Tracking auditory mismatch negativity responses during full conscious state and coma
The mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, w...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1111691/full |
| _version_ | 1811155499140251648 |
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| author | Adianes Herrera-Diaz Adianes Herrera-Diaz Rober Boshra Paniz Tavakoli Chia-Yu A. Lin Netri Pajankar Netri Pajankar Elham Bagheri Elham Bagheri Richard Kolesar Alison Fox-Robichaud Alison Fox-Robichaud Cindy Hamielec Cindy Hamielec James P. Reilly James P. Reilly John F. Connolly John F. Connolly John F. Connolly John F. Connolly John F. Connolly John F. Connolly |
| author_facet | Adianes Herrera-Diaz Adianes Herrera-Diaz Rober Boshra Paniz Tavakoli Chia-Yu A. Lin Netri Pajankar Netri Pajankar Elham Bagheri Elham Bagheri Richard Kolesar Alison Fox-Robichaud Alison Fox-Robichaud Cindy Hamielec Cindy Hamielec James P. Reilly James P. Reilly John F. Connolly John F. Connolly John F. Connolly John F. Connolly John F. Connolly John F. Connolly |
| author_sort | Adianes Herrera-Diaz |
| collection | DOAJ |
| description | The mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, we tracked auditory MMN responses in seventeen healthy controls over a 12-h period, and in three comatose patients assessed over 24 h at two time points. We investigated whether the MMN responses show fluctuations in detectability over time in full conscious awareness, or whether such fluctuations are rather a feature of coma. Three methods of analysis were utilized to determine whether the MMN and subsequent event-related potential (ERP) components could be identified: traditional visual analysis, permutation t-test, and Bayesian analysis. The results showed that the MMN responses elicited to the duration deviant-stimuli are elicited and reliably detected over the course of several hours in healthy controls, at both group and single-subject levels. Preliminary findings in three comatose patients provide further evidence that the MMN is often present in coma, varying within a single patient from easily detectable to undetectable at different times. This highlights the fact that regular and repeated assessments are extremely important when using MMN as a neurophysiological predictor of coma emergence. |
| first_indexed | 2024-04-10T04:34:01Z |
| format | Article |
| id | doaj.art-8c12fc53865d4c15bbcb6cc15aad2f85 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T04:34:01Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-8c12fc53865d4c15bbcb6cc15aad2f852023-03-10T04:47:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-03-011410.3389/fneur.2023.11116911111691Tracking auditory mismatch negativity responses during full conscious state and comaAdianes Herrera-Diaz0Adianes Herrera-Diaz1Rober Boshra2Paniz Tavakoli3Chia-Yu A. Lin4Netri Pajankar5Netri Pajankar6Elham Bagheri7Elham Bagheri8Richard Kolesar9Alison Fox-Robichaud10Alison Fox-Robichaud11Cindy Hamielec12Cindy Hamielec13James P. Reilly14James P. Reilly15John F. Connolly16John F. Connolly17John F. Connolly18John F. Connolly19John F. Connolly20John F. Connolly21Centre for Advanced Research in Experimental and Applied Linguistics (ARiEAL), McMaster University, Hamilton, ON, CanadaNeuroscience Graduate Program, McMaster University, Hamilton, ON, CanadaPrincenton Neuroscience Institute, Princeton University, Princeton, NJ, United StatesCentre for Advanced Research in Experimental and Applied Linguistics (ARiEAL), McMaster University, Hamilton, ON, CanadaCentre for Advanced Research in Experimental and Applied Linguistics (ARiEAL), McMaster University, Hamilton, ON, CanadaCentre for Advanced Research in Experimental and Applied Linguistics (ARiEAL), McMaster University, Hamilton, ON, CanadaNeuroscience Graduate Program, McMaster University, Hamilton, ON, CanadaCentre for Advanced Research in Experimental and Applied Linguistics (ARiEAL), McMaster University, Hamilton, ON, CanadaSchool of Biomedical Engineering, McMaster University, Hamilton, ON, CanadaDepartment of Anesthesia, McMaster University, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaCritical Care Medicine, Hamilton Health Sciences, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaCritical Care Medicine, Hamilton Health Sciences, Hamilton, ON, CanadaCentre for Advanced Research in Experimental and Applied Linguistics (ARiEAL), McMaster University, Hamilton, ON, CanadaSchool of Biomedical Engineering, McMaster University, Hamilton, ON, CanadaCentre for Advanced Research in Experimental and Applied Linguistics (ARiEAL), McMaster University, Hamilton, ON, CanadaNeuroscience Graduate Program, McMaster University, Hamilton, ON, CanadaSchool of Biomedical Engineering, McMaster University, Hamilton, ON, CanadaDepartment of Anesthesia, McMaster University, Hamilton, ON, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, CanadaVoxNeuro, Inc., Toronto, ON, CanadaThe mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, we tracked auditory MMN responses in seventeen healthy controls over a 12-h period, and in three comatose patients assessed over 24 h at two time points. We investigated whether the MMN responses show fluctuations in detectability over time in full conscious awareness, or whether such fluctuations are rather a feature of coma. Three methods of analysis were utilized to determine whether the MMN and subsequent event-related potential (ERP) components could be identified: traditional visual analysis, permutation t-test, and Bayesian analysis. The results showed that the MMN responses elicited to the duration deviant-stimuli are elicited and reliably detected over the course of several hours in healthy controls, at both group and single-subject levels. Preliminary findings in three comatose patients provide further evidence that the MMN is often present in coma, varying within a single patient from easily detectable to undetectable at different times. This highlights the fact that regular and repeated assessments are extremely important when using MMN as a neurophysiological predictor of coma emergence.https://www.frontiersin.org/articles/10.3389/fneur.2023.1111691/fullmismatch negativityevent-related potentials (ERP)comadisorder of consciousnessbrain injury |
| spellingShingle | Adianes Herrera-Diaz Adianes Herrera-Diaz Rober Boshra Paniz Tavakoli Chia-Yu A. Lin Netri Pajankar Netri Pajankar Elham Bagheri Elham Bagheri Richard Kolesar Alison Fox-Robichaud Alison Fox-Robichaud Cindy Hamielec Cindy Hamielec James P. Reilly James P. Reilly John F. Connolly John F. Connolly John F. Connolly John F. Connolly John F. Connolly John F. Connolly Tracking auditory mismatch negativity responses during full conscious state and coma Frontiers in Neurology mismatch negativity event-related potentials (ERP) coma disorder of consciousness brain injury |
| title | Tracking auditory mismatch negativity responses during full conscious state and coma |
| title_full | Tracking auditory mismatch negativity responses during full conscious state and coma |
| title_fullStr | Tracking auditory mismatch negativity responses during full conscious state and coma |
| title_full_unstemmed | Tracking auditory mismatch negativity responses during full conscious state and coma |
| title_short | Tracking auditory mismatch negativity responses during full conscious state and coma |
| title_sort | tracking auditory mismatch negativity responses during full conscious state and coma |
| topic | mismatch negativity event-related potentials (ERP) coma disorder of consciousness brain injury |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1111691/full |
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