Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant <i>Musca domestica</i> (Diptera: Muscidae)
<i>Musca domestica</i> L., a pest of animals and humans, has developed resistance to alpha-cypermethrin, a pyrethroid insecticide commonly used to control medically important pests in many countries, including Saudi Arabia. We investigated the mechanism underlying the development of alph...
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MDPI AG
2023-07-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/7/1021 |
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| author | Abdulwahab M. Hafez Naeem Abbas |
| author_facet | Abdulwahab M. Hafez Naeem Abbas |
| author_sort | Abdulwahab M. Hafez |
| collection | DOAJ |
| description | <i>Musca domestica</i> L., a pest of animals and humans, has developed resistance to alpha-cypermethrin, a pyrethroid insecticide commonly used to control medically important pests in many countries, including Saudi Arabia. We investigated the mechanism underlying the development of alpha-cypermethrin resistance and life history characteristics of alpha-cypermethrin–susceptible (Alpha-SS) and alpha-cypermethrin-resistant (Alpha-RS) <i>M. domestica</i> using the age-stage, two-sex life table theory, which is crucial for developing a future rational management strategy and minimizing the negative effects of alpha-cypermethrin on the environment. Our results showed that Alpha-RS <i>M. domestica</i> had a 405.93-fold increase in resistance to alpha-cypermethrin relative to Alpha-SS <i>M. domestica</i>. This increase in the resistance toward insecticide was attributed to metabolic enzymes, such as glutathione S-transferases, specific esterases, and cytochrome P450 monooxygenases. Furthermore, Alpha-RS <i>M. domestica</i> exhibited lower relative fitness (0.50), longevity, survival rate, life expectancy, reproductive values, intrinsic rate of increase, net reproductive rate, fecundity, maternity, and finite rate of increase, along with shorter larval, female preadult, and adult durations than Alpha-SS <i>M. domestica</i>, indicating fitness costs associated with most parameters. However, no significant differences were found between the strains in the following parameters: egg, pupa, and male preadult durations; adult preoviposition, total preoviposition, and oviposition periods; female ratio; and total generation time. Additionally, Alpha-RS <i>M. domestica</i> had a markedly lower intrinsic rate of increase, net reproductive rate, and finite rate of increase than Alpha-SS <i>M. domestica</i>. The results of this study suggest that alpha-cypermethrin resistance may lead to dominant fitness costs in <i>M. domestica</i>. Overall, these findings will aid in the development of rational control strategies for <i>M. domestica</i> as well as help to reduce pesticide pollution. |
| first_indexed | 2024-03-11T01:17:44Z |
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| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T01:17:44Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-8c20a04638de421aa0d458897140599d2023-11-18T18:24:28ZengMDPI AGBiology2079-77372023-07-01127102110.3390/biology12071021Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant <i>Musca domestica</i> (Diptera: Muscidae)Abdulwahab M. Hafez0Naeem Abbas1Pesticides and Environmental Toxicology Laboratory, Department of Plant Protection, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi ArabiaPesticides and Environmental Toxicology Laboratory, Department of Plant Protection, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia<i>Musca domestica</i> L., a pest of animals and humans, has developed resistance to alpha-cypermethrin, a pyrethroid insecticide commonly used to control medically important pests in many countries, including Saudi Arabia. We investigated the mechanism underlying the development of alpha-cypermethrin resistance and life history characteristics of alpha-cypermethrin–susceptible (Alpha-SS) and alpha-cypermethrin-resistant (Alpha-RS) <i>M. domestica</i> using the age-stage, two-sex life table theory, which is crucial for developing a future rational management strategy and minimizing the negative effects of alpha-cypermethrin on the environment. Our results showed that Alpha-RS <i>M. domestica</i> had a 405.93-fold increase in resistance to alpha-cypermethrin relative to Alpha-SS <i>M. domestica</i>. This increase in the resistance toward insecticide was attributed to metabolic enzymes, such as glutathione S-transferases, specific esterases, and cytochrome P450 monooxygenases. Furthermore, Alpha-RS <i>M. domestica</i> exhibited lower relative fitness (0.50), longevity, survival rate, life expectancy, reproductive values, intrinsic rate of increase, net reproductive rate, fecundity, maternity, and finite rate of increase, along with shorter larval, female preadult, and adult durations than Alpha-SS <i>M. domestica</i>, indicating fitness costs associated with most parameters. However, no significant differences were found between the strains in the following parameters: egg, pupa, and male preadult durations; adult preoviposition, total preoviposition, and oviposition periods; female ratio; and total generation time. Additionally, Alpha-RS <i>M. domestica</i> had a markedly lower intrinsic rate of increase, net reproductive rate, and finite rate of increase than Alpha-SS <i>M. domestica</i>. The results of this study suggest that alpha-cypermethrin resistance may lead to dominant fitness costs in <i>M. domestica</i>. Overall, these findings will aid in the development of rational control strategies for <i>M. domestica</i> as well as help to reduce pesticide pollution.https://www.mdpi.com/2079-7737/12/7/1021house flypyrethroid resistancedetoxification enzymesage-stage life tabledemographic traits |
| spellingShingle | Abdulwahab M. Hafez Naeem Abbas Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant <i>Musca domestica</i> (Diptera: Muscidae) Biology house fly pyrethroid resistance detoxification enzymes age-stage life table demographic traits |
| title | Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant <i>Musca domestica</i> (Diptera: Muscidae) |
| title_full | Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant <i>Musca domestica</i> (Diptera: Muscidae) |
| title_fullStr | Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant <i>Musca domestica</i> (Diptera: Muscidae) |
| title_full_unstemmed | Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant <i>Musca domestica</i> (Diptera: Muscidae) |
| title_short | Biological Fitness Cost, Demographic Growth Characteristics, and Resistance Mechanism in Alpha-Cypermethrin-Resistant <i>Musca domestica</i> (Diptera: Muscidae) |
| title_sort | biological fitness cost demographic growth characteristics and resistance mechanism in alpha cypermethrin resistant i musca domestica i diptera muscidae |
| topic | house fly pyrethroid resistance detoxification enzymes age-stage life table demographic traits |
| url | https://www.mdpi.com/2079-7737/12/7/1021 |
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