<i>Helicobacter pylori</i>-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction
Gastric cancer is ranked fifth in cancer list and has the third highest mortality rate. <i>Helicobacter pylori</i> is a class I carcinogen and a predominant etiological factor of gastric cancer. <i>H. pylori</i> infection may induce carcinogenesis via epigenetic alterations i...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/8/1/23 |
| _version_ | 1818039797118140416 |
|---|---|
| author | Jibran Sualeh Muhammad Mohamed Ahmed Eladl Ghalia Khoder |
| author_facet | Jibran Sualeh Muhammad Mohamed Ahmed Eladl Ghalia Khoder |
| author_sort | Jibran Sualeh Muhammad |
| collection | DOAJ |
| description | Gastric cancer is ranked fifth in cancer list and has the third highest mortality rate. <i>Helicobacter pylori</i> is a class I carcinogen and a predominant etiological factor of gastric cancer. <i>H. pylori</i> infection may induce carcinogenesis via epigenetic alterations in the promoter region of various genes. <i>H. pylori</i> is known to induce hypermethylation-silencing of several tumor suppressor genes in <i>H. pylori</i>-infected cancerous and <i>H. pylori</i>-infected non-cancerous gastric mucosae. This article presents a review of the published literature mainly from the last year 15 years. The topic focuses on <i>H. pylori</i>-induced DNA methylation linked to gastric cancer development. The authors have used MeSH terms “<i>Helicobacter pylori</i>„ with “epigenetic,„ “DNA methylation,„ in combination with “gastric inflammation„, gastritis„ and “gastric cancer„ to search SCOPUS, PubMed, Ovid, and Web of Science databases. The success of epigenetic drugs such as de-methylating agents in the treatment of certain cancers has led towards new prospects that similar approaches could also be applied against gastric cancer. However, it is very important to understand the role of all the genes that have already been linked to <i>H. pylori</i>-induced DNA methylation in order to in order to evaluate the potential benefits of epigenetic drugs. |
| first_indexed | 2024-12-10T08:04:20Z |
| format | Article |
| id | doaj.art-8c0440ff8d1d4573ac833532f5571a6b |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-12-10T08:04:20Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-8c0440ff8d1d4573ac833532f5571a6b2022-12-22T01:56:43ZengMDPI AGPathogens2076-08172019-02-01812310.3390/pathogens8010023pathogens8010023<i>Helicobacter pylori</i>-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future DirectionJibran Sualeh Muhammad0Mohamed Ahmed Eladl1Ghalia Khoder2Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAEDepartment of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAEDepartment of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, UAEGastric cancer is ranked fifth in cancer list and has the third highest mortality rate. <i>Helicobacter pylori</i> is a class I carcinogen and a predominant etiological factor of gastric cancer. <i>H. pylori</i> infection may induce carcinogenesis via epigenetic alterations in the promoter region of various genes. <i>H. pylori</i> is known to induce hypermethylation-silencing of several tumor suppressor genes in <i>H. pylori</i>-infected cancerous and <i>H. pylori</i>-infected non-cancerous gastric mucosae. This article presents a review of the published literature mainly from the last year 15 years. The topic focuses on <i>H. pylori</i>-induced DNA methylation linked to gastric cancer development. The authors have used MeSH terms “<i>Helicobacter pylori</i>„ with “epigenetic,„ “DNA methylation,„ in combination with “gastric inflammation„, gastritis„ and “gastric cancer„ to search SCOPUS, PubMed, Ovid, and Web of Science databases. The success of epigenetic drugs such as de-methylating agents in the treatment of certain cancers has led towards new prospects that similar approaches could also be applied against gastric cancer. However, it is very important to understand the role of all the genes that have already been linked to <i>H. pylori</i>-induced DNA methylation in order to in order to evaluate the potential benefits of epigenetic drugs.https://www.mdpi.com/2076-0817/8/1/23<i>Helicobacter pylori</i>epigeneticsDNA methylationgastric cancer |
| spellingShingle | Jibran Sualeh Muhammad Mohamed Ahmed Eladl Ghalia Khoder <i>Helicobacter pylori</i>-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction Pathogens <i>Helicobacter pylori</i> epigenetics DNA methylation gastric cancer |
| title | <i>Helicobacter pylori</i>-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction |
| title_full | <i>Helicobacter pylori</i>-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction |
| title_fullStr | <i>Helicobacter pylori</i>-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction |
| title_full_unstemmed | <i>Helicobacter pylori</i>-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction |
| title_short | <i>Helicobacter pylori</i>-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction |
| title_sort | i helicobacter pylori i induced dna methylation as an epigenetic modulator of gastric cancer recent outcomes and future direction |
| topic | <i>Helicobacter pylori</i> epigenetics DNA methylation gastric cancer |
| url | https://www.mdpi.com/2076-0817/8/1/23 |
| work_keys_str_mv | AT jibransualehmuhammad ihelicobacterpyloriiinduceddnamethylationasanepigeneticmodulatorofgastriccancerrecentoutcomesandfuturedirection AT mohamedahmedeladl ihelicobacterpyloriiinduceddnamethylationasanepigeneticmodulatorofgastriccancerrecentoutcomesandfuturedirection AT ghaliakhoder ihelicobacterpyloriiinduceddnamethylationasanepigeneticmodulatorofgastriccancerrecentoutcomesandfuturedirection |