Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern Medicine
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract, which has become a serious threat to human health worldwide. This article exhaustively reviews colorectal cancer’s incidence and relevance, carcinogenesis molecular pathways, up-to-date treatment opportunities, prophy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/4/2032 |
| _version_ | 1797298021325602816 |
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| author | Monika Berbecka Maciej Berbecki Anna Maria Gliwa Monika Szewc Robert Sitarz |
| author_facet | Monika Berbecka Maciej Berbecki Anna Maria Gliwa Monika Szewc Robert Sitarz |
| author_sort | Monika Berbecka |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract, which has become a serious threat to human health worldwide. This article exhaustively reviews colorectal cancer’s incidence and relevance, carcinogenesis molecular pathways, up-to-date treatment opportunities, prophylaxis, and screening program achievements, with attention paid to its regional variations and changes over time. This paper provides a concise overview of known CRC risk factors, including familial, hereditary, and environmental lifestyle-related risk factors. The authors take a closer look into CRC’s molecular genetic pathways and the role of specific enzymes involved in carcinogenesis. Moreover, the role of the general practitioner and multidisciplinary approach in CRC treatment is summarized and highlighted based on recent recommendations and experience. This article gives a clear understanding and review of the gains and challenges of modern medicine towards CRC. The authors believe that understanding the current patterns of CRC and its revolution is imperative to the prospects of reducing its burden through cancer prevention and cancer-adjusted treatment. |
| first_indexed | 2024-03-07T22:29:50Z |
| format | Article |
| id | doaj.art-8c09439525c942d38e6bad28fccadf39 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-07T22:29:50Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8c09439525c942d38e6bad28fccadf392024-02-23T15:19:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01254203210.3390/ijms25042032Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern MedicineMonika Berbecka0Maciej Berbecki1Anna Maria Gliwa2Monika Szewc3Robert Sitarz4Department of Human Anatomy, Medical University of Lublin, 20-950 Lublin, PolandGeneral Surgery Ward, Independent Health Center in Kraśnik, 23-200 Kraśnik, PolandDepartment of Human Anatomy, Medical University of Lublin, 20-950 Lublin, PolandDepartment of Human Anatomy, Medical University of Lublin, 20-950 Lublin, PolandDepartment of Human Anatomy, Medical University of Lublin, 20-950 Lublin, PolandColorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract, which has become a serious threat to human health worldwide. This article exhaustively reviews colorectal cancer’s incidence and relevance, carcinogenesis molecular pathways, up-to-date treatment opportunities, prophylaxis, and screening program achievements, with attention paid to its regional variations and changes over time. This paper provides a concise overview of known CRC risk factors, including familial, hereditary, and environmental lifestyle-related risk factors. The authors take a closer look into CRC’s molecular genetic pathways and the role of specific enzymes involved in carcinogenesis. Moreover, the role of the general practitioner and multidisciplinary approach in CRC treatment is summarized and highlighted based on recent recommendations and experience. This article gives a clear understanding and review of the gains and challenges of modern medicine towards CRC. The authors believe that understanding the current patterns of CRC and its revolution is imperative to the prospects of reducing its burden through cancer prevention and cancer-adjusted treatment.https://www.mdpi.com/1422-0067/25/4/2032colorectal cancerepidemiologyscreeningprophylaxisrisk factorsbiomarkers |
| spellingShingle | Monika Berbecka Maciej Berbecki Anna Maria Gliwa Monika Szewc Robert Sitarz Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern Medicine International Journal of Molecular Sciences colorectal cancer epidemiology screening prophylaxis risk factors biomarkers |
| title | Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern Medicine |
| title_full | Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern Medicine |
| title_fullStr | Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern Medicine |
| title_full_unstemmed | Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern Medicine |
| title_short | Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern Medicine |
| title_sort | managing colorectal cancer from ethology to interdisciplinary treatment the gains and challenges of modern medicine |
| topic | colorectal cancer epidemiology screening prophylaxis risk factors biomarkers |
| url | https://www.mdpi.com/1422-0067/25/4/2032 |
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