Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines
Vaccines represent the discovery of utmost importance for global health, due to both prophylactic action to prevent infections and therapeutic intervention in neoplastic diseases. Despite this, current vaccination strategies need to be refined to successfully generate robust protective antigen-speci...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01484/full |
| _version_ | 1828393213156655104 |
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| author | Laura Gornati Ivan Zanoni Ivan Zanoni Francesca Granucci |
| author_facet | Laura Gornati Ivan Zanoni Ivan Zanoni Francesca Granucci |
| author_sort | Laura Gornati |
| collection | DOAJ |
| description | Vaccines represent the discovery of utmost importance for global health, due to both prophylactic action to prevent infections and therapeutic intervention in neoplastic diseases. Despite this, current vaccination strategies need to be refined to successfully generate robust protective antigen-specific memory immune responses. To address this issue, one possibility is to exploit the high efficiency of dendritic cells (DCs) as antigen-presenting cells for T cell priming. DCs functional plasticity allows shaping the outcome of immune responses to achieve the required type of immunity. Therefore, the choice of adjuvants to guide and sustain DCs maturation, the design of multifaceted vehicles, and the choice of surface molecules to specifically target DCs represent the key issues currently explored in both preclinical and clinical settings. Here, we review advances in DCs-based vaccination approaches, which exploit direct in vivo DCs targeting and activation options. We also discuss the recent findings for efficient antitumor DCs-based vaccinations and combination strategies to reduce the immune tolerance promoted by the tumor microenvironment. |
| first_indexed | 2024-12-10T07:35:20Z |
| format | Article |
| id | doaj.art-8c09a5e9effd4334a341854d63633ee5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T07:35:20Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8c09a5e9effd4334a341854d63633ee52022-12-22T01:57:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-06-01910.3389/fimmu.2018.01484366092Dendritic Cells in the Cross Hair for the Generation of Tailored VaccinesLaura Gornati0Ivan Zanoni1Ivan Zanoni2Francesca Granucci3Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, ItalyDivision of Gastroenterology, Harvard Medical School, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, ItalyVaccines represent the discovery of utmost importance for global health, due to both prophylactic action to prevent infections and therapeutic intervention in neoplastic diseases. Despite this, current vaccination strategies need to be refined to successfully generate robust protective antigen-specific memory immune responses. To address this issue, one possibility is to exploit the high efficiency of dendritic cells (DCs) as antigen-presenting cells for T cell priming. DCs functional plasticity allows shaping the outcome of immune responses to achieve the required type of immunity. Therefore, the choice of adjuvants to guide and sustain DCs maturation, the design of multifaceted vehicles, and the choice of surface molecules to specifically target DCs represent the key issues currently explored in both preclinical and clinical settings. Here, we review advances in DCs-based vaccination approaches, which exploit direct in vivo DCs targeting and activation options. We also discuss the recent findings for efficient antitumor DCs-based vaccinations and combination strategies to reduce the immune tolerance promoted by the tumor microenvironment.https://www.frontiersin.org/article/10.3389/fimmu.2018.01484/fulldendritic cellsvaccinationpattern recognition receptorsantigen deliveryadjuvants |
| spellingShingle | Laura Gornati Ivan Zanoni Ivan Zanoni Francesca Granucci Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines Frontiers in Immunology dendritic cells vaccination pattern recognition receptors antigen delivery adjuvants |
| title | Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines |
| title_full | Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines |
| title_fullStr | Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines |
| title_full_unstemmed | Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines |
| title_short | Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines |
| title_sort | dendritic cells in the cross hair for the generation of tailored vaccines |
| topic | dendritic cells vaccination pattern recognition receptors antigen delivery adjuvants |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01484/full |
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