Advances for pharmacological activities of Polygonum cuspidatum - A review
AbstractContext Polygonum cuspidatum Sieb. et Zucc (Polygonaceae), the root of which is included in the Chinese Pharmcopoeia under the name ‘Huzhang', has a long history as a medicinal plant and vegetable. Polygonum cuspidatum has been used in traditional Chinese medicine for the treatment of i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Pharmaceutical Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13880209.2022.2158349 |
| _version_ | 1797234845425860608 |
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| author | Jia Ke Meng-Ting Li Shuyang Xu Jianpeng Ma Ming-Yuan Liu Yan Han |
| author_facet | Jia Ke Meng-Ting Li Shuyang Xu Jianpeng Ma Ming-Yuan Liu Yan Han |
| author_sort | Jia Ke |
| collection | DOAJ |
| description | AbstractContext Polygonum cuspidatum Sieb. et Zucc (Polygonaceae), the root of which is included in the Chinese Pharmcopoeia under the name ‘Huzhang', has a long history as a medicinal plant and vegetable. Polygonum cuspidatum has been used in traditional Chinese medicine for the treatment of inflammation, hyperlipemia, etc.Objective This article reviews the pharmacological action and the clinical applications of Polygonum cuspidatum and its extracts, whether in vivo or in vitro. We also summarized the main phytochemical constituents and pharmacokinetics of Polygonum cuspidatum and its extracts.Methods The data were retrieved from major medical databases, such as CNKI, PubMed, and SinoMed, from 2014 to 2022. Polygonum cuspidatum, pharmacology, toxicity, clinical application, and pharmacokinetics were used as keywords.Results The rhizomes, leaves, and flowers of Polygonum cuspidatum have different phytochemical constituents. The plant contains flavonoids, anthraquinones, and stilbenes. Polygonum cuspidatum and the extracts have anti-inflammatory, antioxidation, anticancer, heart protection, and other pharmacological effects. It is used in the clinics to treat dizziness, headaches, traumatic injuries, and water and fire burns.Conclusions Polygonum cuspidatum has the potential to treat many diseases, such as arthritis, ulcerative colitis, asthma, and cardiac hypertrophy. It has a broad range of medicinal applications, but mainly focused on root medication; its aerial parts should receive more attention. Pharmacokinetics also need to be further investigated. |
| first_indexed | 2024-03-09T00:09:21Z |
| format | Article |
| id | doaj.art-8c04353ee5944318bb378d62b05a843d |
| institution | Directory Open Access Journal |
| issn | 1388-0209 1744-5116 |
| language | English |
| last_indexed | 2024-04-24T16:38:32Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Pharmaceutical Biology |
| spelling | doaj.art-8c04353ee5944318bb378d62b05a843d2024-03-29T11:10:26ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162023-12-0161117718810.1080/13880209.2022.2158349Advances for pharmacological activities of Polygonum cuspidatum - A reviewJia Ke0Meng-Ting Li1Shuyang Xu2Jianpeng Ma3Ming-Yuan Liu4Yan Han5Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaMonteverde Academy Shanghai, Shanghai, ChinaMultiscale Research Institute of Complex Systems, Fudan University, Shanghai, ChinaDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaAbstractContext Polygonum cuspidatum Sieb. et Zucc (Polygonaceae), the root of which is included in the Chinese Pharmcopoeia under the name ‘Huzhang', has a long history as a medicinal plant and vegetable. Polygonum cuspidatum has been used in traditional Chinese medicine for the treatment of inflammation, hyperlipemia, etc.Objective This article reviews the pharmacological action and the clinical applications of Polygonum cuspidatum and its extracts, whether in vivo or in vitro. We also summarized the main phytochemical constituents and pharmacokinetics of Polygonum cuspidatum and its extracts.Methods The data were retrieved from major medical databases, such as CNKI, PubMed, and SinoMed, from 2014 to 2022. Polygonum cuspidatum, pharmacology, toxicity, clinical application, and pharmacokinetics were used as keywords.Results The rhizomes, leaves, and flowers of Polygonum cuspidatum have different phytochemical constituents. The plant contains flavonoids, anthraquinones, and stilbenes. Polygonum cuspidatum and the extracts have anti-inflammatory, antioxidation, anticancer, heart protection, and other pharmacological effects. It is used in the clinics to treat dizziness, headaches, traumatic injuries, and water and fire burns.Conclusions Polygonum cuspidatum has the potential to treat many diseases, such as arthritis, ulcerative colitis, asthma, and cardiac hypertrophy. It has a broad range of medicinal applications, but mainly focused on root medication; its aerial parts should receive more attention. Pharmacokinetics also need to be further investigated.https://www.tandfonline.com/doi/10.1080/13880209.2022.2158349Huzhanganti-inflammatoryanticancerheart protectionpharmacokineticsChinese herb |
| spellingShingle | Jia Ke Meng-Ting Li Shuyang Xu Jianpeng Ma Ming-Yuan Liu Yan Han Advances for pharmacological activities of Polygonum cuspidatum - A review Pharmaceutical Biology Huzhang anti-inflammatory anticancer heart protection pharmacokinetics Chinese herb |
| title | Advances for pharmacological activities of Polygonum cuspidatum - A review |
| title_full | Advances for pharmacological activities of Polygonum cuspidatum - A review |
| title_fullStr | Advances for pharmacological activities of Polygonum cuspidatum - A review |
| title_full_unstemmed | Advances for pharmacological activities of Polygonum cuspidatum - A review |
| title_short | Advances for pharmacological activities of Polygonum cuspidatum - A review |
| title_sort | advances for pharmacological activities of polygonum cuspidatum a review |
| topic | Huzhang anti-inflammatory anticancer heart protection pharmacokinetics Chinese herb |
| url | https://www.tandfonline.com/doi/10.1080/13880209.2022.2158349 |
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