval [CI], 1.027–1.244) and 72 hours (OR, 1.241; 95% CI, 1.059–1.455) after cardiac arrest was independently associated with 6-month mortality. The AUCs of CAR at admission and 24, 48, and 72 hours after cardiac arrest for predicting 6-month mortality were 0.583 (95% CI, 0.489–0.673), 0.622 (95% CI, 0.528–0.710), 0.706 (95% CI, 0.615–0.786), and 0.762 (95% CI, 0.675–0.835), respectively. Conclusions CAR at 72 hours after cardiac arrest was an independent predictor for long-term mortality in patients with PCAS.http://www.accjournal.org/upload/pdf/acc-2022-00542.pdfalbuminc-reactive proteincardiac arrestmortalityprognosis |
| spellingShingle | Hui Hwan Kim Ji Ho Lee Dong Hun Lee Byung Kook Lee Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest Acute and Critical Care albumin c-reactive protein cardiac arrest mortality prognosis |
| title | Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest |
| title_full | Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest |
| title_fullStr | Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest |
| title_full_unstemmed | Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest |
| title_short | Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest |
| title_sort | association between c reactive protein to albumin ratio and 6 month mortality in out of hospital cardiac arrest |
| topic | albumin c-reactive protein cardiac arrest mortality prognosis |
| url | http://www.accjournal.org/upload/pdf/acc-2022-00542.pdf |
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