Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease which can affect various tissues and organs, posing significant challenges for clinical diagnosis and treatment. The etiology of SLE is highly complex with contributions from environmental factors, stochastic factors as well a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.808839/full |
| _version_ | 1819364591976579072 |
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| author | Gongjun Tan Binila Baby Yuqiu Zhou Tianfu Wu |
| author_facet | Gongjun Tan Binila Baby Yuqiu Zhou Tianfu Wu |
| author_sort | Gongjun Tan |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease which can affect various tissues and organs, posing significant challenges for clinical diagnosis and treatment. The etiology of SLE is highly complex with contributions from environmental factors, stochastic factors as well as genetic susceptibility. The current criteria for diagnosing SLE is based primarily on a combination of clinical presentations and traditional lab testing. However, these tests have suboptimal sensitivity and specificity. They are unable to indicate disease cause or guide physicians in decision-making for treatment. Therefore, there is an urgent need to develop a more accurate and robust tool for effective clinical management and drug development in lupus patients. It is fortunate that the emerging Omics have empowered scientists in the discovery and identification of potential novel biomarkers of SLE, especially the markers from blood, urine, cerebrospinal fluids (CSF), and other bodily fluids. However, many of these markers have not been carefully validated for clinical use. In addition, it is apparent that individual biomarkers lack sensitivity or specificity. This review summarizes the sensitivity, specificity and diagnostic value of emerging biomarkers from recent studies, and discusses the potential of these markers in the development of biomarker panel based diagnostics or disease monitoring system in SLE. |
| first_indexed | 2024-12-24T23:01:23Z |
| format | Article |
| id | doaj.art-8c15ed576fb049948f2d4f492b1d04f2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T23:01:23Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8c15ed576fb049948f2d4f492b1d04f22022-12-21T16:35:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-01-011210.3389/fimmu.2021.808839808839Emerging Molecular Markers Towards Potential Diagnostic Panels for LupusGongjun Tan0Binila Baby1Yuqiu Zhou2Tianfu Wu3Department of Clinical Laboratory, Zhuhai Maternal and Child Healthcare Hospital, Zhuhai, ChinaDepartment of Biomedical Engineering, University of Houston, Houston, TX, United StatesDepartment of Clinical Laboratory, Zhuhai Maternal and Child Healthcare Hospital, Zhuhai, ChinaDepartment of Biomedical Engineering, University of Houston, Houston, TX, United StatesSystemic lupus erythematosus (SLE) is a multifactorial autoimmune disease which can affect various tissues and organs, posing significant challenges for clinical diagnosis and treatment. The etiology of SLE is highly complex with contributions from environmental factors, stochastic factors as well as genetic susceptibility. The current criteria for diagnosing SLE is based primarily on a combination of clinical presentations and traditional lab testing. However, these tests have suboptimal sensitivity and specificity. They are unable to indicate disease cause or guide physicians in decision-making for treatment. Therefore, there is an urgent need to develop a more accurate and robust tool for effective clinical management and drug development in lupus patients. It is fortunate that the emerging Omics have empowered scientists in the discovery and identification of potential novel biomarkers of SLE, especially the markers from blood, urine, cerebrospinal fluids (CSF), and other bodily fluids. However, many of these markers have not been carefully validated for clinical use. In addition, it is apparent that individual biomarkers lack sensitivity or specificity. This review summarizes the sensitivity, specificity and diagnostic value of emerging biomarkers from recent studies, and discusses the potential of these markers in the development of biomarker panel based diagnostics or disease monitoring system in SLE.https://www.frontiersin.org/articles/10.3389/fimmu.2021.808839/fullomicsbiomarker panelSLEdisease monitoringlupus nephritisneuropsychiatric lupus (NPSLE) |
| spellingShingle | Gongjun Tan Binila Baby Yuqiu Zhou Tianfu Wu Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus Frontiers in Immunology omics biomarker panel SLE disease monitoring lupus nephritis neuropsychiatric lupus (NPSLE) |
| title | Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus |
| title_full | Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus |
| title_fullStr | Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus |
| title_full_unstemmed | Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus |
| title_short | Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus |
| title_sort | emerging molecular markers towards potential diagnostic panels for lupus |
| topic | omics biomarker panel SLE disease monitoring lupus nephritis neuropsychiatric lupus (NPSLE) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.808839/full |
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