Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
Aim: To investigate the effect of a macro-nutrient preload (Inzone Vitality) on blood glucose levels and pregnancy outcomes of gestational diabetes. The preload method involves the ingestion of a smaller amount of a macronutrient composition half an hour before regular meals. The hypothesis was that...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Journal of Clinical & Translational Endocrinology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214623716300047 |
| _version_ | 1819147771060420608 |
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| author | Li Li Jing Xu Wenyi Zhu Rong Fan Qian Bai Chen Huang Jun Liu Zhen Li Magnus Sederholm Gunnar Norstedt Jian Wang |
| author_facet | Li Li Jing Xu Wenyi Zhu Rong Fan Qian Bai Chen Huang Jun Liu Zhen Li Magnus Sederholm Gunnar Norstedt Jian Wang |
| author_sort | Li Li |
| collection | DOAJ |
| description | Aim: To investigate the effect of a macro-nutrient preload (Inzone Vitality) on blood glucose levels and pregnancy outcomes of gestational diabetes. The preload method involves the ingestion of a smaller amount of a macronutrient composition half an hour before regular meals. The hypothesis was that preload treatment will reduce postprandial glycemia in gestational diabetes.
Methods: Sixty-six diagnosed cases of gestational diabetes were randomly selected from gynecology and obstetrics outpatient clinic at Xinqiao Hospital in Chongqing. The patients were divided into an intervention group (33 cases) and a control group (33 cases), according to odd–even numbers of the random cases. The intervention group was treated with a macro-nutrient preload given 0.5 h before regular meals and the control group was given a comparative treatment consisting of a milk powder with similar energy content. The two groups were studied until delivery and the measured parameters included fasting blood glucose (FBG), 2-hour postprandial blood glucose (2h-PBG), delivery mode and neonatal birth weight.
Results: The two groups showed no differences in FBG or 2h-PBG before the nutritional intervention. FBG and 2h-PBG after intervention and before delivery were significantly lower in the intervention group, treated with the macro nutrient preload compared to the control group (P < 0.01). Changes in FBG and 2h-PBG before and after the intervention were investigated and the difference in the intervention group was significantly greater than corresponding values in the control group (P < 0.05, P < 0.01). The neonatal birth weight and delivery mode was not significantly different (P > 0.05).
Conclusion: A macro-nutrient composition, used as a preload, is effective in controlling FBG and PBG of gestational diabetes. |
| first_indexed | 2024-12-22T13:35:06Z |
| format | Article |
| id | doaj.art-8c0f2a66a10447d1ab6f82263c84ff44 |
| institution | Directory Open Access Journal |
| issn | 2214-6237 |
| language | English |
| last_indexed | 2024-12-22T13:35:06Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical & Translational Endocrinology |
| spelling | doaj.art-8c0f2a66a10447d1ab6f82263c84ff442022-12-21T18:24:05ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372016-09-015C364110.1016/j.jcte.2016.04.001Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetesLi Li0Jing Xu1Wenyi Zhu2Rong Fan3Qian Bai4Chen Huang5Jun Liu6Zhen Li7Magnus Sederholm8Gunnar Norstedt9Jian Wang10Department of Nutrition, Xinqiao Hospital, Chongqing 400037, ChinaDepartment of Endocrinology, Xinqiao Hospital, Chongqing 400037, ChinaDepartment of Nutrition, Xinqiao Hospital, Chongqing 400037, ChinaDepartment of Nutrition, Xinqiao Hospital, Chongqing 400037, ChinaDepartment of Nutrition, Xinqiao Hospital, Chongqing 400037, ChinaDepartment of Nutrition, Xinqiao Hospital, Chongqing 400037, ChinaDepartment of Nutrition, Xinqiao Hospital, Chongqing 400037, ChinaDepartment of Obstetrics and Gynecology, Xinqiao Hospital, Chongqing 400037, ChinaDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, SwedenDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, SwedenDepartment of Nutrition, Xinqiao Hospital, Chongqing 400037, ChinaAim: To investigate the effect of a macro-nutrient preload (Inzone Vitality) on blood glucose levels and pregnancy outcomes of gestational diabetes. The preload method involves the ingestion of a smaller amount of a macronutrient composition half an hour before regular meals. The hypothesis was that preload treatment will reduce postprandial glycemia in gestational diabetes. Methods: Sixty-six diagnosed cases of gestational diabetes were randomly selected from gynecology and obstetrics outpatient clinic at Xinqiao Hospital in Chongqing. The patients were divided into an intervention group (33 cases) and a control group (33 cases), according to odd–even numbers of the random cases. The intervention group was treated with a macro-nutrient preload given 0.5 h before regular meals and the control group was given a comparative treatment consisting of a milk powder with similar energy content. The two groups were studied until delivery and the measured parameters included fasting blood glucose (FBG), 2-hour postprandial blood glucose (2h-PBG), delivery mode and neonatal birth weight. Results: The two groups showed no differences in FBG or 2h-PBG before the nutritional intervention. FBG and 2h-PBG after intervention and before delivery were significantly lower in the intervention group, treated with the macro nutrient preload compared to the control group (P < 0.01). Changes in FBG and 2h-PBG before and after the intervention were investigated and the difference in the intervention group was significantly greater than corresponding values in the control group (P < 0.05, P < 0.01). The neonatal birth weight and delivery mode was not significantly different (P > 0.05). Conclusion: A macro-nutrient composition, used as a preload, is effective in controlling FBG and PBG of gestational diabetes.http://www.sciencedirect.com/science/article/pii/S2214623716300047Gestational diabetesPostprandial blood glucoseNutrition therapyPreload |
| spellingShingle | Li Li Jing Xu Wenyi Zhu Rong Fan Qian Bai Chen Huang Jun Liu Zhen Li Magnus Sederholm Gunnar Norstedt Jian Wang Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes Journal of Clinical & Translational Endocrinology Gestational diabetes Postprandial blood glucose Nutrition therapy Preload |
| title | Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes |
| title_full | Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes |
| title_fullStr | Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes |
| title_full_unstemmed | Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes |
| title_short | Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes |
| title_sort | effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes |
| topic | Gestational diabetes Postprandial blood glucose Nutrition therapy Preload |
| url | http://www.sciencedirect.com/science/article/pii/S2214623716300047 |
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