Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis
Th17 cells play a key role in immunity against Mycobacterium tuberculosis (MTB), and this study aimed to explore the association of Th17 pathway gene polymorphisms with pulmonary tuberculosis (PTB) susceptibility in a Chinese population. A total of 10 single nucleotide polymorphisms in Th17 pathway...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.994247/full |
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| author | Hong-Miao Li Hong-Miao Li Li-Jun Wang Qian Huang Hai-Feng Pan Tian-Ping Zhang |
| author_facet | Hong-Miao Li Hong-Miao Li Li-Jun Wang Qian Huang Hai-Feng Pan Tian-Ping Zhang |
| author_sort | Hong-Miao Li |
| collection | DOAJ |
| description | Th17 cells play a key role in immunity against Mycobacterium tuberculosis (MTB), and this study aimed to explore the association of Th17 pathway gene polymorphisms with pulmonary tuberculosis (PTB) susceptibility in a Chinese population. A total of 10 single nucleotide polymorphisms in Th17 pathway genes (IL-17A gene rs2275913, rs3748067, rs8193036, rs3819024, IL-17F gene rs7741835, rs763780, IL-21 gene rs907715, rs2055979, IL-23R gene rs11805303, and rs7518660) were genotyped in 456 PTB patients and 466 controls using SNPscan technique. The IL-23R rs11805303 CC genotype, C allele frequencies were significantly lower in PTB patients than in controls, and the rs11805303 variant was significantly associated with the reduced risk of PTB in a recessive model. There were no significant associations between IL-17A, IL-17F, and IL-21 gene variations and PTB risk. In IL-17A gene, rs2275913, rs3748067, and rs3819024 variants were associated with drug resistance in PTB patients. In IL-17F gene, rs7741835 variant affected drug resistance, and rs763780 variant was associated with hypoproteinemia in PTB patients. In addition, the lower frequencies of the TT genotype, T allele of rs2055979 were found in PTB patients with drug-induced liver injury. Haplotype analysis showed that IL-23R CG haplotype frequency was significantly lower in PTB patients than in controls, while the TG haplotype frequency was higher. In conclusion, IL-23R rs11805303 polymorphism may contribute to the genetic underpinnings of PTB in the Chinese population, and the IL-17A, IL-17F, and IL-21 genetic variations are associated with several clinical manifestations of PTB patients. |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T09:24:32Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-8c1c6987b84843f093d4e4f0dc5e10652022-12-22T02:52:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.994247994247Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosisHong-Miao Li0Hong-Miao Li1Li-Jun Wang2Qian Huang3Hai-Feng Pan4Tian-Ping Zhang5Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Public Health, Medical Department, Qinghai University, Xining, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, ChinaTh17 cells play a key role in immunity against Mycobacterium tuberculosis (MTB), and this study aimed to explore the association of Th17 pathway gene polymorphisms with pulmonary tuberculosis (PTB) susceptibility in a Chinese population. A total of 10 single nucleotide polymorphisms in Th17 pathway genes (IL-17A gene rs2275913, rs3748067, rs8193036, rs3819024, IL-17F gene rs7741835, rs763780, IL-21 gene rs907715, rs2055979, IL-23R gene rs11805303, and rs7518660) were genotyped in 456 PTB patients and 466 controls using SNPscan technique. The IL-23R rs11805303 CC genotype, C allele frequencies were significantly lower in PTB patients than in controls, and the rs11805303 variant was significantly associated with the reduced risk of PTB in a recessive model. There were no significant associations between IL-17A, IL-17F, and IL-21 gene variations and PTB risk. In IL-17A gene, rs2275913, rs3748067, and rs3819024 variants were associated with drug resistance in PTB patients. In IL-17F gene, rs7741835 variant affected drug resistance, and rs763780 variant was associated with hypoproteinemia in PTB patients. In addition, the lower frequencies of the TT genotype, T allele of rs2055979 were found in PTB patients with drug-induced liver injury. Haplotype analysis showed that IL-23R CG haplotype frequency was significantly lower in PTB patients than in controls, while the TG haplotype frequency was higher. In conclusion, IL-23R rs11805303 polymorphism may contribute to the genetic underpinnings of PTB in the Chinese population, and the IL-17A, IL-17F, and IL-21 genetic variations are associated with several clinical manifestations of PTB patients.https://www.frontiersin.org/articles/10.3389/fimmu.2022.994247/fullpulmonary tuberculosisTh17 pathway genesIL-17AIL-17FIL-21IL-23R |
| spellingShingle | Hong-Miao Li Hong-Miao Li Li-Jun Wang Qian Huang Hai-Feng Pan Tian-Ping Zhang Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis Frontiers in Immunology pulmonary tuberculosis Th17 pathway genes IL-17A IL-17F IL-21 IL-23R |
| title | Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis |
| title_full | Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis |
| title_fullStr | Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis |
| title_full_unstemmed | Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis |
| title_short | Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis |
| title_sort | exploring the association between th17 pathway gene polymorphisms and pulmonary tuberculosis |
| topic | pulmonary tuberculosis Th17 pathway genes IL-17A IL-17F IL-21 IL-23R |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.994247/full |
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