Dietary and lifestyle associations with microbiome diversity
Abstract Background Microbial dysbiosis has been closely linked with colorectal cancer development. However, data is limited regarding the relationship of the mucosal microbiome, adenomatous polyps and dietary habits. Understanding these associations may elucidate pathways for risk stratification ac...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
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| Series: | Gut Pathogens |
| Online Access: | https://doi.org/10.1186/s13099-022-00525-w |
| _version_ | 1797977416007680000 |
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| author | Katherine M. Watson Kyla N. Siemens Sudarshan Anand Ivy H. Gardner Thomas J. Sharpton Elizabeth N. Dewey Robert Martindale Christopher A. Gaulke Vassiliki Liana Tsikitis |
| author_facet | Katherine M. Watson Kyla N. Siemens Sudarshan Anand Ivy H. Gardner Thomas J. Sharpton Elizabeth N. Dewey Robert Martindale Christopher A. Gaulke Vassiliki Liana Tsikitis |
| author_sort | Katherine M. Watson |
| collection | DOAJ |
| description | Abstract Background Microbial dysbiosis has been closely linked with colorectal cancer development. However, data is limited regarding the relationship of the mucosal microbiome, adenomatous polyps and dietary habits. Understanding these associations may elucidate pathways for risk stratification according to diet. Results Patients undergoing screening colonoscopy were included in our prospective, single center study and divided into adenoma or no adenoma cohorts. Oral, fecal, and mucosal samples were obtained. Microbial DNA was extracted, and amplicon libraries generated using primers for the 16S rRNA gene V4 region. Patient and dietary information was collected. Of 104 participants, 44% presented with polyps, which were predominantly tubular adenomas (87%). Adenoma formation and multiple patient dietary and lifestyle characteristics were associated with mucosal microbiome diversity. Lifestyle factors included age, body mass index, adenoma number, and dietary consumption of red meats, processed meats, vegetables, fruit, grain, fermented foods and alcohol. Conclusion In this study we showed associations between dietary habits, adenoma formation and the mucosal microbiome. These early findings suggest that ongoing research into diet modification may help reduce adenoma formation and subsequently the development of CRC. |
| first_indexed | 2024-04-11T05:06:34Z |
| format | Article |
| id | doaj.art-8c145efae3a94e998eb3606d7cbb68fc |
| institution | Directory Open Access Journal |
| issn | 1757-4749 |
| language | English |
| last_indexed | 2024-04-11T05:06:34Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Gut Pathogens |
| spelling | doaj.art-8c145efae3a94e998eb3606d7cbb68fc2022-12-25T12:17:53ZengBMCGut Pathogens1757-47492022-12-011411610.1186/s13099-022-00525-wDietary and lifestyle associations with microbiome diversityKatherine M. Watson0Kyla N. Siemens1Sudarshan Anand2Ivy H. Gardner3Thomas J. Sharpton4Elizabeth N. Dewey5Robert Martindale6Christopher A. Gaulke7Vassiliki Liana Tsikitis8Department of Surgery, Oregon Health & Science UniversityDepartment of Surgery, Oregon Health & Science UniversityDepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science UniversityDepartment of Surgery, Oregon Health & Science UniversityDepartment of Microbiology, Oregon State UniversityDepartment of Surgery, Oregon Health & Science UniversityDepartment of Surgery, Oregon Health & Science UniversityDepartment of Pathobiology, University of Illinois Urbana-ChampaignDepartment of Surgery, Oregon Health & Science UniversityAbstract Background Microbial dysbiosis has been closely linked with colorectal cancer development. However, data is limited regarding the relationship of the mucosal microbiome, adenomatous polyps and dietary habits. Understanding these associations may elucidate pathways for risk stratification according to diet. Results Patients undergoing screening colonoscopy were included in our prospective, single center study and divided into adenoma or no adenoma cohorts. Oral, fecal, and mucosal samples were obtained. Microbial DNA was extracted, and amplicon libraries generated using primers for the 16S rRNA gene V4 region. Patient and dietary information was collected. Of 104 participants, 44% presented with polyps, which were predominantly tubular adenomas (87%). Adenoma formation and multiple patient dietary and lifestyle characteristics were associated with mucosal microbiome diversity. Lifestyle factors included age, body mass index, adenoma number, and dietary consumption of red meats, processed meats, vegetables, fruit, grain, fermented foods and alcohol. Conclusion In this study we showed associations between dietary habits, adenoma formation and the mucosal microbiome. These early findings suggest that ongoing research into diet modification may help reduce adenoma formation and subsequently the development of CRC.https://doi.org/10.1186/s13099-022-00525-w |
| spellingShingle | Katherine M. Watson Kyla N. Siemens Sudarshan Anand Ivy H. Gardner Thomas J. Sharpton Elizabeth N. Dewey Robert Martindale Christopher A. Gaulke Vassiliki Liana Tsikitis Dietary and lifestyle associations with microbiome diversity Gut Pathogens |
| title | Dietary and lifestyle associations with microbiome diversity |
| title_full | Dietary and lifestyle associations with microbiome diversity |
| title_fullStr | Dietary and lifestyle associations with microbiome diversity |
| title_full_unstemmed | Dietary and lifestyle associations with microbiome diversity |
| title_short | Dietary and lifestyle associations with microbiome diversity |
| title_sort | dietary and lifestyle associations with microbiome diversity |
| url | https://doi.org/10.1186/s13099-022-00525-w |
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