SAMHD1 … and Viral Ways around It
The SAM and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase that plays a crucial role for a variety of different cellular functions. Besides balancing intracellular dNTP concentrations, facilitating DNA damage repair, and dampening excessive immune responses, SAMHD1 has been sh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/3/395 |
| _version_ | 1797416217197150208 |
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| author | Janina Deutschmann Thomas Gramberg |
| author_facet | Janina Deutschmann Thomas Gramberg |
| author_sort | Janina Deutschmann |
| collection | DOAJ |
| description | The SAM and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase that plays a crucial role for a variety of different cellular functions. Besides balancing intracellular dNTP concentrations, facilitating DNA damage repair, and dampening excessive immune responses, SAMHD1 has been shown to act as a major restriction factor against various virus species. In addition to its well-described activity against retroviruses such as HIV-1, SAMHD1 has been identified to reduce the infectivity of different DNA viruses such as the herpesviruses CMV and EBV, the poxvirus VACV, or the hepadnavirus HBV. While some viruses are efficiently restricted by SAMHD1, others have developed evasion mechanisms that antagonize the antiviral activity of SAMHD1. Within this review, we summarize the different cellular functions of SAMHD1 and highlight the countermeasures viruses have evolved to neutralize the restriction factor SAMHD1. |
| first_indexed | 2024-03-09T06:00:16Z |
| format | Article |
| id | doaj.art-8c04285eaedd403abcfd7b11547e795b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T06:00:16Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-8c04285eaedd403abcfd7b11547e795b2023-12-03T12:09:57ZengMDPI AGViruses1999-49152021-03-0113339510.3390/v13030395SAMHD1 … and Viral Ways around ItJanina Deutschmann0Thomas Gramberg1Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, GermanyInstitute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, GermanyThe SAM and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase that plays a crucial role for a variety of different cellular functions. Besides balancing intracellular dNTP concentrations, facilitating DNA damage repair, and dampening excessive immune responses, SAMHD1 has been shown to act as a major restriction factor against various virus species. In addition to its well-described activity against retroviruses such as HIV-1, SAMHD1 has been identified to reduce the infectivity of different DNA viruses such as the herpesviruses CMV and EBV, the poxvirus VACV, or the hepadnavirus HBV. While some viruses are efficiently restricted by SAMHD1, others have developed evasion mechanisms that antagonize the antiviral activity of SAMHD1. Within this review, we summarize the different cellular functions of SAMHD1 and highlight the countermeasures viruses have evolved to neutralize the restriction factor SAMHD1.https://www.mdpi.com/1999-4915/13/3/395SAMHD1restriction factorviral antagonismHIVherpesvirusesviral kinases |
| spellingShingle | Janina Deutschmann Thomas Gramberg SAMHD1 … and Viral Ways around It Viruses SAMHD1 restriction factor viral antagonism HIV herpesviruses viral kinases |
| title | SAMHD1 … and Viral Ways around It |
| title_full | SAMHD1 … and Viral Ways around It |
| title_fullStr | SAMHD1 … and Viral Ways around It |
| title_full_unstemmed | SAMHD1 … and Viral Ways around It |
| title_short | SAMHD1 … and Viral Ways around It |
| title_sort | samhd1 and viral ways around it |
| topic | SAMHD1 restriction factor viral antagonism HIV herpesviruses viral kinases |
| url | https://www.mdpi.com/1999-4915/13/3/395 |
| work_keys_str_mv | AT janinadeutschmann samhd1andviralwaysaroundit AT thomasgramberg samhd1andviralwaysaroundit |