Biomimetic Nanocarriers for Cancer Target Therapy
Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo’s protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All toget...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/7/3/111 |
| _version_ | 1797553727710691328 |
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| author | Clara Guido Gabriele Maiorano Barbara Cortese Stefania D’Amone Ilaria Elena Palamà |
| author_facet | Clara Guido Gabriele Maiorano Barbara Cortese Stefania D’Amone Ilaria Elena Palamà |
| author_sort | Clara Guido |
| collection | DOAJ |
| description | Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo’s protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All together, these nano-systems suffer low therapeutic efficacy in vivo because organisms can recognize and remove foreign nanomaterials. To overcome this important issue, different modifications on nanoparticle surfaces were exploited in order to reach the desired therapeutic efficacy eliciting, also, the response of immune system against cancer cells. For this reason, more recently, a new strategy involving cell membrane-covered nanoparticles for biomedical application has been attracting increasing attention. Membranes from red blood cells, platelets, leukocytes, tumor, and stem cells, have been exploited as biomimetic coatings of nanoparticles for evading clearance or stimulated immune system by maintaining in the same way their targeting capability. In this review, the use of different cell sources as coating of biomimetic nanocarriers for cancer therapy is discussed. |
| first_indexed | 2024-03-10T16:20:42Z |
| format | Article |
| id | doaj.art-8c100422b3f642a1a0f069c86a19fb80 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T16:20:42Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-8c100422b3f642a1a0f069c86a19fb802023-11-20T13:42:43ZengMDPI AGBioengineering2306-53542020-09-017311110.3390/bioengineering7030111Biomimetic Nanocarriers for Cancer Target TherapyClara Guido0Gabriele Maiorano1Barbara Cortese2Stefania D’Amone3Ilaria Elena Palamà4Department of Mathematics and Physics, University of Salento, Monteroni Street, 73100 Lecce, ItalyNanotechnology Institute, CNR-NANOTEC, Monteroni Street, 73100 Lecce, ItalyNanotechnology Institute, CNR-NANOTEC, c/o La Sapienza University, Piazzale A. Moro, 00185 Rome, ItalyNanotechnology Institute, CNR-NANOTEC, Monteroni Street, 73100 Lecce, ItalyNanotechnology Institute, CNR-NANOTEC, Monteroni Street, 73100 Lecce, ItalyNanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo’s protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All together, these nano-systems suffer low therapeutic efficacy in vivo because organisms can recognize and remove foreign nanomaterials. To overcome this important issue, different modifications on nanoparticle surfaces were exploited in order to reach the desired therapeutic efficacy eliciting, also, the response of immune system against cancer cells. For this reason, more recently, a new strategy involving cell membrane-covered nanoparticles for biomedical application has been attracting increasing attention. Membranes from red blood cells, platelets, leukocytes, tumor, and stem cells, have been exploited as biomimetic coatings of nanoparticles for evading clearance or stimulated immune system by maintaining in the same way their targeting capability. In this review, the use of different cell sources as coating of biomimetic nanocarriers for cancer therapy is discussed.https://www.mdpi.com/2306-5354/7/3/111biomimetic nanoparticlescancer therapyimmunotherapy |
| spellingShingle | Clara Guido Gabriele Maiorano Barbara Cortese Stefania D’Amone Ilaria Elena Palamà Biomimetic Nanocarriers for Cancer Target Therapy Bioengineering biomimetic nanoparticles cancer therapy immunotherapy |
| title | Biomimetic Nanocarriers for Cancer Target Therapy |
| title_full | Biomimetic Nanocarriers for Cancer Target Therapy |
| title_fullStr | Biomimetic Nanocarriers for Cancer Target Therapy |
| title_full_unstemmed | Biomimetic Nanocarriers for Cancer Target Therapy |
| title_short | Biomimetic Nanocarriers for Cancer Target Therapy |
| title_sort | biomimetic nanocarriers for cancer target therapy |
| topic | biomimetic nanoparticles cancer therapy immunotherapy |
| url | https://www.mdpi.com/2306-5354/7/3/111 |
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