Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions
Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6420 |
| _version_ | 1797530063709667328 |
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| author | Himanshu Pandey Mary Popov Alina Goldstein-Levitin Larisa Gheber |
| author_facet | Himanshu Pandey Mary Popov Alina Goldstein-Levitin Larisa Gheber |
| author_sort | Himanshu Pandey |
| collection | DOAJ |
| description | Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin-5 motors, and the mechanisms by which these features relate to kinesin-5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin-5 motors in dividing as well as in non-dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin-5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins. |
| first_indexed | 2024-03-10T10:22:36Z |
| format | Article |
| id | doaj.art-8c01aa62d0ba4815aa22f759e99217a7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:22:36Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8c01aa62d0ba4815aa22f759e99217a72023-11-22T00:15:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212642010.3390/ijms22126420Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular FunctionsHimanshu Pandey0Mary Popov1Alina Goldstein-Levitin2Larisa Gheber3Department of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, IsraelDepartment of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, IsraelDepartment of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, IsraelDepartment of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, IsraelBipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin-5 motors, and the mechanisms by which these features relate to kinesin-5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin-5 motors in dividing as well as in non-dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin-5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins.https://www.mdpi.com/1422-0067/22/12/6420kinesin-5microtubulesmitosiscell-cycle regulation of kinesin activity |
| spellingShingle | Himanshu Pandey Mary Popov Alina Goldstein-Levitin Larisa Gheber Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions International Journal of Molecular Sciences kinesin-5 microtubules mitosis cell-cycle regulation of kinesin activity |
| title | Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions |
| title_full | Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions |
| title_fullStr | Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions |
| title_full_unstemmed | Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions |
| title_short | Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions |
| title_sort | mechanisms by which kinesin 5 motors perform their multiple intracellular functions |
| topic | kinesin-5 microtubules mitosis cell-cycle regulation of kinesin activity |
| url | https://www.mdpi.com/1422-0067/22/12/6420 |
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