Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis
Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal gluco...
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/15/3251 |
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| author | Juan J. Gagliardino Martin R. Salazar Walter G. Espeche Paula E. Tolosa Chapasian Daniela Gomez Garizoain Ricardo D. Olano Rodolfo N. Stavile Eduardo Balbín Camilo Martinez Betty C. Leiva Sisnieguez Carlos E. Leiva Sisnieguez Horacio A. Carbajal |
| author_facet | Juan J. Gagliardino Martin R. Salazar Walter G. Espeche Paula E. Tolosa Chapasian Daniela Gomez Garizoain Ricardo D. Olano Rodolfo N. Stavile Eduardo Balbín Camilo Martinez Betty C. Leiva Sisnieguez Carlos E. Leiva Sisnieguez Horacio A. Carbajal |
| author_sort | Juan J. Gagliardino |
| collection | DOAJ |
| description | Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs. |
| first_indexed | 2024-03-10T09:14:11Z |
| format | Article |
| id | doaj.art-8c0751f9c18b49f28a1b160c62f4f8f1 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:14:11Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8c0751f9c18b49f28a1b160c62f4f8f12023-11-22T05:48:01ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011015325110.3390/jcm10153251Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible PathogenesisJuan J. Gagliardino0Martin R. Salazar1Walter G. Espeche2Paula E. Tolosa Chapasian3Daniela Gomez Garizoain4Ricardo D. Olano5Rodolfo N. Stavile6Eduardo Balbín7Camilo Martinez8Betty C. Leiva Sisnieguez9Carlos E. Leiva Sisnieguez10Horacio A. Carbajal11CENEXA, Centro de Endocrinología Experimental y Aplicada (UNLP-CONICET-CEAS CICPBA), Facultad de Ciencias Médicas UNLP, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaCENEXA, Centro de Endocrinología Experimental y Aplicada (UNLP-CONICET-CEAS CICPBA), Facultad de Ciencias Médicas UNLP, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaUnidad de Enfermedades Cardiometabólicas, Hospital General San Martín, La Plata 1900, Buenos Aires, ArgentinaAims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs.https://www.mdpi.com/2077-0383/10/15/3251pulse wave velocityOGTTprediabetesTG/HDL ratiodyslipidemiaarterial stiffness |
| spellingShingle | Juan J. Gagliardino Martin R. Salazar Walter G. Espeche Paula E. Tolosa Chapasian Daniela Gomez Garizoain Ricardo D. Olano Rodolfo N. Stavile Eduardo Balbín Camilo Martinez Betty C. Leiva Sisnieguez Carlos E. Leiva Sisnieguez Horacio A. Carbajal Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis Journal of Clinical Medicine pulse wave velocity OGTT prediabetes TG/HDL ratio dyslipidemia arterial stiffness |
| title | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
| title_full | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
| title_fullStr | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
| title_full_unstemmed | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
| title_short | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
| title_sort | arterial stiffness its relation with prediabetes and metabolic syndrome and possible pathogenesis |
| topic | pulse wave velocity OGTT prediabetes TG/HDL ratio dyslipidemia arterial stiffness |
| url | https://www.mdpi.com/2077-0383/10/15/3251 |
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