Effects of Dietary Calcium on Body Weight, Carcass Fat Content and Adipocyte Size in Male Rats
Introduction & Objective: Calcium is a micronutrient and now receiving much attention for its doubtful effects on weight and body fatness. A few mechanisms has been suggested for calcium effects on body fatness and the most emphasized one is the reducing of lipolysis and increasing lipogenesis v...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Yasuj University Of Medical Sciences
2006-07-01
|
| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-39-107&slc_lang=en&sid=1 |
| _version_ | 1811203086289469440 |
|---|---|
| author | J Malekzadeh SA Keshavarz F Siassi M Kadkhodaei MR Eshraghian AR Dorosti Motlagh A Aliehpoor M Chamari |
| author_facet | J Malekzadeh SA Keshavarz F Siassi M Kadkhodaei MR Eshraghian AR Dorosti Motlagh A Aliehpoor M Chamari |
| author_sort | J Malekzadeh |
| collection | DOAJ |
| description | Introduction & Objective: Calcium is a micronutrient and now receiving much attention for its doubtful effects on weight and body fatness. A few mechanisms has been suggested for calcium effects on body fatness and the most emphasized one is the reducing of lipolysis and increasing lipogenesis via reducing parathyroid hormone levels. The present study is designed to evaluate the effects of nondairy dietary calcium on adipogenesis and adipocyte size in male Sprague dawley rats.
Materials & Methods: This experimental study was done from November to September of 2005 at Tehran school of health, nutrition department. 48 male Spragu-Dawley rats from Damgostar Company were used in three randomly selected groups. The rats were fed low (0.2% W/W), usual (0.5% W/W) and high (1.2% W/W) dietary calcium based on AIN-93M purified diet. Rats were housed in 12 hours light-dark cycle, 22-25°C room temperature with free access to their respective diets. At the end of the experiment, rats were decapitated and carcass fat content, carcass ash content and mean adipocyte size in testis, peritoneal and subcutaneous fat pads were compared in three groups. The SPSS 11.5 was used as statistical software, running analysis of variance for comparing the effects.
Results: weight gain, carcass fat content and adipocyte size, in groups were not significantly different, while serum parathyroid hormone concentrations in high calcium group was significantly lower than low calcium group (p<0.05) and insignificantly lower than usual calcium group [12.36, 23.57 and 42.2 pg/dl respectively]. Serum concentrations of 25-hydroxy cholecalciferol were also insignificantly lower in high calcium group.
Conclusion: Our findings suggested that physiological concentration of dietary calcium is not effective on weight gain, body fatness and adipocyte size. Relatively equal fat content beside significant difference in serum parathyroid hormone levels is against the parathyroid theory of calcium effects on body fatness. Finally we do not suggest any effect for calcium on body fatness and adipocyte size. |
| first_indexed | 2024-04-12T02:49:42Z |
| format | Article |
| id | doaj.art-8c15ca0616ad486bb70d52d740a62b63 |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-12T02:49:42Z |
| publishDate | 2006-07-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-8c15ca0616ad486bb70d52d740a62b632022-12-22T03:51:03ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142006-07-011128393Effects of Dietary Calcium on Body Weight, Carcass Fat Content and Adipocyte Size in Male RatsJ Malekzadeh0SA Keshavarz1F Siassi2M Kadkhodaei3MR Eshraghian4AR Dorosti Motlagh5A Aliehpoor6M Chamari7 Introduction & Objective: Calcium is a micronutrient and now receiving much attention for its doubtful effects on weight and body fatness. A few mechanisms has been suggested for calcium effects on body fatness and the most emphasized one is the reducing of lipolysis and increasing lipogenesis via reducing parathyroid hormone levels. The present study is designed to evaluate the effects of nondairy dietary calcium on adipogenesis and adipocyte size in male Sprague dawley rats. Materials & Methods: This experimental study was done from November to September of 2005 at Tehran school of health, nutrition department. 48 male Spragu-Dawley rats from Damgostar Company were used in three randomly selected groups. The rats were fed low (0.2% W/W), usual (0.5% W/W) and high (1.2% W/W) dietary calcium based on AIN-93M purified diet. Rats were housed in 12 hours light-dark cycle, 22-25°C room temperature with free access to their respective diets. At the end of the experiment, rats were decapitated and carcass fat content, carcass ash content and mean adipocyte size in testis, peritoneal and subcutaneous fat pads were compared in three groups. The SPSS 11.5 was used as statistical software, running analysis of variance for comparing the effects. Results: weight gain, carcass fat content and adipocyte size, in groups were not significantly different, while serum parathyroid hormone concentrations in high calcium group was significantly lower than low calcium group (p<0.05) and insignificantly lower than usual calcium group [12.36, 23.57 and 42.2 pg/dl respectively]. Serum concentrations of 25-hydroxy cholecalciferol were also insignificantly lower in high calcium group. Conclusion: Our findings suggested that physiological concentration of dietary calcium is not effective on weight gain, body fatness and adipocyte size. Relatively equal fat content beside significant difference in serum parathyroid hormone levels is against the parathyroid theory of calcium effects on body fatness. Finally we do not suggest any effect for calcium on body fatness and adipocyte size.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-39-107&slc_lang=en&sid=1Dietary Calcium Obesity Adipocyte |
| spellingShingle | J Malekzadeh SA Keshavarz F Siassi M Kadkhodaei MR Eshraghian AR Dorosti Motlagh A Aliehpoor M Chamari Effects of Dietary Calcium on Body Weight, Carcass Fat Content and Adipocyte Size in Male Rats Armaghane Danesh Bimonthly Journal Dietary Calcium Obesity Adipocyte |
| title | Effects of Dietary Calcium on Body Weight, Carcass Fat Content and Adipocyte Size in Male Rats |
| title_full | Effects of Dietary Calcium on Body Weight, Carcass Fat Content and Adipocyte Size in Male Rats |
| title_fullStr | Effects of Dietary Calcium on Body Weight, Carcass Fat Content and Adipocyte Size in Male Rats |
| title_full_unstemmed | Effects of Dietary Calcium on Body Weight, Carcass Fat Content and Adipocyte Size in Male Rats |
| title_short | Effects of Dietary Calcium on Body Weight, Carcass Fat Content and Adipocyte Size in Male Rats |
| title_sort | effects of dietary calcium on body weight carcass fat content and adipocyte size in male rats |
| topic | Dietary Calcium Obesity Adipocyte |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-39-107&slc_lang=en&sid=1 |
| work_keys_str_mv | AT jmalekzadeh effectsofdietarycalciumonbodyweightcarcassfatcontentandadipocytesizeinmalerats AT sakeshavarz effectsofdietarycalciumonbodyweightcarcassfatcontentandadipocytesizeinmalerats AT fsiassi effectsofdietarycalciumonbodyweightcarcassfatcontentandadipocytesizeinmalerats AT mkadkhodaei effectsofdietarycalciumonbodyweightcarcassfatcontentandadipocytesizeinmalerats AT mreshraghian effectsofdietarycalciumonbodyweightcarcassfatcontentandadipocytesizeinmalerats AT ardorostimotlagh effectsofdietarycalciumonbodyweightcarcassfatcontentandadipocytesizeinmalerats AT aaliehpoor effectsofdietarycalciumonbodyweightcarcassfatcontentandadipocytesizeinmalerats AT mchamari effectsofdietarycalciumonbodyweightcarcassfatcontentandadipocytesizeinmalerats |