Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction
The cause of the cystic dilatation of the cord found in syringomyelia has been a source of conjecture for a considerable time. Recent studies have shown that there is a reduction in craniospinal compliance in both childhood hydrocephalus and multiple sclerosis which leads to venous outflow dilatatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/20/6646 |
| _version_ | 1797573468588343296 |
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| author | Grant Alexander Bateman Alexander Robert Bateman |
| author_facet | Grant Alexander Bateman Alexander Robert Bateman |
| author_sort | Grant Alexander Bateman |
| collection | DOAJ |
| description | The cause of the cystic dilatation of the cord found in syringomyelia has been a source of conjecture for a considerable time. Recent studies have shown that there is a reduction in craniospinal compliance in both childhood hydrocephalus and multiple sclerosis which leads to venous outflow dilatation. Both diseases are associated with glymphatic outflow obstruction. Venous dilatation will narrow the perivenous glymphatic outflow pathway and lead to an increase in glymphatic outflow resistance. Syringomyelia has been shown to be associated with reduced spinal canal compliance. This paper discusses the possibility that venous dilatation and obstructed glymphatic outflow within the cord may be behind the cystic dilatation found within syringomyelia. |
| first_indexed | 2024-03-10T21:10:00Z |
| format | Article |
| id | doaj.art-8c1a3141107748c59902410219fd8f5e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T21:10:00Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8c1a3141107748c59902410219fd8f5e2023-11-19T16:53:59ZengMDPI AGJournal of Clinical Medicine2077-03832023-10-011220664610.3390/jcm12206646Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid ObstructionGrant Alexander Bateman0Alexander Robert Bateman1Department of Medical Imaging, John Hunter Hospital, Newcastle, NSW 2305, AustraliaSchool of Mechanical Engineering, University of New South Wales, Sydney, NSW 2502, AustraliaThe cause of the cystic dilatation of the cord found in syringomyelia has been a source of conjecture for a considerable time. Recent studies have shown that there is a reduction in craniospinal compliance in both childhood hydrocephalus and multiple sclerosis which leads to venous outflow dilatation. Both diseases are associated with glymphatic outflow obstruction. Venous dilatation will narrow the perivenous glymphatic outflow pathway and lead to an increase in glymphatic outflow resistance. Syringomyelia has been shown to be associated with reduced spinal canal compliance. This paper discusses the possibility that venous dilatation and obstructed glymphatic outflow within the cord may be behind the cystic dilatation found within syringomyelia.https://www.mdpi.com/2077-0383/12/20/6646syringomyeliacomplianceglymphatic drainagevenous dilatationimpedance pump |
| spellingShingle | Grant Alexander Bateman Alexander Robert Bateman Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction Journal of Clinical Medicine syringomyelia compliance glymphatic drainage venous dilatation impedance pump |
| title | Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction |
| title_full | Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction |
| title_fullStr | Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction |
| title_full_unstemmed | Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction |
| title_short | Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction |
| title_sort | syringomyelia is associated with a reduction in spinal canal compliance venous outflow dilatation and glymphatic fluid obstruction |
| topic | syringomyelia compliance glymphatic drainage venous dilatation impedance pump |
| url | https://www.mdpi.com/2077-0383/12/20/6646 |
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