Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE

Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE

Factor I (FI) is an essential regulator of the complement system. Together with co-factors, FI degrades C3b, which inhibits further complement activation. Genetic mutations in FI are associated with pathological conditions like age-related macular degeneration and atypical hemolytic uremic syndome....

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Bibliographic Details
Main Authors: Alexandra Gerogianni, Laura M. Baas, Dick J. Sjöström, Nicole C. A. J. van de Kar, Marit Pullen, Siem J. van de Peppel, Per H. Nilsson, Lambertus P. van den Heuvel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
factor I
co-factor activity
functional assay
complement regulation
factor H
complement receptor I
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279612/full

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