The Assessment of Complement Proteins in Patients With Severe COVID-19
Introduction: The complement system, consisting of more than 20 soluble proteins, has a crucial role in innate immunity and inflammation and eliminates pathogens and viral infections. Therefore, we investigated the titers of C3, C4, and total IgG in the sera of non-severe and severe coronavirus dise...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Zabol University of Medical sciences
2021-12-01
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| Series: | International Journal of Basic Science in Medicine |
| Subjects: | |
| Online Access: | https://ijbsm.zbmu.ac.ir/PDF/ijbsm-6-152.pdf |
| _version_ | 1811303940992532480 |
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| author | Ali Ghazavi Ghasem Mosayebi Nafiesh Keshavarzian Somayeh Rabiemajd Ali Ganji |
| author_facet | Ali Ghazavi Ghasem Mosayebi Nafiesh Keshavarzian Somayeh Rabiemajd Ali Ganji |
| author_sort | Ali Ghazavi |
| collection | DOAJ |
| description | Introduction: The complement system, consisting of more than 20 soluble proteins, has a crucial role in innate immunity and inflammation and eliminates pathogens and viral infections. Therefore, we investigated the titers of C3, C4, and total IgG in the sera of non-severe and severe coronavirus disease 2019 (COVID-19) patients. Methods: For this purpose, peripheral blood samples were collected from 30 non-severe and 30 severe COVID-19 patients and 30 healthy individuals with similar age and sex as the control group. The serum levels of total IgG, C3, and C4 were analyzed. Also, white blood cells, platelets (PLTs), and lymphocytes were counted by an auto-analyzer. Results: White blood cell count showed no difference between COVID-19 patients and the control group. The results showed a significant decrease in lymphocyte and PLT counts in COVID-19 patients compared to the control. Complement proteins, including C3 and C4, were increased in non-severe COVID-19 patients (C3; P=0.017 and C4; P=0.012) compared to other groups. Total IgG showed a notable decrease in severe COVID-19 patients. Conclusion: The decrease in C3 and C4 complement factors in severe COVID-19 patients may be due to further consumption secondary to the formation of immune complexes. By clarifying the role of complement proteins of C3 and C4 in different stages of the disease, our results can be helpful in designing therapeutic and diagnostic measures for the disease. |
| first_indexed | 2024-04-13T07:56:58Z |
| format | Article |
| id | doaj.art-8bfe8abb858042478eb8aa1957a51745 |
| institution | Directory Open Access Journal |
| issn | 2476-664X |
| language | English |
| last_indexed | 2024-04-13T07:56:58Z |
| publishDate | 2021-12-01 |
| publisher | Zabol University of Medical sciences |
| record_format | Article |
| series | International Journal of Basic Science in Medicine |
| spelling | doaj.art-8bfe8abb858042478eb8aa1957a517452022-12-22T02:55:22ZengZabol University of Medical sciencesInternational Journal of Basic Science in Medicine2476-664X2021-12-016415215610.34172/ijbsm.2021.27ijbsm-22516The Assessment of Complement Proteins in Patients With Severe COVID-19Ali Ghazavi0Ghasem Mosayebi1Nafiesh Keshavarzian2Somayeh Rabiemajd3Ali Ganji4Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, IranMolecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, IranMolecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, IranDepartment of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, IranMolecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, IranIntroduction: The complement system, consisting of more than 20 soluble proteins, has a crucial role in innate immunity and inflammation and eliminates pathogens and viral infections. Therefore, we investigated the titers of C3, C4, and total IgG in the sera of non-severe and severe coronavirus disease 2019 (COVID-19) patients. Methods: For this purpose, peripheral blood samples were collected from 30 non-severe and 30 severe COVID-19 patients and 30 healthy individuals with similar age and sex as the control group. The serum levels of total IgG, C3, and C4 were analyzed. Also, white blood cells, platelets (PLTs), and lymphocytes were counted by an auto-analyzer. Results: White blood cell count showed no difference between COVID-19 patients and the control group. The results showed a significant decrease in lymphocyte and PLT counts in COVID-19 patients compared to the control. Complement proteins, including C3 and C4, were increased in non-severe COVID-19 patients (C3; P=0.017 and C4; P=0.012) compared to other groups. Total IgG showed a notable decrease in severe COVID-19 patients. Conclusion: The decrease in C3 and C4 complement factors in severe COVID-19 patients may be due to further consumption secondary to the formation of immune complexes. By clarifying the role of complement proteins of C3 and C4 in different stages of the disease, our results can be helpful in designing therapeutic and diagnostic measures for the disease.https://ijbsm.zbmu.ac.ir/PDF/ijbsm-6-152.pdfcovid-19complementc3c4igginflammation |
| spellingShingle | Ali Ghazavi Ghasem Mosayebi Nafiesh Keshavarzian Somayeh Rabiemajd Ali Ganji The Assessment of Complement Proteins in Patients With Severe COVID-19 International Journal of Basic Science in Medicine covid-19 complement c3 c4 igg inflammation |
| title | The Assessment of Complement Proteins in Patients With Severe COVID-19 |
| title_full | The Assessment of Complement Proteins in Patients With Severe COVID-19 |
| title_fullStr | The Assessment of Complement Proteins in Patients With Severe COVID-19 |
| title_full_unstemmed | The Assessment of Complement Proteins in Patients With Severe COVID-19 |
| title_short | The Assessment of Complement Proteins in Patients With Severe COVID-19 |
| title_sort | assessment of complement proteins in patients with severe covid 19 |
| topic | covid-19 complement c3 c4 igg inflammation |
| url | https://ijbsm.zbmu.ac.ir/PDF/ijbsm-6-152.pdf |
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