Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study
Abstract Background The interplay between physical activity (PA) and air pollution in relation to type 2 diabetes (T2D) remains largely unknown. Based on a large population-based cohort study, this study aimed to examine whether the benefits of PA with respect to the risk of T2D are moderated by exp...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-022-00922-3 |
| _version_ | 1828197894112411648 |
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| author | Zhi-Hao Li Wen-Fang Zhong Xi-Ru Zhang Vincent CH Chung Wei-Qi Song Qing Chen Xiao-Meng Wang Qing-Mei Huang Dong Shen Pei-Dong Zhang Dan Liu Yu-Jie Zhang Pei-Liang Chen Xin Cheng Hai-Lian Yang Miao-Chun Cai Xiang Gao Virginia Byers Kraus Chen Mao |
| author_facet | Zhi-Hao Li Wen-Fang Zhong Xi-Ru Zhang Vincent CH Chung Wei-Qi Song Qing Chen Xiao-Meng Wang Qing-Mei Huang Dong Shen Pei-Dong Zhang Dan Liu Yu-Jie Zhang Pei-Liang Chen Xin Cheng Hai-Lian Yang Miao-Chun Cai Xiang Gao Virginia Byers Kraus Chen Mao |
| author_sort | Zhi-Hao Li |
| collection | DOAJ |
| description | Abstract Background The interplay between physical activity (PA) and air pollution in relation to type 2 diabetes (T2D) remains largely unknown. Based on a large population-based cohort study, this study aimed to examine whether the benefits of PA with respect to the risk of T2D are moderated by exposure to air pollution. Methods UK Biobank participants (n = 359,153) without diabetes at baseline were included. Information on PA was obtained using the International Physical Activity Questionnaire short form. Exposure to air pollution, including PM2.5, PMcoarse (PM2.5−10), PM10, and NO2, was estimated from land use regression models. Cox regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs). Results During a median of 8.9 years of follow-up, 13,706 T2D events were recorded. Compared with a low PA level, the HRs for the risk of T2D among individuals with moderate and high PA were 0.82 (95% CI, 0.79–0.86) and 0.73 (95% CI, 0.70–0.77), respectively. Compared with low levels of air pollution, the HRs for risk of T2D for high levels of air pollution (PM2.5, PMcoarse, PM10, and NO2) were 1.19 (1.14–1.24), 1.06 (1.02–1.11), 1.13 (1.08–1.18), and 1.19 (1.14–1.24), respectively. There was no effect modification of the associations between PA and T2D by air pollution (all P-interactions > 0.05). The inverse associations between PA and T2D in each air pollution stratum were generally consistent (all P for trend < 0.05). Conclusion A higher PA and lower air pollution level were independently associated with a lower risk of T2D. The beneficial effects of PA on T2D generally remained stable among participants exposed to different levels of air pollution. Further studies are needed to replicate our findings in moderately and severely polluted areas. |
| first_indexed | 2024-04-12T10:27:06Z |
| format | Article |
| id | doaj.art-8bfe635e24814bfaa74626348c3107de |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-04-12T10:27:06Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-8bfe635e24814bfaa74626348c3107de2022-12-22T03:36:56ZengBMCEnvironmental Health1476-069X2022-11-0121111210.1186/s12940-022-00922-3Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort studyZhi-Hao Li0Wen-Fang Zhong1Xi-Ru Zhang2Vincent CH Chung3Wei-Qi Song4Qing Chen5Xiao-Meng Wang6Qing-Mei Huang7Dong Shen8Pei-Dong Zhang9Dan Liu10Yu-Jie Zhang11Pei-Liang Chen12Xin Cheng13Hai-Lian Yang14Miao-Chun Cai15Xiang Gao16Virginia Byers Kraus17Chen Mao18Department of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityJockey Club School of Public Health and Primary Care, The Chinese University of Hong KongDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Nutritional Sciences, The Pennsylvania State UniversityDuke Molecular Physiology Institute, Division of Rheumatology, Department of Medicine, Duke University School of MedicineDepartment of Epidemiology, School of Public Health, Southern Medical UniversityAbstract Background The interplay between physical activity (PA) and air pollution in relation to type 2 diabetes (T2D) remains largely unknown. Based on a large population-based cohort study, this study aimed to examine whether the benefits of PA with respect to the risk of T2D are moderated by exposure to air pollution. Methods UK Biobank participants (n = 359,153) without diabetes at baseline were included. Information on PA was obtained using the International Physical Activity Questionnaire short form. Exposure to air pollution, including PM2.5, PMcoarse (PM2.5−10), PM10, and NO2, was estimated from land use regression models. Cox regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs). Results During a median of 8.9 years of follow-up, 13,706 T2D events were recorded. Compared with a low PA level, the HRs for the risk of T2D among individuals with moderate and high PA were 0.82 (95% CI, 0.79–0.86) and 0.73 (95% CI, 0.70–0.77), respectively. Compared with low levels of air pollution, the HRs for risk of T2D for high levels of air pollution (PM2.5, PMcoarse, PM10, and NO2) were 1.19 (1.14–1.24), 1.06 (1.02–1.11), 1.13 (1.08–1.18), and 1.19 (1.14–1.24), respectively. There was no effect modification of the associations between PA and T2D by air pollution (all P-interactions > 0.05). The inverse associations between PA and T2D in each air pollution stratum were generally consistent (all P for trend < 0.05). Conclusion A higher PA and lower air pollution level were independently associated with a lower risk of T2D. The beneficial effects of PA on T2D generally remained stable among participants exposed to different levels of air pollution. Further studies are needed to replicate our findings in moderately and severely polluted areas.https://doi.org/10.1186/s12940-022-00922-3Physical activityAir pollutionType 2 diabetesCohort study |
| spellingShingle | Zhi-Hao Li Wen-Fang Zhong Xi-Ru Zhang Vincent CH Chung Wei-Qi Song Qing Chen Xiao-Meng Wang Qing-Mei Huang Dong Shen Pei-Dong Zhang Dan Liu Yu-Jie Zhang Pei-Liang Chen Xin Cheng Hai-Lian Yang Miao-Chun Cai Xiang Gao Virginia Byers Kraus Chen Mao Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study Environmental Health Physical activity Air pollution Type 2 diabetes Cohort study |
| title | Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study |
| title_full | Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study |
| title_fullStr | Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study |
| title_full_unstemmed | Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study |
| title_short | Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study |
| title_sort | association of physical activity and air pollution exposure with the risk of type 2 diabetes a large population based prospective cohort study |
| topic | Physical activity Air pollution Type 2 diabetes Cohort study |
| url | https://doi.org/10.1186/s12940-022-00922-3 |
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