Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats.

Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats.

Pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterial hypertension (PAH) show similarities to cancer cells. Due to the growth-suppressive and pro-apoptotic effects of p53 and its inactivation in cancer, we hypothesized that the p53 pathway could be altered in PAH. We therefore explore...

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Bibliographic Details
Main Authors: S Jacquin, V Rincheval, B Mignotte, S Richard, M Humbert, O Mercier, A Londoño-Vallejo, E Fadel, S Eddahibi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4488287?pdf=render

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