The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats

The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats

The impact of the mitochondria-targeted antioxidant MitoQ was evaluated in the cardiac alterations associated with obesity. Male Wistar rats were fed either a high fat diet (HFD, 35% fat) or a standard diet (CT, 3.5% fat) for 7 weeks and treated with MitoQ (200 µM). The effect of MitoQ (5 n...

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Bibliographic Details
Main Authors: Sara Jiménez-González, Gema Marín-Royo, Raquel Jurado-López, María Visitación Bartolomé, Ana Romero-Miranda, María Luaces, Fabián Islas, María Luisa Nieto, Ernesto Martínez-Martínez, Victoria Cachofeiro
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
cardiac fibrosis
cardiac hypertrophy
cardiac lipotoxicity
mitochondrial function
obesity
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/9/2/451

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