Disability progression among leprosy patients released from treatment: a survival analysis
Abstract Background Leprosy can be cured, but physical disability (PD) as a result of the infection can progress in the post-release from treatment phase. This study evaluated the likelihood of, and factors associated with, the progression of the PD grade post-release from treatment among leprosy pa...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Infectious Diseases of Poverty |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40249-020-00669-4 |
| _version_ | 1818290119396818944 |
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| author | Aleksandra Rosendo dos Santos Pãmela Rodrigues de Souza Silva Peter Steinmann Eliane Ignotti |
| author_facet | Aleksandra Rosendo dos Santos Pãmela Rodrigues de Souza Silva Peter Steinmann Eliane Ignotti |
| author_sort | Aleksandra Rosendo dos Santos |
| collection | DOAJ |
| description | Abstract Background Leprosy can be cured, but physical disability (PD) as a result of the infection can progress in the post-release from treatment phase. This study evaluated the likelihood of, and factors associated with, the progression of the PD grade post-release from treatment among leprosy patients treated in Cáceres-MT, Brazil in the period 2000 to 2017. Methods A retrospective cohort study and survival analysis were performed in the hyperendemic municipality of Cáceres in the state of Mato Grosso. The study population consisted of newly diagnosed leprosy patients released from treatment between January 1, 2000 and December 31, 2017. The main outcome was the progression of the PD grade with regard to probability and time; and the evaluated covariates included clinical, operational and demographic variables. The Cox proportional risk model was used to estimate the risk ratio (Hazard Ratios) of the covariates. Both an univariate and a multivariate analysis were implemented, with 95% confidence intervals. Results The mean time for progression of the PD grade was 162 months for PB and 151 months for MB leprosy patients. The survival curve showed that 15 years after the release from treatment, the probability of PD grade progression was 35%, with no difference between PB and MB or age groups. Leprosy reactions and registered medical complaints of any kind during treatment were identified as risk factors with Hazard Ratios of 1.6 and 1.8 respectively. Conclusions People released from treatment as cured of leprosy are susceptible to worsening of the PD, especially those who have had complications during multi-drug therapy treatment. This indicates that leprosy patients should be periodically monitored, even after the successful completion of multidrug therapy. |
| first_indexed | 2024-12-13T02:23:06Z |
| format | Article |
| id | doaj.art-8c07f6bb4ed648b89c70f62281d36b76 |
| institution | Directory Open Access Journal |
| issn | 2049-9957 |
| language | English |
| last_indexed | 2024-12-13T02:23:06Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Diseases of Poverty |
| spelling | doaj.art-8c07f6bb4ed648b89c70f62281d36b762022-12-22T00:02:43ZengBMCInfectious Diseases of Poverty2049-99572020-05-01911710.1186/s40249-020-00669-4Disability progression among leprosy patients released from treatment: a survival analysisAleksandra Rosendo dos Santos0Pãmela Rodrigues de Souza Silva1Peter Steinmann2Eliane Ignotti3Health Sciences Graduation Program, Federal University of Mato Grosso (UFMT)Faculty of Nursing, Federal University of Mato Grosso (UFMT)Swiss Tropical and Public Health Institute (Swiss TPH)Health Sciences Graduation Program, Federal University of Mato Grosso (UFMT)Abstract Background Leprosy can be cured, but physical disability (PD) as a result of the infection can progress in the post-release from treatment phase. This study evaluated the likelihood of, and factors associated with, the progression of the PD grade post-release from treatment among leprosy patients treated in Cáceres-MT, Brazil in the period 2000 to 2017. Methods A retrospective cohort study and survival analysis were performed in the hyperendemic municipality of Cáceres in the state of Mato Grosso. The study population consisted of newly diagnosed leprosy patients released from treatment between January 1, 2000 and December 31, 2017. The main outcome was the progression of the PD grade with regard to probability and time; and the evaluated covariates included clinical, operational and demographic variables. The Cox proportional risk model was used to estimate the risk ratio (Hazard Ratios) of the covariates. Both an univariate and a multivariate analysis were implemented, with 95% confidence intervals. Results The mean time for progression of the PD grade was 162 months for PB and 151 months for MB leprosy patients. The survival curve showed that 15 years after the release from treatment, the probability of PD grade progression was 35%, with no difference between PB and MB or age groups. Leprosy reactions and registered medical complaints of any kind during treatment were identified as risk factors with Hazard Ratios of 1.6 and 1.8 respectively. Conclusions People released from treatment as cured of leprosy are susceptible to worsening of the PD, especially those who have had complications during multi-drug therapy treatment. This indicates that leprosy patients should be periodically monitored, even after the successful completion of multidrug therapy.http://link.springer.com/article/10.1186/s40249-020-00669-4LeprosyPhysical disabilityCureProgressionSurvival |
| spellingShingle | Aleksandra Rosendo dos Santos Pãmela Rodrigues de Souza Silva Peter Steinmann Eliane Ignotti Disability progression among leprosy patients released from treatment: a survival analysis Infectious Diseases of Poverty Leprosy Physical disability Cure Progression Survival |
| title | Disability progression among leprosy patients released from treatment: a survival analysis |
| title_full | Disability progression among leprosy patients released from treatment: a survival analysis |
| title_fullStr | Disability progression among leprosy patients released from treatment: a survival analysis |
| title_full_unstemmed | Disability progression among leprosy patients released from treatment: a survival analysis |
| title_short | Disability progression among leprosy patients released from treatment: a survival analysis |
| title_sort | disability progression among leprosy patients released from treatment a survival analysis |
| topic | Leprosy Physical disability Cure Progression Survival |
| url | http://link.springer.com/article/10.1186/s40249-020-00669-4 |
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