Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma

Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma

Abstract Background The functions of the protein expressed in the nucleus and cytoplasm were different or opposite. The previous study found that oncogene Klf4 played a role of tumor suppressor in the nasopharyngeal cytoplasm. Cetuximab targeted epidermal growth factor receptor (EGFR) for the treatm...

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Bibliographic Details
Main Authors: Xiqing Li, Zunlan Zhao, Shijiang Yi, Lei Ma, Ming Li, Mingyue Liu, Yaping Zhang, Guangzhi Liu
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Translational Medicine
Subjects:
Klf4
Cetuximab
Drug-resistance
Prognosis
Nasopharyngeal carcinoma
Online Access:http://link.springer.com/article/10.1186/s12967-018-1561-0

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