Chromatin remodeling, cell proliferation and cell death in valproic acid-treated HeLa cells.

Chromatin remodeling, cell proliferation and cell death in valproic acid-treated HeLa cells.

BACKGROUND: Valproic acid (VPA) is a potent anticonvulsant that inhibits histone deacetylases. Because of this inhibitory action, we investigated whether VPA would affect chromatin supraorganization, mitotic indices and the frequency of chromosome abnormalities and cell death in HeLa cells. METHODOL...

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Bibliographic Details
Main Authors: Marina Barreto Felisbino, Wirla M S C Tamashiro, Maria Luiza S Mello
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3242782?pdf=render

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