Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling

Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling

IntroductionCardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is multi-factorial,...

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Main Authors: B. Reilly-O’Donnell, E. Ferraro, R. Tikhomirov, R. Nunez-Toldra, A. Shchendrygina, L. Patel, Y. Wu, A. L. Mitchell, A. Endo, L. Adorini, R. A. Chowdhury, P. K. Srivastava, F. S. Ng, C. Terracciano, C. Williamson, J. Gorelik
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiac fibrosis
antifibrotic
TGR5
ursodeoxycholic acid
dilated cardiomyopathy
Interleukin-11
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2024.1430772/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2024.1430772/full

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