Nucleic acid amphiphiles: Synthesis, properties, and applications
Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups, have been widely used in programmable bioengineering. Since nucleic acids are intrinsically hydrophilic, the hydrophobic groups endow nucleic acid amphiphiles with unique properties, such as self-assembling,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253123001397 |
| _version_ | 1797786579212697600 |
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| author | Amu Gubu Xueli Zhang Aiping Lu Baoting Zhang Yuan Ma Ge Zhang |
| author_facet | Amu Gubu Xueli Zhang Aiping Lu Baoting Zhang Yuan Ma Ge Zhang |
| author_sort | Amu Gubu |
| collection | DOAJ |
| description | Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups, have been widely used in programmable bioengineering. Since nucleic acids are intrinsically hydrophilic, the hydrophobic groups endow nucleic acid amphiphiles with unique properties, such as self-assembling, interactions with artificial or biological membranes, and transmembrane transport. Importantly, the hybridization or target binding capability of oligonucleotide itself supplies nucleic acid amphiphiles with excellent programmability. As a result, this type of molecule has attracted considerable attention in academic studies and has enormous potential for further applications. For a comprehensive understanding of nucleic acid amphiphiles, we review the reported research on nucleic acid amphiphiles from their molecular design to final applications, in which we summarize the synthetic strategies for nucleic acid amphiphiles and draw much attention to their unique properties in different contexts. Finally, a summary of the applications of nucleic acid amphiphiles in drug development, bioengineering, and bioanalysis are critically discussed. |
| first_indexed | 2024-03-13T01:09:54Z |
| format | Article |
| id | doaj.art-8c008e579e2847448d58ef97bb57c5f6 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-03-13T01:09:54Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-8c008e579e2847448d58ef97bb57c5f62023-07-06T04:17:38ZengElsevierMolecular Therapy: Nucleic Acids2162-25312023-09-0133144163Nucleic acid amphiphiles: Synthesis, properties, and applicationsAmu Gubu0Xueli Zhang1Aiping Lu2Baoting Zhang3Yuan Ma4Ge Zhang5Law Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China; Aptacure Therapeutics Limited, Kowloon, Hong Kong SAR, ChinaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences and Chemical Biology Center, Peking University, No. 38 Xueyuan Road, Beijing, ChinaLaw Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China; Institute of Integrated Bioinfomedicine and Translational Science, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tsai, Hong Kong 999077, China; Institute of Precision Medicine and Innovative Drug Discovery, HKBU Institute for Research and Continuing Education, Shenzhen 518000, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, ChinaLaw Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China; Institute of Integrated Bioinfomedicine and Translational Science, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tsai, Hong Kong 999077, China; Institute of Precision Medicine and Innovative Drug Discovery, HKBU Institute for Research and Continuing Education, Shenzhen 518000, China; Corresponding author: Yuan Ma, Law Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.Law Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China; Institute of Integrated Bioinfomedicine and Translational Science, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tsai, Hong Kong 999077, China; Institute of Precision Medicine and Innovative Drug Discovery, HKBU Institute for Research and Continuing Education, Shenzhen 518000, China; Corresponding author: Ge Zhang, Law Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups, have been widely used in programmable bioengineering. Since nucleic acids are intrinsically hydrophilic, the hydrophobic groups endow nucleic acid amphiphiles with unique properties, such as self-assembling, interactions with artificial or biological membranes, and transmembrane transport. Importantly, the hybridization or target binding capability of oligonucleotide itself supplies nucleic acid amphiphiles with excellent programmability. As a result, this type of molecule has attracted considerable attention in academic studies and has enormous potential for further applications. For a comprehensive understanding of nucleic acid amphiphiles, we review the reported research on nucleic acid amphiphiles from their molecular design to final applications, in which we summarize the synthetic strategies for nucleic acid amphiphiles and draw much attention to their unique properties in different contexts. Finally, a summary of the applications of nucleic acid amphiphiles in drug development, bioengineering, and bioanalysis are critically discussed.http://www.sciencedirect.com/science/article/pii/S2162253123001397MT: Oligonucleotides: Therapies and Applicationsnucleic acid amphiphileoligonucleotideaptamerself-assemblyliposome |
| spellingShingle | Amu Gubu Xueli Zhang Aiping Lu Baoting Zhang Yuan Ma Ge Zhang Nucleic acid amphiphiles: Synthesis, properties, and applications Molecular Therapy: Nucleic Acids MT: Oligonucleotides: Therapies and Applications nucleic acid amphiphile oligonucleotide aptamer self-assembly liposome |
| title | Nucleic acid amphiphiles: Synthesis, properties, and applications |
| title_full | Nucleic acid amphiphiles: Synthesis, properties, and applications |
| title_fullStr | Nucleic acid amphiphiles: Synthesis, properties, and applications |
| title_full_unstemmed | Nucleic acid amphiphiles: Synthesis, properties, and applications |
| title_short | Nucleic acid amphiphiles: Synthesis, properties, and applications |
| title_sort | nucleic acid amphiphiles synthesis properties and applications |
| topic | MT: Oligonucleotides: Therapies and Applications nucleic acid amphiphile oligonucleotide aptamer self-assembly liposome |
| url | http://www.sciencedirect.com/science/article/pii/S2162253123001397 |
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