COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS
Introduction: Based on epidemiological data, the periodontitis prevalence in Indonesia reached 96.58%. Periodontitis is a periodontal disease caused by specific microorganisms causing attachment loss, alveolar bone resorption, and periodontal pocket. The pocket which is more than 6 mm couldn’t be ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Universitas Islam Sultan Agung
2020-08-01
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| Series: | ODONTO: Dental Journal |
| Subjects: | |
| Online Access: | http://jurnal.unissula.ac.id/index.php/odj/article/view/7664 |
| _version_ | 1818176221187407872 |
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| author | Atik Kurniawati Dwi Riski Saputra Dewi Yunita Sari Indhi Cinthiya Amanitha Siti Nurul Masruroh Hariyati |
| author_facet | Atik Kurniawati Dwi Riski Saputra Dewi Yunita Sari Indhi Cinthiya Amanitha Siti Nurul Masruroh Hariyati |
| author_sort | Atik Kurniawati |
| collection | DOAJ |
| description | Introduction: Based on epidemiological data, the periodontitis prevalence in Indonesia reached 96.58%. Periodontitis is a periodontal disease caused by specific microorganisms causing attachment loss, alveolar bone resorption, and periodontal pocket. The pocket which is more than 6 mm couldn’t be carried out using standard care. Therefore bone grafting is needed to fix the bone defect. Cowhide Gelatin nanoparticle (GNPs) combined with Titanium-Prepared Platelet-Rich Fibrin (T-PRF) is an innovative healing of periodontitis.
Objective: To review the potential of cowhide gelatin nanoparticles combined with titanium-prepared platelet-rich fibrin (T-PRF) as an innovation in the healing of periodontitis defects.
Literature review: Cowhide GNPs are the main ingredients for the bone replacement, which are nano-sized, biocompatible, bioactive, osteoconductive, non-toxic, and have a porous structure that supports the drug-delivery process. T-PRF contains platelets, fibrin, growth factors that can stimulate bone regeneration.
Discussion: GNPs support the attachment and proliferation of osteoblast cells and the formation of mineralized bone matrix. The contents of T-PRF, which are fibrin, platelets, and growth factors, one of TGF-β1 will produce bone formation and periodontal healing in the large number. Moreover, T-PRF has leukocyte-fibrin, which may give an antibacterial effect. Thus, GNPs combined with T-PRF have more potent properties that support each other in carrying out their functions to stimulate the healing process.
Conclusion: The combination of cowhide gelatin nanoparticles (GNPs) and titanium-prepared platelet-rich fibrin (T-PRF) has the potential to be effective in bone regeneration in periodontitis defects. |
| first_indexed | 2024-12-11T20:12:44Z |
| format | Article |
| id | doaj.art-8c1430815acb470c930d47ba8e503887 |
| institution | Directory Open Access Journal |
| issn | 2354-5992 2460-4119 |
| language | English |
| last_indexed | 2024-12-11T20:12:44Z |
| publishDate | 2020-08-01 |
| publisher | Universitas Islam Sultan Agung |
| record_format | Article |
| series | ODONTO: Dental Journal |
| spelling | doaj.art-8c1430815acb470c930d47ba8e5038872022-12-22T00:52:15ZengUniversitas Islam Sultan AgungODONTO: Dental Journal2354-59922460-41192020-08-0171738110.30659/odj.7.1.73-814336COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESSAtik Kurniawati0Dwi Riski Saputra1Dewi Yunita Sari2Indhi Cinthiya Amanitha3Siti Nurul Masruroh HariyatiDentistry Faculty of Jember UniversityDentistry Faculty of Jember UniversityUniversitas Negeri JemberUniversitas Negeri JemberIntroduction: Based on epidemiological data, the periodontitis prevalence in Indonesia reached 96.58%. Periodontitis is a periodontal disease caused by specific microorganisms causing attachment loss, alveolar bone resorption, and periodontal pocket. The pocket which is more than 6 mm couldn’t be carried out using standard care. Therefore bone grafting is needed to fix the bone defect. Cowhide Gelatin nanoparticle (GNPs) combined with Titanium-Prepared Platelet-Rich Fibrin (T-PRF) is an innovative healing of periodontitis. Objective: To review the potential of cowhide gelatin nanoparticles combined with titanium-prepared platelet-rich fibrin (T-PRF) as an innovation in the healing of periodontitis defects. Literature review: Cowhide GNPs are the main ingredients for the bone replacement, which are nano-sized, biocompatible, bioactive, osteoconductive, non-toxic, and have a porous structure that supports the drug-delivery process. T-PRF contains platelets, fibrin, growth factors that can stimulate bone regeneration. Discussion: GNPs support the attachment and proliferation of osteoblast cells and the formation of mineralized bone matrix. The contents of T-PRF, which are fibrin, platelets, and growth factors, one of TGF-β1 will produce bone formation and periodontal healing in the large number. Moreover, T-PRF has leukocyte-fibrin, which may give an antibacterial effect. Thus, GNPs combined with T-PRF have more potent properties that support each other in carrying out their functions to stimulate the healing process. Conclusion: The combination of cowhide gelatin nanoparticles (GNPs) and titanium-prepared platelet-rich fibrin (T-PRF) has the potential to be effective in bone regeneration in periodontitis defects.http://jurnal.unissula.ac.id/index.php/odj/article/view/7664gelatin nanoparticlesperiodontitist-prf |
| spellingShingle | Atik Kurniawati Dwi Riski Saputra Dewi Yunita Sari Indhi Cinthiya Amanitha Siti Nurul Masruroh Hariyati COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS ODONTO: Dental Journal gelatin nanoparticles periodontitis t-prf |
| title | COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS |
| title_full | COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS |
| title_fullStr | COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS |
| title_full_unstemmed | COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS |
| title_short | COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS |
| title_sort | cowhide gelatin nanoparticles and titanium prepared platelet rich fibrin potential in periodontitis healing process |
| topic | gelatin nanoparticles periodontitis t-prf |
| url | http://jurnal.unissula.ac.id/index.php/odj/article/view/7664 |
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