Clinical application of oligodendrocyte precursor cells for cell-based therapy
Oligodendrocyte precursor cells (OPCs), which give rise to mature oligodendrocytes (OLs), play important roles in maintaining white matter function. Even during the adulthood period, OPCs comprise roughly 5% of all cells in the forebrain and retain a capability to become myelinated OLs. Recently, OP...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Brain Circulation |
| Subjects: | |
| Online Access: | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2016;volume=2;issue=3;spage=121;epage=125;aulast=Egawa |
| _version_ | 1819129730919563264 |
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| author | Naohiro Egawa Hajime Takase Lok Josephine Ryosuke Takahashi Ken Arai |
| author_facet | Naohiro Egawa Hajime Takase Lok Josephine Ryosuke Takahashi Ken Arai |
| author_sort | Naohiro Egawa |
| collection | DOAJ |
| description | Oligodendrocyte precursor cells (OPCs), which give rise to mature oligodendrocytes (OLs), play important roles in maintaining white matter function. Even during the adulthood period, OPCs comprise roughly 5% of all cells in the forebrain and retain a capability to become myelinated OLs. Recently, OPCs have been proposed as a novel source for cell-based therapy. For the purpose, OPCs can be obtained from embryonic stem cells, induced pluripotent stem cells, and directly converted cells derived from patients. Here, we will provide a brief review of the potential of using OPCs as a cell-based therapy for treating various neurological diseases. |
| first_indexed | 2024-12-22T08:48:22Z |
| format | Article |
| id | doaj.art-8c06d926673c4e8093b9131cb80a8498 |
| institution | Directory Open Access Journal |
| issn | 2455-4626 |
| language | English |
| last_indexed | 2024-12-22T08:48:22Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Brain Circulation |
| spelling | doaj.art-8c06d926673c4e8093b9131cb80a84982022-12-21T18:32:02ZengWolters Kluwer Medknow PublicationsBrain Circulation2455-46262016-01-012312112510.4103/2394-8108.192515Clinical application of oligodendrocyte precursor cells for cell-based therapyNaohiro EgawaHajime TakaseLok JosephineRyosuke TakahashiKen AraiOligodendrocyte precursor cells (OPCs), which give rise to mature oligodendrocytes (OLs), play important roles in maintaining white matter function. Even during the adulthood period, OPCs comprise roughly 5% of all cells in the forebrain and retain a capability to become myelinated OLs. Recently, OPCs have been proposed as a novel source for cell-based therapy. For the purpose, OPCs can be obtained from embryonic stem cells, induced pluripotent stem cells, and directly converted cells derived from patients. Here, we will provide a brief review of the potential of using OPCs as a cell-based therapy for treating various neurological diseases.http://www.braincirculation.org/article.asp?issn=2394-8108;year=2016;volume=2;issue=3;spage=121;epage=125;aulast=EgawaCell transplantationoligodendrocyte precursor cellsstem cell therapy |
| spellingShingle | Naohiro Egawa Hajime Takase Lok Josephine Ryosuke Takahashi Ken Arai Clinical application of oligodendrocyte precursor cells for cell-based therapy Brain Circulation Cell transplantation oligodendrocyte precursor cells stem cell therapy |
| title | Clinical application of oligodendrocyte precursor cells for cell-based therapy |
| title_full | Clinical application of oligodendrocyte precursor cells for cell-based therapy |
| title_fullStr | Clinical application of oligodendrocyte precursor cells for cell-based therapy |
| title_full_unstemmed | Clinical application of oligodendrocyte precursor cells for cell-based therapy |
| title_short | Clinical application of oligodendrocyte precursor cells for cell-based therapy |
| title_sort | clinical application of oligodendrocyte precursor cells for cell based therapy |
| topic | Cell transplantation oligodendrocyte precursor cells stem cell therapy |
| url | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2016;volume=2;issue=3;spage=121;epage=125;aulast=Egawa |
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