Salt Cocrystal of Diclofenac Sodium-L-Proline: Structural, Pseudopolymorphism, and Pharmaceutics Performance Study

Salt Cocrystal of Diclofenac Sodium-L-Proline: Structural, Pseudopolymorphism, and Pharmaceutics Performance Study

Previously, we have reported on a zwitterionic cocrystal of diclofenac acid and L-proline. However, the solubility of this multicomponent crystal was still lower than that of diclofenac sodium salt. Therefore, this study aimed to observe whether a multicomponent crystal could be produced from diclof...

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Bibliographic Details
Main Authors: Ilma Nugrahani, Rizka A. Kumalasari, Winni N. Auli, Ayano Horikawa, Hidehiro Uekusa
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
diclofenac sodium
L-proline
salt cocrystal
multicomponent crystal
monohydrate
tetrahydrate
Online Access:https://www.mdpi.com/1999-4923/12/7/690

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