Monitoring clusterin and fibrillar structures in aging and dementia
Objective: Clusterin is involved in a variety of physiological processes, including proteostasis. Several clusterin polymorphisms were associated with an increased risk of developing Alzheimer’s disease, the world-leading cause of dementia. Herein, the effect of a clusterin polymorphism, aging and d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Aging Brain |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589958923000178 |
| _version_ | 1797795254014836736 |
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| author | Dário Trindade Maria Cachide Tânia Soares Martins Sandra Guedes Ilka M. Rosa Odete A.B. da Cruz e Silva Ana Gabriela Henriques |
| author_facet | Dário Trindade Maria Cachide Tânia Soares Martins Sandra Guedes Ilka M. Rosa Odete A.B. da Cruz e Silva Ana Gabriela Henriques |
| author_sort | Dário Trindade |
| collection | DOAJ |
| description | Objective: Clusterin is involved in a variety of physiological processes, including proteostasis. Several clusterin polymorphisms were associated with an increased risk of developing Alzheimer’s disease, the world-leading cause of dementia. Herein, the effect of a clusterin polymorphism, aging and dementia in the levels of clusterin in human plasma were analysed in a primary care-based cohort, and the association of this chaperone with fibrillar structures discussed. Methods: 64 individuals with dementia (CDR≥1) and 64 age- and sex-matched Controls from a Portuguese cohort were genotyped for CLU rs1136000 polymorphism, and the plasma levels of clusterin and fibrils were assessed. Results: An increased prevalence of the CC genotype was observed for the dementia group, although no significant robustness was achieved. CLU rs11136000 SNP did not significantly change plasma clusterin levels in demented individuals. Instead, clusterin levels decreased with aging and even more in individuals with dementia. Importantly, plasma clusterin levels correlated with the presence of fibrillar structures in Control individuals, but not in those with dementia. Conclusion: This study reveals a significant decrease in plasma clusterin in demented individuals with aging, which related to altered clusterin-fibrils dynamics. Potentially, plasma clusterin and its association with fibrillar structures can be used to monitor dementia progression along aging. |
| first_indexed | 2024-03-13T03:15:09Z |
| format | Article |
| id | doaj.art-8c02c03ed7d9470d8aafd14802c2e382 |
| institution | Directory Open Access Journal |
| issn | 2589-9589 |
| language | English |
| last_indexed | 2024-03-13T03:15:09Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging Brain |
| spelling | doaj.art-8c02c03ed7d9470d8aafd14802c2e3822023-06-26T04:14:46ZengElsevierAging Brain2589-95892023-01-013100080Monitoring clusterin and fibrillar structures in aging and dementiaDário Trindade0Maria Cachide1Tânia Soares Martins2Sandra Guedes3Ilka M. Rosa4Odete A.B. da Cruz e Silva5Ana Gabriela Henriques6Neuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, PortugalNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, PortugalNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, PortugalNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, PortugalNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, PortugalNeuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, PortugalCorresponding author at: Neuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.; Neuroscience and Signaling Group, Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, PortugalObjective: Clusterin is involved in a variety of physiological processes, including proteostasis. Several clusterin polymorphisms were associated with an increased risk of developing Alzheimer’s disease, the world-leading cause of dementia. Herein, the effect of a clusterin polymorphism, aging and dementia in the levels of clusterin in human plasma were analysed in a primary care-based cohort, and the association of this chaperone with fibrillar structures discussed. Methods: 64 individuals with dementia (CDR≥1) and 64 age- and sex-matched Controls from a Portuguese cohort were genotyped for CLU rs1136000 polymorphism, and the plasma levels of clusterin and fibrils were assessed. Results: An increased prevalence of the CC genotype was observed for the dementia group, although no significant robustness was achieved. CLU rs11136000 SNP did not significantly change plasma clusterin levels in demented individuals. Instead, clusterin levels decreased with aging and even more in individuals with dementia. Importantly, plasma clusterin levels correlated with the presence of fibrillar structures in Control individuals, but not in those with dementia. Conclusion: This study reveals a significant decrease in plasma clusterin in demented individuals with aging, which related to altered clusterin-fibrils dynamics. Potentially, plasma clusterin and its association with fibrillar structures can be used to monitor dementia progression along aging.http://www.sciencedirect.com/science/article/pii/S2589958923000178ClusterinAgingFibrilsDementiaAlzheimer’s disease |
| spellingShingle | Dário Trindade Maria Cachide Tânia Soares Martins Sandra Guedes Ilka M. Rosa Odete A.B. da Cruz e Silva Ana Gabriela Henriques Monitoring clusterin and fibrillar structures in aging and dementia Aging Brain Clusterin Aging Fibrils Dementia Alzheimer’s disease |
| title | Monitoring clusterin and fibrillar structures in aging and dementia |
| title_full | Monitoring clusterin and fibrillar structures in aging and dementia |
| title_fullStr | Monitoring clusterin and fibrillar structures in aging and dementia |
| title_full_unstemmed | Monitoring clusterin and fibrillar structures in aging and dementia |
| title_short | Monitoring clusterin and fibrillar structures in aging and dementia |
| title_sort | monitoring clusterin and fibrillar structures in aging and dementia |
| topic | Clusterin Aging Fibrils Dementia Alzheimer’s disease |
| url | http://www.sciencedirect.com/science/article/pii/S2589958923000178 |
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