Dissociable roles for the striatal cholinergic system in different flexibility contexts
The production of behavioural flexibility requires the coordination and integration of information from across the brain, by the dorsal striatum. In particular, the striatal cholinergic system is thought to be important for the modulation of striatal activity. Research from animal literature has sho...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242122000197 |
| _version_ | 1817967991023730688 |
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| author | Brendan Williams Anastasia Christakou |
| author_facet | Brendan Williams Anastasia Christakou |
| author_sort | Brendan Williams |
| collection | DOAJ |
| description | The production of behavioural flexibility requires the coordination and integration of information from across the brain, by the dorsal striatum. In particular, the striatal cholinergic system is thought to be important for the modulation of striatal activity. Research from animal literature has shown that chemical inactivation of the dorsal striatum leads to impairments in reversal learning. Furthermore, proton magnetic resonance spectroscopy work has shown that the striatal cholinergic system is also important for reversal learning in humans. Here, we aim to assess whether the state of the dorsal striatal cholinergic system at rest is related to serial reversal learning in humans. We provide preliminary results showing that variability in choline in the dorsal striatum is significantly related to both the number of perseverative and regressive errors that participants make, and their rate of learning from positive and negative prediction errors. These findings, in line with previous work, suggest the resting state of dorsal striatal cholinergic system has important implications for producing flexible behaviour. However, these results also suggest the system may have heterogeneous functionality across different types of tasks measuring behavioural flexibility. These findings provide a starting point for further interrogation into understanding the functional role of the striatal cholinergic system in flexibility. |
| first_indexed | 2024-04-13T20:03:09Z |
| format | Article |
| id | doaj.art-8c0bf5a868da4c5ba5057ddb5d2e6cfc |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-04-13T20:03:09Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-8c0bf5a868da4c5ba5057ddb5d2e6cfc2022-12-22T02:32:09ZengElsevierIBRO Neuroscience Reports2667-24212022-06-0112260270Dissociable roles for the striatal cholinergic system in different flexibility contextsBrendan Williams0Anastasia Christakou1Centre for Integrative Neuroscience and Neurodynamics, University of Reading, UK; School of Psychology and Clinical Language Sciences, University of Reading, UK; Correspondence to: Centre for Integrative Neuroscience and Neurodynamics, Harry Pitt Building, University of Reading, Reading, Berkshire, UK.Centre for Integrative Neuroscience and Neurodynamics, University of Reading, UK; School of Psychology and Clinical Language Sciences, University of Reading, UKThe production of behavioural flexibility requires the coordination and integration of information from across the brain, by the dorsal striatum. In particular, the striatal cholinergic system is thought to be important for the modulation of striatal activity. Research from animal literature has shown that chemical inactivation of the dorsal striatum leads to impairments in reversal learning. Furthermore, proton magnetic resonance spectroscopy work has shown that the striatal cholinergic system is also important for reversal learning in humans. Here, we aim to assess whether the state of the dorsal striatal cholinergic system at rest is related to serial reversal learning in humans. We provide preliminary results showing that variability in choline in the dorsal striatum is significantly related to both the number of perseverative and regressive errors that participants make, and their rate of learning from positive and negative prediction errors. These findings, in line with previous work, suggest the resting state of dorsal striatal cholinergic system has important implications for producing flexible behaviour. However, these results also suggest the system may have heterogeneous functionality across different types of tasks measuring behavioural flexibility. These findings provide a starting point for further interrogation into understanding the functional role of the striatal cholinergic system in flexibility.http://www.sciencedirect.com/science/article/pii/S2667242122000197CholineBehavioural flexibilityCognitive flexibilityMagnetic resonance spectroscopyReversal learningStriatum |
| spellingShingle | Brendan Williams Anastasia Christakou Dissociable roles for the striatal cholinergic system in different flexibility contexts IBRO Neuroscience Reports Choline Behavioural flexibility Cognitive flexibility Magnetic resonance spectroscopy Reversal learning Striatum |
| title | Dissociable roles for the striatal cholinergic system in different flexibility contexts |
| title_full | Dissociable roles for the striatal cholinergic system in different flexibility contexts |
| title_fullStr | Dissociable roles for the striatal cholinergic system in different flexibility contexts |
| title_full_unstemmed | Dissociable roles for the striatal cholinergic system in different flexibility contexts |
| title_short | Dissociable roles for the striatal cholinergic system in different flexibility contexts |
| title_sort | dissociable roles for the striatal cholinergic system in different flexibility contexts |
| topic | Choline Behavioural flexibility Cognitive flexibility Magnetic resonance spectroscopy Reversal learning Striatum |
| url | http://www.sciencedirect.com/science/article/pii/S2667242122000197 |
| work_keys_str_mv | AT brendanwilliams dissociablerolesforthestriatalcholinergicsystemindifferentflexibilitycontexts AT anastasiachristakou dissociablerolesforthestriatalcholinergicsystemindifferentflexibilitycontexts |