Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid Arthritis
Adipokines were shown to exert crucial roles in rheumatic diseases. This study aimed to assess the role of chemerin, apelin, vaspin, and omentin adipokines and their genetic variants rs17173608, rs2235306, rs2236242, and rs2274907, respectively, in rheumatoid arthritis (RA) pathogenesis in Egyptian...
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MDPI AG
2021-09-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/10/976 |
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| author | Alaa S. Wahba Maha E. Ibrahim Dina M. Abo-elmatty Eman T. Mehanna |
| author_facet | Alaa S. Wahba Maha E. Ibrahim Dina M. Abo-elmatty Eman T. Mehanna |
| author_sort | Alaa S. Wahba |
| collection | DOAJ |
| description | Adipokines were shown to exert crucial roles in rheumatic diseases. This study aimed to assess the role of chemerin, apelin, vaspin, and omentin adipokines and their genetic variants rs17173608, rs2235306, rs2236242, and rs2274907, respectively, in rheumatoid arthritis (RA) pathogenesis in Egyptian patients. A total of 150 RA patients and 150 healthy individuals were recruited. Blood samples were collected and used for genotyping. Serum was separated and used for expression analysis by quantitative PCR, and various biochemical markers determination by ELISA. Serum protein levels of chemerin and vaspin, as well as their gene expression levels were higher, while those of apelin and omentin were lower in RA patients and were associated with most of RA clinical and laboratory characteristics. G allele of chemerin rs17173608, T allele of vaspin rs2236242, and T allele of omentin rs2274907 were more frequent in RA patients. Serum levels and gene expression levels of chemerin in GG genotype carriers and vaspin in TT genotype group were significantly higher, while those of omentin in TT genotype carriers were significantly lower than RA patients with other genotypes. There was no association between apelin rs2235306 and RA. Chemerin rs17173608, vaspin rs2236242, and omentin rs2274907 polymorphisms were associated with increased susceptibility to RA. |
| first_indexed | 2024-03-10T06:28:01Z |
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| id | doaj.art-8c0f7318f9ae4027ab931fe15f311a4a |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T06:28:01Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-8c0f7318f9ae4027ab931fe15f311a4a2023-11-22T18:48:39ZengMDPI AGJournal of Personalized Medicine2075-44262021-09-01111097610.3390/jpm11100976Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid ArthritisAlaa S. Wahba0Maha E. Ibrahim1Dina M. Abo-elmatty2Eman T. Mehanna3Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, EgyptDepartment of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Suez Canal University, Ismailia 41522, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, EgyptAdipokines were shown to exert crucial roles in rheumatic diseases. This study aimed to assess the role of chemerin, apelin, vaspin, and omentin adipokines and their genetic variants rs17173608, rs2235306, rs2236242, and rs2274907, respectively, in rheumatoid arthritis (RA) pathogenesis in Egyptian patients. A total of 150 RA patients and 150 healthy individuals were recruited. Blood samples were collected and used for genotyping. Serum was separated and used for expression analysis by quantitative PCR, and various biochemical markers determination by ELISA. Serum protein levels of chemerin and vaspin, as well as their gene expression levels were higher, while those of apelin and omentin were lower in RA patients and were associated with most of RA clinical and laboratory characteristics. G allele of chemerin rs17173608, T allele of vaspin rs2236242, and T allele of omentin rs2274907 were more frequent in RA patients. Serum levels and gene expression levels of chemerin in GG genotype carriers and vaspin in TT genotype group were significantly higher, while those of omentin in TT genotype carriers were significantly lower than RA patients with other genotypes. There was no association between apelin rs2235306 and RA. Chemerin rs17173608, vaspin rs2236242, and omentin rs2274907 polymorphisms were associated with increased susceptibility to RA.https://www.mdpi.com/2075-4426/11/10/976rheumatoid arthritis (RA)chemerinvaspinapelinomentin |
| spellingShingle | Alaa S. Wahba Maha E. Ibrahim Dina M. Abo-elmatty Eman T. Mehanna Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid Arthritis Journal of Personalized Medicine rheumatoid arthritis (RA) chemerin vaspin apelin omentin |
| title | Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid Arthritis |
| title_full | Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid Arthritis |
| title_fullStr | Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid Arthritis |
| title_full_unstemmed | Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid Arthritis |
| title_short | Association of the Adipokines Chemerin, Apelin, Vaspin and Omentin and Their Functional Genetic Variants with Rheumatoid Arthritis |
| title_sort | association of the adipokines chemerin apelin vaspin and omentin and their functional genetic variants with rheumatoid arthritis |
| topic | rheumatoid arthritis (RA) chemerin vaspin apelin omentin |
| url | https://www.mdpi.com/2075-4426/11/10/976 |
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