Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunction
Background: Adenosine deaminase (ADA) is a cytosolic enzyme, which participates in development and maintenance of the immune system. Diabetic patients have a higher prevalence of thyroid disorders compared to the normal population because patients with one organ-specific autoimmune disease are at ri...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-07-01
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| Series: | MRIMS Journal of Health Sciences |
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| Online Access: | http://mrimsjournal.com/wp-content/uploads/2013/07/5.pdf |
| _version_ | 1818548665168429056 |
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| author | Vishnu Madhuri V. Sampath Kumar Shruti Mohanty |
| author_facet | Vishnu Madhuri V. Sampath Kumar Shruti Mohanty |
| author_sort | Vishnu Madhuri |
| collection | DOAJ |
| description | Background: Adenosine deaminase (ADA) is a cytosolic enzyme, which participates in development and maintenance of the immune system. Diabetic patients have a higher prevalence of thyroid disorders compared to the normal population because patients with one organ-specific autoimmune disease are at risk of developing other autoimmune disorders. Methods: A total number of one hundred subjects were divided into four groups consist of group A. Type II Diabetic patients, group B. Hypothyroid patients, group C. Hyperthyroid patients and group D. Healthy controls of either sex between age group of 30-70 years. The following biochemical parameters were estimated for all the groups. Fasting plasma glucose, Serum T3, T4, TSH and Adenosine deaminase. Results: Mean serum ADA levels were raised in diabetic and hypothyroid patients when compared to that in controls and which was statistically significant (p<0.0001). Unlike hypothyroid, serum ADA levels in hyperthyroid patients were within normal limits. Conclusion: Increase in serum ADA levels in the diabetic and the hypothyroid patients when compared to controls, are suggestive of an association with a common immunological disturbance. Increase in serum TSH levels in diabetes patient increase in fasting blood sugar level in hypothyroid patients, when compared to healthy controls is suggestive of diabetic patients probably suffering from subclinical hypothyroidism and patients with hypothyroidism suffering from impaired glucose metabolism. |
| first_indexed | 2024-12-12T08:23:13Z |
| format | Article |
| id | doaj.art-8c1501ecce7f4b94af7b9ad459c3760d |
| institution | Directory Open Access Journal |
| issn | 2321-7006 2321-7294 |
| language | English |
| last_indexed | 2024-12-12T08:23:13Z |
| publishDate | 2013-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MRIMS Journal of Health Sciences |
| spelling | doaj.art-8c1501ecce7f4b94af7b9ad459c3760d2022-12-22T00:31:21ZengWolters Kluwer Medknow PublicationsMRIMS Journal of Health Sciences2321-70062321-72942013-07-01111719Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunctionVishnu MadhuriV. Sampath KumarShruti MohantyBackground: Adenosine deaminase (ADA) is a cytosolic enzyme, which participates in development and maintenance of the immune system. Diabetic patients have a higher prevalence of thyroid disorders compared to the normal population because patients with one organ-specific autoimmune disease are at risk of developing other autoimmune disorders. Methods: A total number of one hundred subjects were divided into four groups consist of group A. Type II Diabetic patients, group B. Hypothyroid patients, group C. Hyperthyroid patients and group D. Healthy controls of either sex between age group of 30-70 years. The following biochemical parameters were estimated for all the groups. Fasting plasma glucose, Serum T3, T4, TSH and Adenosine deaminase. Results: Mean serum ADA levels were raised in diabetic and hypothyroid patients when compared to that in controls and which was statistically significant (p<0.0001). Unlike hypothyroid, serum ADA levels in hyperthyroid patients were within normal limits. Conclusion: Increase in serum ADA levels in the diabetic and the hypothyroid patients when compared to controls, are suggestive of an association with a common immunological disturbance. Increase in serum TSH levels in diabetes patient increase in fasting blood sugar level in hypothyroid patients, when compared to healthy controls is suggestive of diabetic patients probably suffering from subclinical hypothyroidism and patients with hypothyroidism suffering from impaired glucose metabolism.http://mrimsjournal.com/wp-content/uploads/2013/07/5.pdfAdenosine deaminaseDiabetes mellitusHyperthyroidismHypothyroidism |
| spellingShingle | Vishnu Madhuri V. Sampath Kumar Shruti Mohanty Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunction MRIMS Journal of Health Sciences Adenosine deaminase Diabetes mellitus Hyperthyroidism Hypothyroidism |
| title | Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunction |
| title_full | Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunction |
| title_fullStr | Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunction |
| title_full_unstemmed | Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunction |
| title_short | Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunction |
| title_sort | role of ada in immunological disorders diabetes mellitus and thyroid dysfunction |
| topic | Adenosine deaminase Diabetes mellitus Hyperthyroidism Hypothyroidism |
| url | http://mrimsjournal.com/wp-content/uploads/2013/07/5.pdf |
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