Asymmetric right/left encoding of emotions in the human subthalamic nucleus
Emotional processing is lateralized to the non-dominant brain hemisphere. However, there is no clear spatial model for lateralization of emotional domains in the basal ganglia. The subthalamic nucleus (STN), an input structure in the basal ganglia network, plays a major role in the pathophysiology o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-10-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2013.00069/full |
| _version_ | 1818476315569815552 |
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| author | Renana eEitan Reuben Ruby Shamir Reuben Ruby Shamir Reuben Ruby Shamir Eduard eLinetsky Ovadya eRosenbluh Shay eMoshel Shay eMoshel Shay eMoshel Shay eMoshel Tamir eBen-Hur Hagai eBergman Hagai eBergman Zvi eIsrael |
| author_facet | Renana eEitan Reuben Ruby Shamir Reuben Ruby Shamir Reuben Ruby Shamir Eduard eLinetsky Ovadya eRosenbluh Shay eMoshel Shay eMoshel Shay eMoshel Shay eMoshel Tamir eBen-Hur Hagai eBergman Hagai eBergman Zvi eIsrael |
| author_sort | Renana eEitan |
| collection | DOAJ |
| description | Emotional processing is lateralized to the non-dominant brain hemisphere. However, there is no clear spatial model for lateralization of emotional domains in the basal ganglia. The subthalamic nucleus (STN), an input structure in the basal ganglia network, plays a major role in the pathophysiology of Parkinson’s disease (PD). This role is probably not limited only to the motor deficits of PD, but may also span the emotional and cognitive deficits commonly observed in PD patients. Beta oscillations (12-30Hz), the electrophysiological signature of PD, are restricted to the dorsolateral part of the STN that corresponds to the anatomically defined sensorimotor STN. The more medial, more anterior and more ventral parts of the STN are thought to correspond to the anatomically defined limbic and associative territories of the STN. Surprisingly, little is known about the electrophysiological properties of the non-motor domains of the STN, nor about electrophysiological differences between right and left STNs.In this study, microelectrodes were utilized to record the STN spontaneous spiking activity and responses to vocal non-verbal emotional stimuli during deep brain stimulation (DBS) surgeries in human PD patients. The oscillation properties of the STN neurons were used to map the dorsal oscillatory and the ventral non-oscillatory regions of the STN. Emotive auditory stimulation evoked activity in the ventral non-oscillatory region of the right STN. These responses were not observed in the left ventral STN or in the dorsal regions of either the right or left STN. Therefore, our results suggest that the ventral non-oscillatory regions are asymmetrically associated with non-motor functions, with the right ventral STN associated with emotional processing. These results suggest that DBS of the right ventral STN may be associated with beneficial or adverse emotional effects observed in PD patients and may relieve mental symptoms in other neurological and psychiatric diseases. |
| first_indexed | 2024-12-10T09:23:57Z |
| format | Article |
| id | doaj.art-8c1f353113bf4aac9e6703569fe8c9bd |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-10T09:23:57Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-8c1f353113bf4aac9e6703569fe8c9bd2022-12-22T01:54:35ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372013-10-01710.3389/fnsys.2013.0006962791Asymmetric right/left encoding of emotions in the human subthalamic nucleusRenana eEitan0Reuben Ruby Shamir1Reuben Ruby Shamir2Reuben Ruby Shamir3Eduard eLinetsky4Ovadya eRosenbluh5Shay eMoshel6Shay eMoshel7Shay eMoshel8Shay eMoshel9Tamir eBen-Hur10Hagai eBergman11Hagai eBergman12Zvi eIsrael13Hadassah-Hebrew University Medical CenterThe Hebrew UniversityThe Hebrew UniversityHadassah-Hebrew University Medical CenterHadassah-Hebrew University Medical CenterHadassah-Hebrew University Medical CenterThe Hebrew UniversityThe Hebrew UniversityHadassah-Hebrew University Medical CenterThe Jerusalem mental health center, Kfar-Shaul EtanimHadassah-Hebrew University Medical CenterThe Hebrew UniversityThe Hebrew UniversityHadassah-Hebrew University Medical CenterEmotional processing is lateralized to the non-dominant brain hemisphere. However, there is no clear spatial model for lateralization of emotional domains in the basal ganglia. The subthalamic nucleus (STN), an input structure in the basal ganglia network, plays a major role in the pathophysiology of Parkinson’s disease (PD). This role is probably not limited only to the motor deficits of PD, but may also span the emotional and cognitive deficits commonly observed in PD patients. Beta oscillations (12-30Hz), the electrophysiological signature of PD, are restricted to the dorsolateral part of the STN that corresponds to the anatomically defined sensorimotor STN. The more medial, more anterior and more ventral parts of the STN are thought to correspond to the anatomically defined limbic and associative territories of the STN. Surprisingly, little is known about the electrophysiological properties of the non-motor domains of the STN, nor about electrophysiological differences between right and left STNs.In this study, microelectrodes were utilized to record the STN spontaneous spiking activity and responses to vocal non-verbal emotional stimuli during deep brain stimulation (DBS) surgeries in human PD patients. The oscillation properties of the STN neurons were used to map the dorsal oscillatory and the ventral non-oscillatory regions of the STN. Emotive auditory stimulation evoked activity in the ventral non-oscillatory region of the right STN. These responses were not observed in the left ventral STN or in the dorsal regions of either the right or left STN. Therefore, our results suggest that the ventral non-oscillatory regions are asymmetrically associated with non-motor functions, with the right ventral STN associated with emotional processing. These results suggest that DBS of the right ventral STN may be associated with beneficial or adverse emotional effects observed in PD patients and may relieve mental symptoms in other neurological and psychiatric diseases.http://journal.frontiersin.org/Journal/10.3389/fnsys.2013.00069/fullEmotionsParkinson DiseaseSubthalamic NucleusasymmetryemotionParkinson's disease |
| spellingShingle | Renana eEitan Reuben Ruby Shamir Reuben Ruby Shamir Reuben Ruby Shamir Eduard eLinetsky Ovadya eRosenbluh Shay eMoshel Shay eMoshel Shay eMoshel Shay eMoshel Tamir eBen-Hur Hagai eBergman Hagai eBergman Zvi eIsrael Asymmetric right/left encoding of emotions in the human subthalamic nucleus Frontiers in Systems Neuroscience Emotions Parkinson Disease Subthalamic Nucleus asymmetry emotion Parkinson's disease |
| title | Asymmetric right/left encoding of emotions in the human subthalamic nucleus |
| title_full | Asymmetric right/left encoding of emotions in the human subthalamic nucleus |
| title_fullStr | Asymmetric right/left encoding of emotions in the human subthalamic nucleus |
| title_full_unstemmed | Asymmetric right/left encoding of emotions in the human subthalamic nucleus |
| title_short | Asymmetric right/left encoding of emotions in the human subthalamic nucleus |
| title_sort | asymmetric right left encoding of emotions in the human subthalamic nucleus |
| topic | Emotions Parkinson Disease Subthalamic Nucleus asymmetry emotion Parkinson's disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2013.00069/full |
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