Optimization of therapy for hepatobiliary disorders in psoriatic patients
Aim. To optimize management tactics in patients with diseases of the liver and gallbladder in the presence of progressive psoriasis. Subjects and methods. The investigation enrolled 78 patients with nonalcoholic fatty liver disease (NAFLD) and different forms of gallbladder abnormality in the presen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2017-12-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/32370 |
| _version_ | 1818610769980293120 |
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| author | I V Kozlova Yu N Myalina L P Lipina A L Bakulev |
| author_facet | I V Kozlova Yu N Myalina L P Lipina A L Bakulev |
| author_sort | I V Kozlova |
| collection | DOAJ |
| description | Aim. To optimize management tactics in patients with diseases of the liver and gallbladder in the presence of progressive psoriasis. Subjects and methods. The investigation enrolled 78 patients with nonalcoholic fatty liver disease (NAFLD) and different forms of gallbladder abnormality in the presence of progressive moderate and severe psoriasis. The patients were randomly divided into 2 groups: 1) phosphogliv; 2) ursosan with the main active ingredient ursodeoxycholic acid (UDCA). A prospective follow-up study accompanied by dynamic clinical, laboratory, and instrumental monitoring was carried out for 24 weeks. Clinical, biochemical, and ultrasound studies, including liver elastography, were applied. Results. The use of UDCA (Ursosan 15 mg/kg for 24 weeks) to treat NAFLD and gallbladder abnormality in methotrexate-treated patients with progressive moderate and severe psoriasis contributed to the normalization of hepatic steatosis index, lipid composition, and lithogenic index, to the reduction of biliary sludge, and to the stabilization of liver fibrosis. Improvement in the functional status of the liver and gallbladder has contributed to the achievement of a more complete remission of dermatosis. Conclusion. The effects of UDCA in the therapy of NAFLD and gallbladder abnormality in patients with progressive psoriasis were greater than those of phosphogliv. |
| first_indexed | 2024-12-16T15:19:42Z |
| format | Article |
| id | doaj.art-8c1e49dbc83b4f8c935cc63df8b87c56 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-16T15:19:42Z |
| publishDate | 2017-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-8c1e49dbc83b4f8c935cc63df8b87c562022-12-21T22:26:40Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422017-12-018912-220421010.17116/terarkh20178912204-21029370Optimization of therapy for hepatobiliary disorders in psoriatic patientsI V KozlovaYu N MyalinaL P LipinaA L BakulevAim. To optimize management tactics in patients with diseases of the liver and gallbladder in the presence of progressive psoriasis. Subjects and methods. The investigation enrolled 78 patients with nonalcoholic fatty liver disease (NAFLD) and different forms of gallbladder abnormality in the presence of progressive moderate and severe psoriasis. The patients were randomly divided into 2 groups: 1) phosphogliv; 2) ursosan with the main active ingredient ursodeoxycholic acid (UDCA). A prospective follow-up study accompanied by dynamic clinical, laboratory, and instrumental monitoring was carried out for 24 weeks. Clinical, biochemical, and ultrasound studies, including liver elastography, were applied. Results. The use of UDCA (Ursosan 15 mg/kg for 24 weeks) to treat NAFLD and gallbladder abnormality in methotrexate-treated patients with progressive moderate and severe psoriasis contributed to the normalization of hepatic steatosis index, lipid composition, and lithogenic index, to the reduction of biliary sludge, and to the stabilization of liver fibrosis. Improvement in the functional status of the liver and gallbladder has contributed to the achievement of a more complete remission of dermatosis. Conclusion. The effects of UDCA in the therapy of NAFLD and gallbladder abnormality in patients with progressive psoriasis were greater than those of phosphogliv.https://ter-arkhiv.ru/0040-3660/article/view/32370psoriasisnon-alcoholic fatty liver diseasehepatic steatosis indexlithogenic indexursodeoxycholic acid (ursosan) |
| spellingShingle | I V Kozlova Yu N Myalina L P Lipina A L Bakulev Optimization of therapy for hepatobiliary disorders in psoriatic patients Терапевтический архив psoriasis non-alcoholic fatty liver disease hepatic steatosis index lithogenic index ursodeoxycholic acid (ursosan) |
| title | Optimization of therapy for hepatobiliary disorders in psoriatic patients |
| title_full | Optimization of therapy for hepatobiliary disorders in psoriatic patients |
| title_fullStr | Optimization of therapy for hepatobiliary disorders in psoriatic patients |
| title_full_unstemmed | Optimization of therapy for hepatobiliary disorders in psoriatic patients |
| title_short | Optimization of therapy for hepatobiliary disorders in psoriatic patients |
| title_sort | optimization of therapy for hepatobiliary disorders in psoriatic patients |
| topic | psoriasis non-alcoholic fatty liver disease hepatic steatosis index lithogenic index ursodeoxycholic acid (ursosan) |
| url | https://ter-arkhiv.ru/0040-3660/article/view/32370 |
| work_keys_str_mv | AT ivkozlova optimizationoftherapyforhepatobiliarydisordersinpsoriaticpatients AT yunmyalina optimizationoftherapyforhepatobiliarydisordersinpsoriaticpatients AT lplipina optimizationoftherapyforhepatobiliarydisordersinpsoriaticpatients AT albakulev optimizationoftherapyforhepatobiliarydisordersinpsoriaticpatients |