Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis
Intrinsic cell death is mediated by interaction between pro-apoptotic and pro-survival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/11/4/1808/ |
| _version_ | 1811244405314551808 |
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| author | Gilles J. P. Rautureau Catherine L. Day Mark G. Hinds |
| author_facet | Gilles J. P. Rautureau Catherine L. Day Mark G. Hinds |
| author_sort | Gilles J. P. Rautureau |
| collection | DOAJ |
| description | Intrinsic cell death is mediated by interaction between pro-apoptotic and pro-survival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition. |
| first_indexed | 2024-04-12T14:23:19Z |
| format | Article |
| id | doaj.art-8c067c8d2568476d815a25ea1aa0e7b2 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T14:23:19Z |
| publishDate | 2010-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8c067c8d2568476d815a25ea1aa0e7b22022-12-22T03:29:30ZengMDPI AGInternational Journal of Molecular Sciences1422-00672010-04-011141808182410.3390/ijms11041808Intrinsically Disordered Proteins in Bcl-2 Regulated ApoptosisGilles J. P. RautureauCatherine L. DayMark G. HindsIntrinsic cell death is mediated by interaction between pro-apoptotic and pro-survival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition.http://www.mdpi.com/1422-0067/11/4/1808/apoptosisBcl-2BH3-onlyintrinsically disordered proteinprotein structure |
| spellingShingle | Gilles J. P. Rautureau Catherine L. Day Mark G. Hinds Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis International Journal of Molecular Sciences apoptosis Bcl-2 BH3-only intrinsically disordered protein protein structure |
| title | Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis |
| title_full | Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis |
| title_fullStr | Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis |
| title_full_unstemmed | Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis |
| title_short | Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis |
| title_sort | intrinsically disordered proteins in bcl 2 regulated apoptosis |
| topic | apoptosis Bcl-2 BH3-only intrinsically disordered protein protein structure |
| url | http://www.mdpi.com/1422-0067/11/4/1808/ |
| work_keys_str_mv | AT gillesjprautureau intrinsicallydisorderedproteinsinbcl2regulatedapoptosis AT catherinelday intrinsicallydisorderedproteinsinbcl2regulatedapoptosis AT markghinds intrinsicallydisorderedproteinsinbcl2regulatedapoptosis |