Carbonate apatite nanoparticles: A novel nano-adjuvant for oral mucosal vaccines and immunomodulator
Vaccines manufacture and enhancement for preventing infection and promoting quality of life are of great concern worldwide. For vaccine enhancement, to date, only limited adjuvants have been approved globally. One of them is alum, which presents several side effects and limitations. Related to vacci...
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Format: | Article |
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Elsevier
2023-07-01
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Series: | OpenNano |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2352952023000282 |
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author | Andari Sarasati Hevi Wihadmadyatami Ika Dewi Ana |
author_facet | Andari Sarasati Hevi Wihadmadyatami Ika Dewi Ana |
author_sort | Andari Sarasati |
collection | DOAJ |
description | Vaccines manufacture and enhancement for preventing infection and promoting quality of life are of great concern worldwide. For vaccine enhancement, to date, only limited adjuvants have been approved globally. One of them is alum, which presents several side effects and limitations. Related to vaccine administration, mucosal vaccination is a promising method since it can induce both mucosal and systemic immunity since oral mucosa is the most exposed site of the body to various microbes, pathogens, and environmental particles. Consequently, an escalated specific local immunity is required in which stability and integrity of an encapsulated antigen is expected to result in a stable mucosal vaccine to protect the antigens from degradative chemical reactions occurring in the oral cavity and act as immunomodulator. Carbonate apatite (CHA) has been one of the most innovative materials as a newly developed vaccine adjuvant since it can adequately enhance drug and protein stability and delivery in various disease therapies. However, CHA fabrication that meets the parameters for adjuvants and immunomodulators remains challenging. In the form of nanoparticles, CHA is reported to enable targeted delivery of dendritic cells (DC), enhance uptakes, cross presentation, and biodistribution, as well as immune responses. Therefore, the development of nano-CHA-encapsulated vaccine antigens is required to enhance oral mucosal vaccinations and their effectiveness to prevent diseases. This study focuses on factors and strategies that affect the designing, fabrication, and testing of CHA nanoparticles for oral mucosal vaccines, especially in the aspect of physicochemical, immunological, cellular, surface chemistry, and biofunctionalization of the nanoparticle. |
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format | Article |
id | doaj.art-8c179effbf434eafa566c9c0788322c2 |
institution | Directory Open Access Journal |
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language | English |
last_indexed | 2024-03-13T05:28:33Z |
publishDate | 2023-07-01 |
publisher | Elsevier |
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series | OpenNano |
spelling | doaj.art-8c179effbf434eafa566c9c0788322c22023-06-15T04:56:31ZengElsevierOpenNano2352-95202023-07-0112100149Carbonate apatite nanoparticles: A novel nano-adjuvant for oral mucosal vaccines and immunomodulatorAndari Sarasati0Hevi Wihadmadyatami1Ika Dewi Ana2Doctoral Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaDepartment of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Research Collaboration Center for Biomedical Scaffolds, National Research and Innovation Agency (BRIN) and Universitas Gadjah Mada (UGM), Bulaksumur, Yogyakarta 55281, IndonesiaDepartment of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Research Collaboration Center for Biomedical Scaffolds, National Research and Innovation Agency (BRIN) and Universitas Gadjah Mada (UGM), Bulaksumur, Yogyakarta 55281, Indonesia; Corresponding author at: Department of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Jalan Denta No. 1, Sekip Utara, Yogyakarta 55281, Indonesia.Vaccines manufacture and enhancement for preventing infection and promoting quality of life are of great concern worldwide. For vaccine enhancement, to date, only limited adjuvants have been approved globally. One of them is alum, which presents several side effects and limitations. Related to vaccine administration, mucosal vaccination is a promising method since it can induce both mucosal and systemic immunity since oral mucosa is the most exposed site of the body to various microbes, pathogens, and environmental particles. Consequently, an escalated specific local immunity is required in which stability and integrity of an encapsulated antigen is expected to result in a stable mucosal vaccine to protect the antigens from degradative chemical reactions occurring in the oral cavity and act as immunomodulator. Carbonate apatite (CHA) has been one of the most innovative materials as a newly developed vaccine adjuvant since it can adequately enhance drug and protein stability and delivery in various disease therapies. However, CHA fabrication that meets the parameters for adjuvants and immunomodulators remains challenging. In the form of nanoparticles, CHA is reported to enable targeted delivery of dendritic cells (DC), enhance uptakes, cross presentation, and biodistribution, as well as immune responses. Therefore, the development of nano-CHA-encapsulated vaccine antigens is required to enhance oral mucosal vaccinations and their effectiveness to prevent diseases. This study focuses on factors and strategies that affect the designing, fabrication, and testing of CHA nanoparticles for oral mucosal vaccines, especially in the aspect of physicochemical, immunological, cellular, surface chemistry, and biofunctionalization of the nanoparticle.http://www.sciencedirect.com/science/article/pii/S2352952023000282Carbonate apatite (CHA)NanoparticlesAdjuvantOral mucosalImmunomodulatorVaccine |
spellingShingle | Andari Sarasati Hevi Wihadmadyatami Ika Dewi Ana Carbonate apatite nanoparticles: A novel nano-adjuvant for oral mucosal vaccines and immunomodulator OpenNano Carbonate apatite (CHA) Nanoparticles Adjuvant Oral mucosal Immunomodulator Vaccine |
title | Carbonate apatite nanoparticles: A novel nano-adjuvant for oral mucosal vaccines and immunomodulator |
title_full | Carbonate apatite nanoparticles: A novel nano-adjuvant for oral mucosal vaccines and immunomodulator |
title_fullStr | Carbonate apatite nanoparticles: A novel nano-adjuvant for oral mucosal vaccines and immunomodulator |
title_full_unstemmed | Carbonate apatite nanoparticles: A novel nano-adjuvant for oral mucosal vaccines and immunomodulator |
title_short | Carbonate apatite nanoparticles: A novel nano-adjuvant for oral mucosal vaccines and immunomodulator |
title_sort | carbonate apatite nanoparticles a novel nano adjuvant for oral mucosal vaccines and immunomodulator |
topic | Carbonate apatite (CHA) Nanoparticles Adjuvant Oral mucosal Immunomodulator Vaccine |
url | http://www.sciencedirect.com/science/article/pii/S2352952023000282 |
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